Jagiellonian University

Sea‐level highstand recorded in the Last Interglacial shallow marine deposits from the Tangier region, Morocco

ABSTRACT The Moroccan coast provides valuable insight into how large‐scale climate and sea‐level variations have manifested themselves at the regional level. In this paper, we present new findings from shallow marine deposits in the Achakkar Basin near Tangier, Morocco. Data from...

A global analysis of population differentiation at the major histocompatibility complex genes across tetrapods

Major histocompatibility complex (MHC) genes are central to pathogen recognition by the adaptive immune system of jawed vertebrates, with MHC classes I and II (henceforth referred to as MHC-I and MHC-II, respectively) primarily mediating responses to intracellular and extracellul...

Functionalization of Metal-Enriched Pleurotus Biomass with γ-Poly-Glutamic Acid for Cytoprotective and Antimicrobial Wound Care

Objectives: Chronic wound dressings require active components that support moisture management, biocompatibility, and local bioburden control. Therefore, in this study, freeze-dried biomass of Pleurotus ostreatus (Po) and Pleurotus djamor (Pdj) was cultivated in vitro under miner...

A Unified Operator Resolution of Quadratic Bond Orders

Abstract Quadratic bond-order indices provide compact measures of chemical covalency, but their scalar form conceals the orbital channels contributing to a bond. We present a common operator framework for closed-shell, open-shell, and correlated one-particle densities in a fixed...

Cultivar-Dependent Phytochemical Composition and Cosmetic Potential of Grapevine Callus Cultures

Plant callus cultures are increasingly explored as a source of skin-care ingredients because they enable the production of biomass rich in bioactive metabolites under controlled and reproducible conditions. Callus cultures offer a promising platform for the controlled production...

Public health workforce reform in Abu Dhabi: a pathway to evidence-based policy and global standards alignment

Reforming the public health workforce in Abu Dhabi and across the United Arab Emirates (UAE) became increasingly urgent during and after the COVID-19 pandemic, alongside wider pressures from evolving public health challenges and health-system transformation. A mixed-methods study...

Optimal Depolarization Sequence for CRT Patients

Abstract Background Electrical ventricular dyssynchrony is a hallmark of intraventricular conduction disease in heart failure with reduced ejection fraction. Although cardiac resynchronization therapy (CRT) is effective, a proportion of patients with ECG evidenced electrical dyss...

Choosing Between Anti-TROP2 ADCs in Advanced Breast Cancer Without Head-to-Head Evidence: A Practical Evidence-Informed Decision Framework Endorsed by the Polish Society of Clinical Oncology

Background/Objectives: Antibody–drug conjugates (ADCs) targeting trophoblast cell-surface antigen 2 (TROP2), including sacituzumab govitecan (SG) and datopotamab deruxtecan (Dato-DXd), have expanded treatment options for patients with advanced breast cancer. Although both agents...

Biotic and abiotic drivers of ecosystem functioning differ between a temperate and a tropical region

Any single ecosystem will provide many ecosystem functions. Yet, we lack large‐scale, systematic studies of how abiotic factors can directly or indirectly – via effects on biodiversity – drive ecosystem functioning. In this study, we assessed the impact of climate, landscape and...

Shared and vaccine-specific factors associated with COVID-19 and influenza vaccination intentions among adults in Poland: a COM-B-informed cross-sectional study

Introduction Vaccination intentions reflect both vaccine-specific attitudes and cognitive, social, and practical conditions. This study aimed to identify shared and vaccine-specific factors associated with COVID-19 and influenza vaccination intentions among adults in Poland using...

Constraints on new theories using Rivet: CONTUR version 3 release note

The CONTUR toolkit exploits RIVET and its library of more than a thousand energy-frontier differential cross-section measurements from the Large Hadron Collider to allow rapid limit-setting and consistency checks for new physics models. In this note we summarise the main changes...

Assessing consciousness in end-stage ALS: response to young’s commentary

We were pleased to address Dr. Michael Young’s insightful comment on our recent article, “Brain activity in an end-stage ALS patient suggests the presence of an unresponsive wakefulness syndrome”. ...

Saponins induce lipid-dependent structural heterogeneity and modulate membrane organization in phospholipid bilayers

Abstract Saponins are amphiphilic natural compounds whose membrane activity is commonly attributed to sterol complexation, whereas their effects on sterol-free membranes remain poorly understood. Here, we investigated how lipid packing governs the interaction of a Saponaria offic...

Endothelial senescence impairs efferocytosis and alters macrophage responses: insights into APP-CD74 signaling

Abstract Background Endothelial cell senescence contributes to vascular aging and chronic inflammation, yet its impact on endothelial–macrophage interactions remains poorly understood. Here, we combined functional assays, global proteomics, 3D co-culture spheroid models, and sing...

Estimating value-at-risk: LSTM vs. GARCH

Abstract Estimating value-at-risk on time series data with potentially heteroskedastic dynamics is a highly challenging task. In practical applications, one often faces limited sample sizes in combination with a high degree of non-linearity, which poses difficulties for both clas...

Timing and trajectory of acute kidney injury predict mortality in alcohol-associated hepatitis: A multinational cohort study.

BACKGROUND: Acute kidney injury (AKI) is common in alcohol-associated hepatitis (AH) and associated with poor outcomes, yet the prognostic implications of AKI timing and early renal trajectory remain unclear. METHODS: In this prospective multicenter cohort from the Global AlcHep...

Two questions of Kowalski–Słomczyńska

That the inclusion $$Q(F_3(X))\subseteq \textsf{Pa}^-_3$$ is proper and $${{\,\textrm{Mod}\,}}(\textbf{qb}_3)$$ is not generated by free p-algebras is proved, answering two open questions by Kowalski–Słomczyńska.

The Micromechanical Measurement of Photothermal Expansion †

The measurement of photothermal expansion via the deflection of a cantilevered probe has attracted attention as a tool for the investigation of condensed-phase materials. In the present work, I provide a simple theoretical analysis of signal generation by this micromechanical det...

Finite element approximation of a hemivariational inequality for steady-state heat conduction: double-limit convergence of penalization and discretization

In this paper we study the numerical approximation and convergence analysis of a steady-state heat conduction problem with mixed boundary conditions. The physical model is governed by a hemivariational inequality depending on a heat transfer parameter α > 0. We consider the finit...

Mastering a simulation-based parametric method to obtain bias-corrected point estimates and sampling variance for effect sizes

Abstract Meta-analyses require an effect-size estimate and its corresponding sampling variance from primary studies. For some effect size statistics, however, estimators of sampling variance are unavailable, requiring new derivations. Traditionally, such formulas are obtained usi...