Istinye University

Synthesis, in silico study and cytotoxic evaluation of new benzimidazole derivatives as potential aromatase inhibitors

AIMS: ) was designed, synthesized, and evaluated as potential aromatase inhibitors with anticancer activity. MATERIALS AND METHODS: ADMET profiling were performed for the selected compounds. RESULTS: values (2.40-2.64 µM), surpassing cisplatin, while maintaining favorable selecti...

Breastfeeding Attitudes and Early Postpartum Breastfeeding Practices Among Turkish and Syrian Immigrant Mothers: A Comparative Study

Breastfeeding is a key public health practice that promotes the health and well-being of both mothers and infants. However, migration-related experiences, socioeconomic conditions, and access to breastfeeding support may influence breastfeeding attitudes and practices among immig...

A Bounded, Memoryless, Cycle-Slip-Free, and Reliability-Weighted Angular Framework for Multi-Harmonic Signal Analysis

Comparing scale-parameter ratios in digital signal processing via unbounded logarithmic axes or periodic phase-based comparators introduces structural costs, including unbounded axis growth and cycle slips. We introduce GTFS, a bounded, nonperiodic angular projection mapping an u...

Consent architecture in biobanking: ethical attitudes and consent preferences among people with cancer and caregivers

Ethical and socially accountable biobanking depends on public trust and informed consent. Understanding how people with cancer and caregivers view biospecimen use is essential for designing consent models that respect autonomy and reflect cultural values. This study examined cons...

Predicting Lentil Seed Yield from Agronomic Traits Using a Foundation-Augmented Machine Learning Ensemble

Accurate agricultural yield prediction is crucial for crop management and data-driven decision-making. This study proposes a machine learning framework for predicting total lentil seed yield using 264 observations collected during a single growing season at one location in Sivas,...

A resource-aware framework for energy and bandwidth efficient IoT intrusion detection using lightweight federated learning over SDN

The rapid growth of Internet of Things (IoT) deployments has widened the network attack surface while increasing the cost of centralised intrusion detection, particularly when raw traffic must be moved to remote servers. We propose HFL-SDN-IDS, a hierarchical, resource-aware fram...

Preschool Teachers as Potential Early Identifiers of Pediatric Voice Disorders: Awareness and Referral Practices

Purpose: Early identification of voice disorders is essential. Preschool teachers interact with children daily and may play an important role in recognizing early signs of voice problems and referring children to appropriate health professionals. The aim of this study was to exam...

Barriers to research engagement among medical students in Türkiye: the role of environmental factors

Abstract Background Medical student participation in structured research activities during undergraduate education appears to remain limited and the factors underlying this limited participation are not yet fully understood. Existing validated questionnaires were not suitable for...

Association of Gastric Microbiota with Gastric Cancer in Patients Infected with Helicobacter pylori

Background: The association between Helicobacter pylori and the resident gastric microbiota plays a critical role in gastric carcinogenesis; however, the specific microbial alterations accompanying the transition from chronic inflammation to malignancy remain to be fully elucidat...

Synthesis, Biological Evaluation, Molecular Docking and DFT Studies of Electronically Tuned Benzylidene-Based Schiff Bases

Inspired by the medicinally relevant stilbene scaffold, a series of six electronically tuned benzylidene-based Schiff base derivatives were designed, synthesized, and characterized by FT-IR, 1H NMR, 13C NMR, and ESI-MS analyses. The biological properties of the synthesized compou...

Evaluating airline service quality using a Pythagorean fuzzy multi-criteria group decision-making framework

Growing competition in the airline industry has made service quality evaluation an increasingly important yet complex Multi-Criteria Group Decision-Making (MCGDM) problem. Service quality depends on several interrelated attributes, and passenger or expert assessments are often su...

Absorbable tacker fixation versus non-fixation in totally extraperitoneal inguinal hernia repair: a prospective randomized study on postoperative pain and quality of life

The role of mesh fixation in laparoscopic totally extraperitoneal (TEP) inguinal hernia repair remains controversial. While fixation may increase postoperative pain, concerns about recurrence in larger defects prevent its complete abandonment. This study aimed to compare absorbab...

Composite Uric Acid Index for Prediction of Significant Coronary Stenosis on Computed Tomography Angiography

OBJECTIVE: A recently proposed uric acid index combining fasting glucose, triglycerides, and uric acid has shown promise in cardiovascular risk stratification. It was assessed whether the index could predict significant coronary artery stenosis (≥50%) on coronary computed tomogra...

An Intelligent Deep Reinforcement Learning Framework for Cost-Efficient and Energy-Aware Cloud Resource Management

The rapid growth of cloud computing and Internet of Things (IoT) applications has intensified the need for efficient resource allocation, energy management, and cost optimization in large-scale data centers. Traditional optimization and machine learning approaches, while effectiv...

Efficacy of early blood purification on serum inflammatory mediators in severe acute pancreatitis: a systematic review and meta-analysis

Severe acute pancreatitis (SAP) is the most critical form of acute pancreatitis (AP), characterized by a dysregulated systemic inflammatory response that drives early organ failure and mortality. Current management remains mainly supportive. Early blood purification (EBP) has bee...

From Germinated Pseudocereals to Functionalized Bread: The Role of the Food Matrix in Protein and Phenolic Bioaccessibility

Despite the well-documented nutritional benefits of germinated pseudocereals, whether these benefits are preserved following bread incorporation remains unexplored. Bread incorporating germinated quinoa, amaranth, and buckwheat at 15% and 30% substitution was evaluated alongside...

CompACT: Comprehensive Assessment of Acceptance and Commitment Therapy Processes’ Validity and Relıability in Turkish Adolescents

Background: The Comprehensive Assessment of Acceptance and Commitment Therapy Processes (CompACT) is a self-report scale used to assess psychological flexibility. In the present study, we examined the psychometric properties of CompACT in Turkish adolescents.Methods: The study in...

Epidural Electrical Stimulation Within an Integrated Rehabilitation Pathway for Traumatic Cervical Spinal Cord Injury: Safety and 12-Month Functional Outcomes

Background/Objectives: Epidural electrical stimulation (EES) is an investigational, off-label neuromodulation strategy used adjunctively with rehabilitation in chronic spinal cord injury (SCI), but safety and longitudinal functional data specific to traumatic cervical SCI remain...

High‐Order Singularity‐Corrected Sum‐of‐Exponentials Product Integration for Second‐Kind Fractional Volterra Equations With Modulated Weakly Singular Kernels

ABSTRACT Weakly singular fractional Volterra equations require both accurate treatment of the algebraic kernel singularity and efficient evaluation of the growing history term. We develop a singularity‐corrected sum‐of‐exponentials product‐integration framework for second‐kind eq...

Glucosamine functionalized multi-walled carbon nanotubes as potential antibacterial molecules

Antibiotic resistance represents a critical global health challenge driven by the widespread misuse of antimicrobials and the rapid evolution of multidrug-resistant pathogens. Conventional antibiotics are increasingly limited by poor stability, low bioavailability, toxicity, and...