IRCCS Ospedale Galeazzi - Sant'Ambrogio

Travel distance to tertiary healthcare reflects disease severity and medication access in Italian systemic sclerosis patients: a geographical study on adult-onset rare diseases from SPRING-SIR registry

Systemic sclerosis (SSc) is a rare, multiorgan disease in adults that requires specialized care. Commuting to tertiary medical centers poses a considerable burden and incurs significant costs, potentially affecting management choices. This study aims to describe the healthcare co...

The Role of Targeted Rehabilitation in Enhancing Recovery After Total Hip Arthroplasty with Anterior Minimally Invasive Surgery Approach: A Retrospective Pilot Study

Background: Hip osteoarthritis is a highly prevalent degenerative condition and a leading indication for total hip arthroplasty (THA). As anterior approaches have gained popularity, optimizing postoperative rehabilitation according to the muscles involved in recovery has become i...

What are the knowledge, use, and perceived benefits and limitations of artificial intelligence chatbots among Italian nursing students? A cross-sectional multicentre study

Exploring students’ knowledge, use, and perceptions of Artificial Intelligence (AI) chatbots may inform strategies in the educational context. However, limited evidence is available on Italian nursing students, leaving this field largely unexplored. A cross-sectional online surve...

FOXC1 and its lncRNA FOXCUT link DNA methylation to a chondrocyte phenotype dysfunction

Abstract Objective With current osteoarthritis (OA) therapies limited to symptom management, understanding molecular drivers of disease progression is critical. As epigenetic mechanisms increasingly appear central to OA pathogenesis, this study aimed to identify epigenetically dy...

Learning new recycling rules through virtual reality: a field study on knowledge, self-efficacy, and intentions

Although environmental concern is widespread, sustainable behaviors often break down when individuals are confronted with new or changing rules. While virtual reality (VR) has emerged as a promising tool for sustainability interventions, most supporting evidence derives from cont...

Utilization of Carbon Fiber Spinal Instrumentation in Primary Spinal Tumors: Outcome Analysis from the AO Spine Primary Tumor Research and Outcomes Network

Background The use of carbon fiber-reinforced polyetheretherketone (CFR-PEEK) instrumentation in spinal surgery has emerged as an alternative to traditional titanium-based implants in recent years. This study aims to evaluate the use and performance of carbon fiber instrumentatio...

Platform-specific learning curve and early tibial radiographic agreement of ROSA®-assisted medial unicompartmental knee arthroplasty in an experienced high-volume surgeon: a consecutive case series

Abstract Purpose To evaluate the platform-specific learning curve and early tibial radiographic agreement of imageless ROSA ® -assisted medial unicompartmental knee arthroplasty (UKA), with short-term clinical findings assessed exploratorily. Methods This retrospective consecutiv...

Operation Melilli, forensic humanitarian medico legal activities on the largest known Mediterranean disaster: the shipwreck of April 18th, 2015

On April 18th, 2015, a boat carrying about 1,000 migrants sank in the Strait of Sicily, prompting one of the most complex recovery missions ever conducted in the Mediterranean. Operation Melilli was the first time a European Government authorized the recovery of a sunken migrant...

Iron oral supplementation in anemic patients undergoing orthopedic prosthetic surgery: a randomised trial comparing short_term and prolonged administration regimen

Preoperative anaemia in patients undergoing major elective orthopaedic surgery is a relatively frequent condition and is associated with perioperative transfusions. The aim of the present study was to investigate the efficacy of liposomal iron, folic acid, and vitamins in reducin...