Istanbul University-Cerrahpaşa

Pharmacokinetics of meloxicam following intramuscular, subcutaneous, and oral administration in white storks (Ciconia ciconia)

Abstract Background Meloxicam (MLX) is a preferential cyclooxygenase-2 inhibitor widely used in avian medicine as an anti-inflammatory agent. Despite marked interspecific variability in avian drug disposition, no pharmacokinetic data are available for MLX in the white stork ( Cic...

Nonadditive gene expression and reduced homoeolog expression bias in an intraspecific hexaploid wheat hybrid

Abstract Background Intraspecific hybridization in allopolyploid plants can generate additive and nonadditive changes in gene expression through interactions between divergent parental genomes. However, how it simultaneously affects gene expression and the relative expression of...

Assesment of Dental Caries Based on CAST, ICDAS II and Nyvad’s Criteria in Primary Molars

Purpose: This study aims to test and compare three caries measurement methods, the Caries Assessment Spectrum and Treatment (CAST), the International Caries Detection and Assessment System (ICDAS), and the Nyvad’s criteria, to assess the degree and severity of dental caries in pr...

Diagnostic disclosure to parents of children with developmental disabilities: Experiences and communication preferences

Aim: Communication during developmental disability diagnosis disclosure may influence parents’ emotional responses, understanding, and engagement with care. This study investigated parents’ experiences and preferences regarding disclosure and their evaluations of the communicatio...

Speckle aware attention and multi scale pooling for robust breast ultrasound lesion classification across multiple benchmarks

Breast ultrasound (BUS) is widely used for lesion assessment, yet automatic benign–malignant classification remains challenging owing to speckle noise, weak boundaries, and cross-scanner heterogeneity. We propose SUA-Net, a compact framework that augments an EfficientNet-B0 backb...

Surgical outcomes of constrictive pericarditis and exploratory associations with inflammatory features: a 17-year single-center experience

Constrictive pericarditis (CP) remains a challenging disease with evolving etiological patterns and increasing emphasis on phenotype-based management. Pericardiectomy is the definitive treatment for CP. However, contemporary data on the etiological spectrum and the clinical relev...

Towards resilient forest establishment in Europe: functional traits, genetic diversity and multifunctional design

Abstract Forest restoration and afforestation across Europe are accelerating, yet the decision-making processes governing forest establishment remain unevenly examined, especially from a biodiversity perspective. Considering this and the global environmental changes of climate sh...

Association of AP-1/c-Jun with IL-6 and IL-8 expression in hepatocellular carcinoma: attenuating effects of metformin in vitro

Objective: Hepatocellular carcinoma remains a major contributor to cancer mortality worldwide, with low five-year survival rates despite treatments, underscoring the need for more effective and targeted therapies. Metformin, an oral antihyperglycemic agent, has gained attention f...

Recent Advances and Open Challenges in Mitigating Inference-Time Attacks on Large Language Models

The rapid integration of Large Language Models into high-stakes domains has elevated inference-time attacks into a primary security concern for production deployments. These attacks are adversarial techniques that exploit models exclusively through their input–output interface. T...

Cross-cultural adaptation and validation of the Localised Scleroderma Quality of Life Instrument (LoSQI): an international study

Juvenile localised scleroderma (jLS) is a rare disease which impacts negatively on health-related quality of life (HRQoL). We aimed to undertake the cross-cultural adaptation and validation of a novel disease-specific HRQoL measure, the Localised Scleroderma Quality of Life Instr...

Machine learning-based winner prediction in elite kickboxing: a technical-tactical performance analysis

To develop and validate machine learning models for predicting match outcomes in elite kickboxing based on technical-tactical performance indicators and to identify the key variables distinguishing winners from defeated athletes. Video analysis was conducted on 142 elite kickboxi...

Integrated Prognostic Stratification After Perioperative FLOT in Gastric and Gastroesophageal Junction Adenocarcinoma: A Multicenter Real-World Study

Background/Objectives: Outcomes after perioperative FLOT for gastric and gastroesophageal junction adenocarcinoma remain variable, even among patients treated with curative intent. Although postoperative pathological findings are central to risk assessment, they do not fully capt...

Factors associated with mortality in Staphylococcus aureus bacteremia: the role of infectious diseases consultation

This study aimed to determine the predictors of 14th and 28th day mortality in Staphylococcus aureus bacteremia and to evaluate the risk factors of methicillin-resistant S. aureus (MRSA). Our study, designed as a single-center retrospective observational study, included adult pat...

NBN rs1805794 Polymorphism Increases the Predictive Performance of Machine Learning Models for Multiple Chronic Toxicities in Head and Neck Cancer Survivors Treated with Definitive Radiotherapy ± Chemotherapy

Objective: While advancements in radiotherapy and systemic agents have significantly improved survival rates in head and neck squamous cell carcinoma (HNSCC), managing long-term, treatment-induced toxicities remains a critical clinical challenge. This study aimed to develop a per...

Validation of the Turkish parent-reported Diabetes Eating Problem Survey-Revised (DEPS-R) for screening disordered eating behaviors in adolescents with Type 1 diabetes

Adolescents with Type 1 diabetes are at increased risk of eating disorders, which have been associated with suboptimal metabolic control and an increased risk of complications. Reliable and culturally adapted screening tools are essential for early identification. However, the pa...

Bridging Parental Perceptions and Experiences of Family‐Centered Care in the Pediatric Intensive Care Unit: A Mixed‐Methods Study

AIM: To examine parents' perceptions and experiences of family-centered care in a pediatric intensive care unit and explore how communication, participation in care, and contextual factors shape these experiences. DESIGN: An explanatory sequential mixed-methods design was used. M...

Crowe severity and femoral stem geometry are associated with lower-limb alignment after total hip arthroplasty for unilateral developmental dysplasia of the hip–related secondary osteoarthritis: valgus alignment trajectories

BACKGROUND: Total hip arthroplasty (THA) for secondary osteoarthritis related to developmental dysplasia of the hip (DDH) restores hip mechanics. We aimed to quantify pre-to-postoperative changes in ipsilateral knee and global lower-limb alignment after unilateral THA to determin...

Association between long-term exposure to air pollution and blood pressure in children: an updated systematic review and meta-analysis

Abstract Introduction Ambient air pollution is a modifiable environmental exposure that may contribute to early cardiovascular risk. Although long-term exposure has been linked to blood pressure (BP) dysregulation, research on its effects in children remains limited, despite thei...

Patient-level topology-aware graph transformer for breast histopathology classification

Progress in computational pathology is limited not only by model architecture, but also by evaluation design. In breast histopathology benchmarks such as BreaKHis, multiple correlated image tiles often originate from the same patient; consequently, image-wise splits can inflate p...

A Novel Piezoelectric Tip for Dorsal Hump Resection: A Randomized Clinical Trial in Primary Open Septorhinoplasty

Objective: To compare the performance of a novel piezoelectric tip with that of a conventional tip for dorsal hump resection in primary open septorhinoplasty, with the hypothesis that the new design would shorten resection time without increasing postoperative edema, ecchymosis,...