Jiangnan University

Integrated Transporter Engineering and Semi-Rational Enzyme Design in Corynebacterium glutamicum for High-Level Natural Blue Pigment Indigoidine Production

Abstract Indigoidine is a sustainable natural blue pigment with broad industrial prospects, while its microbial production is hampered by growth inhibition of the producing strain, enzyme-host incompatibility, and insufficient industrial-scale titer. In this study, de novo biosyn...

Comparing Airbnb hosts’ and guests’ attitudes toward smart technology to support authenticity experiences

Purpose This study aims to examine how smart technology in peer-to-peer (P2P) accommodation may support, disrupt or reconfigure authenticity-related experiences. Focusing on Airbnb stays as a tension-laden hospitality context, it investigates how hosts’ intentions and guest-side...

Spirocyclic Bio-Based Epoxy Resins from Lignin-Derived Guaiacol: Molecular Design for Enhanced Thermal, Mechanical, and Hygrothermal Stability

Abstract Growing global demand for sustainable materials has driven the development of high-performance biobased epoxy resins. However, conventional strategies are plagued by reliance on fossil resources and subpar performance across key metrics (e.g., glass transition temperatur...

A Sequence-to-Scaffold Platform Enables Programmable Carrier-Supported Biocatalysis for Nucleoside Analog Synthesis

Abstract Industrial biocatalysis increasingly requires strategies that convert enzyme discovery into robust catalyst systems for process implementation. Here, we report Spatially Programmable Assembly of Computationally Mined Enzymes (SPACE), a sequence-to-scaffold workflow coupl...

Intramolecular Dearomative [2 + 2] Cycloadditions of (Hetero)arenes Utilizing an Energy-Transfer Organic Photocatalyst

Abstract Expanding the application scope of organic photoredox catalysts is of considerable importance in photocatalysis. Herein, we report an energy transfer (EnT)-mediated intramolecular dearomative [2+2] cycloaddition of N-substituted-N-(2-arylallyl)-2-naphthamides, N-acryloyl...

Hermes \({}^{+}\) : Adaptive Memory-Efficient Pipeline Inference for Large Models on Edge Devices

The application of Transformer-based large models has achieved significant success in recent years. However, the exponential growth in the parameters of large models introduces formidable memory challenges for edge deployment. Prior works to address this challenge mainly focus on...

Pharmacological Activities, Biosynthetic Strategies, and Future Prospects: A Comprehensive Review of Baicalein

Abstract Baicalein, a 4′-deoxyflavone from Scutellaria baicalensis Georgi, possesses diverse pharmacological activities including antimicrobial, antifibrotic, antiviral, antitumor, and antioxidant effects. Its effective antioxidant and anti-inflammatory properties position it as...

Adaptive Sage-Husa Kalman filter for 3D indoor positioning with multi-sensor fusion

In complex indoor environments, standalone bluetooth positioning often suffers from significant performance degradation due to non-line-of-sight (NLOS) propagation and environmental disturbances. Meanwhile, position estimates derived from inertial measurement unit (IMU) data are...

Novel pretreatments for vacuum freeze-drying: Effects on the drying process and quality of dried mango cubes

Vacuum freeze-drying is one of the primary technologies for producing high-quality fruit and vegetable products. As a critical step, pretreatment significantly affects both the drying process and product quality. This study employed ultrasound (US), electric field (EF), osmotic d...

LncFENIX restricts influenza A virus replication by impairing PDIA3-mediated oxidative folding of hemagglutinin

Influenza A virus (IAV) relies on host endoplasmic reticulum (ER) homeostasis machinery to support the oxidative folding and maturation of viral glycoproteins. Although long non-coding RNAs (lncRNAs) are increasingly recognized as critical regulators of host-virus interactions, w...

Detection of Multi-Serotype Salmonella Based on Conserved Antigen Molecular Recognition

Abstract Salmonella is a common foodborne pathogen. Antibodies against Salmonella are typically generated using inactivated whole bacterial cells as immunogens; however, the lack of studies on the recognition mechanism has limited antibody development. In this work, immunoinforma...

An improved Gated Recurrent Unit model with hybrid network architecture for carbon emission forecasting in Zhejiang Province

To address the nonlinearity and non-stationarity of carbon emission time series and remedy the defects of existing hybrid models in parameter configuration and module coordination, this study develops a Bayesian Optimization-Variational Mode Decomposition-Convolutional Neural Net...

Age-dependent patterns of gut Bifidobacterium microbiome in child cohort across a multi-ethnic population, Western China

The gut microbiome evolves dynamically throughout human development, influencing health at different life stages. However, current studies have primarily focused on infant and adult cohorts, leaving biomarkers associated with children in transitional developmental stages insuffic...

Food-Derived Antihypertensive Peptides: A Comprehensive Review of Preparation Strategies, Multitarget Mechanisms, and Machine Learning Advancements

Abstract Hypertension remains a major risk factor for cardiovascular disease worldwide and a formidable global health challenge. The clinical triumph of peptide-based drugs underscores the immense potential of bioactive peptides in hypertension management. Recently, food-derived...

Variational autoencoder-based robust learning control for nonlinear systems with piecewise disturbances

This paper proposes an adaptive reinforcement learning framework based on a Variational Autoencoder (VAE) for robust control of nonlinear systems subject to piecewise disturbances. The framework addresses incomplete state information in partially observable environments by augmen...

Beyond the 15-Minute Circle: From Nominal Coverage to Effective and Equitable Access to Community Health Service Centers for Older Adults in Central Nanjing

Population aging has increased demand for walkable community healthcare for older adults. Using the six central districts of Nanjing as a case study, this study examines whether nominal 15 min access to community health service centers (CHSCs) translates into effective and equita...

Plasma–Microreactor Integration for Green and Continuous Synthesis of Pt/GO Electrocatalysts

Abstract The green and continuous preparation of supported noble metal catalysts is crucial for both fundamental research and industrial applications but remains highly challenging. Herein, a continuous microflow strategy that integrates dielectric barrier discharge (DBD) plasma...

A frequency-enhanced interpretable patch decomposition network for seakeeping prediction under irregular-wave conditions

To address the challenge that the nonlinear and locally time-varying characteristics of ship motion responses under irregular-wave conditions make it difficult for existing forecasting models to sufficiently characterize key frequency components and historical segment contributio...

One‐Step Pyrolysis and ZnO Nanostructure Functionalization of Flexible Textiles for Multimodal Sensing of Pressure, Temperature and Sunlight

ABSTRACT Wearables with multimodal sensing capabilities can capture rich, synchronized physiological and environmental data, but remain difficult to fabricate and continue to face challenges with signal crosstalk. Here, we show how laser irradiation of textiles treated with zinc...

Engineering an F-Amine Dehydrogenase for Efficient and Sustainable Biocatalytic Synthesis of a Chiral PDE10 Inhibitor Precursor

Abstract (R)–4-(1H-indol-3-yl)butan-2-amine ((R)-4IBA), encompassing a nitrogen heterocycle and a chiral primary amino group, is a highly appealing precursor in the pharmaceutical domain. The direct amination of the readily available prochiral ketone 4-(1H-indol-3-yl)butan-2-one...