Istanbul University-Cerrahpaşa

Fresh-semen proAKAP4 concentration predicts sperm cryotolerance independently of conventional semen quality across three goat breeds

Abstract Cryopreservation compromises sperm quality, yet conventional semen analysis poorly predicts which ejaculates will withstand freezing. proAKAP4, a sperm-specific structural protein, is a candidate freezability biomarker, but is usually measured after thawing. We tested wh...

When platelets reach a million: insights from hematologists

The management of patients with essential thrombocythemia (ET) and extreme thrombocytosis (ExT) remains plagued by several unresolved issues. Therefore, we conducted a web-based survey to better understand hematologists’ clinical approaches to ExT and to compare them with respons...

Empathy and Violence Tendency: The Mediating Roles of Emotional Intelligence and Masculine Behaviour

Violence represents a significant psychosocial problem affecting both individuals and societies. This cross-sectional study examined the relationship between empathy and violence tendency and investigated the mediating roles of emotional intelligence, emotional regulation, and ma...

Real-world outcomes of children with first relapsed acute lymphoblastic leukemia treated according to the ALL-IC REL 2016 guideline in Türkiye

Relapsed acute lymphoblastic leukemia (ALL) remains a major challenge in pediatric oncology, particularly where access to modern immunotherapies is limited. This national multicenter study evaluated real-world outcomes of children with first relapsed ALL treated according to the...

Composite Uric Acid Index for Prediction of Significant Coronary Stenosis on Computed Tomography Angiography

OBJECTIVE: A recently proposed uric acid index combining fasting glucose, triglycerides, and uric acid has shown promise in cardiovascular risk stratification. It was assessed whether the index could predict significant coronary artery stenosis (≥50%) on coronary computed tomogra...

Development and internal validation of a prognostic nomogram for resected non-metastatic Siewert type II–III gastroesophageal junction adenocarcinoma: a single-center retrospective study

Prognostic assessment of resected gastroesophageal junction (GEJ) adenocarcinoma relies primarily on American Joint Committee on Cancer (AJCC) tumor–node–metastasis (TNM) staging, which does not incorporate comorbidity burden, lymph node ratio (LNR), signet-ring cell histology, o...

Do Free-Living Amoebae Serve as a Shelter for Helicobacter pylori in Istanbul’s Water Treatment Plants?

Understanding microbial survival mechanisms in aquatic environments is essential for public health. This study investigates the potential role of free-living amoebae (FLA) as environmental shelters for Helicobacter pylori in Istanbul’s potable and wastewater treatment plants. Sam...

Evaluation of the accuracy and reproducibility of large language models (ChatGPT, DeepSeek, Gemini) in responding to patient-centered lipedema questions

Background Lipedema is a frequently misdiagnosed chronic condition that significantly impacts patients’ quality of life. As artificial intelligence (AI)-based large language models (LLMs) become increasingly integrated into healthcare communication, their accuracy and consistency...

Effect of Cold Needle on Injection Complications

Propose: This study aimed to evaluate the effects of cold needle (0–2°C) application on pain intensity, ecchymosis rate, and patient comfort during subcutaneous (SC) insulin injections. The hypotheses; When administering insulin via the SC route, a cold needle temperature reduces...

Effect of education on oral antiviral use on medication adherence and quality of life in patients with chronic hepatitis B: a randomised trial

Background: Adherence to oral antiviral therapy is essential to reduce progression from chronic hepatitis B (CHB) to cirrhosis and hepatocellular carcinoma. Aim: To evaluate the effect of education on oral antiviral use on medication adherence and quality of life (QoL) in patient...

Patient Expectations, Satisfaction and Perceptions of Specialization in Family Medicine: A Cross-Sectional Study from a Health Literacy Perspective in Türkiye

Background/Objectives: Patient expectations, satisfaction, and perceptions of specialization in family medicine are critical to improving primary care, and health literacy (HL) shapes patients’ engagement with health information. This study assessed these domains and their relati...

Miocene to Quaternary Tectonostratigraphic Evolution of the Northern Section of the Burdur‐Fethiye Shear Zone, South‐Western Türkiye

ABSTRACT The Burdur‐Fethiye Shear Zone (BFSZ) is a deformation zone accommodating strain partitioning between extensional and compressional domains in south‐western Türkiye. It exhibits a broad, linear geometry with a width of ~75–90 km and extends from Şuhut‐Çay to Sarıgerme‐Gel...

Investigation of Dyeing and Fastness Behaviors of Bio-Mordanted Wool Fabric Dyed with Black Carrot Natural Dye

In this study, the coloring of wool fabric samples using a natural dye extracted from black carrots has been investigated using the ultrasonic-assisted method. The natural dye was extracted from black carrots with conventional heating. Before the dyeing process, the samples were...

Orbitozygomatic-transsylvian approach to the insula: microsurgical anatomy and endoscopic correlation using the fiber-separation technique

Insular surgery remains technically demanding because of the region’s deep location and intimate relationships with the middle cerebral artery complex and surrounding white matter pathways. Safe resection requires precise understanding of vascular landmarks and subcortical functi...

How appropriate are ChatGPT-5’s answers to acne questions?

Online conversational tools have become increasingly common sources of health information, with many patients seeking acne advice through such platforms. Although they may enhance awareness and encourage early consultation, their medical reliability remains uncertain. Because acn...

Decodable, Compositional Affect-Like Representations in a Self-Taught Agent and Pretrained Language Models

We study whether emotion-like internal variables arise without hand-coding in artificial networks, and whether affect-related representations share common geometric structure across systems. In a self-taught homeostatic reinforcement-learning agent - trained only with a well-bein...

The latent construct of teacher care: relations with professional attitude, subjective well-being, and burnout among primary school teachers

This study aims to investigate the relationship between the phenomenon of teacher care and the outcomes of attitude, well-being, and burnout to better understand these constructs. The study was conducted in 2024–2025 on a sample of 498 teachers. In this study, the Teacher Care Sc...

Fenugreek ( Trigonella foenum‐graecum L.) as a functional food associated with improved heat‐stress survival in Caenorhabditis elegans

Abstract BACKGROUND Fenugreek ( Trigonella foenum‐graecum L.) is widely consumed as a functional food across Mediterranean, Middle Eastern, and South Asian cultures and has long been valued in traditional diets for its health‐promoting properties. Although fenugreek contains dive...

Management and Clinical Outcomes of Liver Hemangiomas: A Retrospective Comparative Study of Transcatheter Arterial Embolization and Surgery

Background and Objectives: Hemangiomas are the most common benign tumors of the liver. Surgical options such as enucleation, segmentectomy, and hepatectomy are the primary treatment choices, though the morbidity and complication rates remain high. Transcatheter arterial embolizat...

Quality and safety of large language model–generated medication review outputs in geriatric pharmacotherapy: a two-stage comparative vignette-based benchmark evaluation

Abstract Background Polypharmacy and multimorbidity make medication review in older adults a high-stakes clinical task. Large language models (LLMs) may support medication review, but whether item-level concordance with explicit prescribing criteria reflects expert-rated reasonin...