Istanbul University-Cerrahpaşa

Recent Advances and Open Challenges in Mitigating Inference-Time Attacks on Large Language Models

The rapid integration of Large Language Models into high-stakes domains has elevated inference-time attacks into a primary security concern for production deployments. These attacks are adversarial techniques that exploit models exclusively through their input–output interface. T...

Cross-cultural adaptation and validation of the Localised Scleroderma Quality of Life Instrument (LoSQI): an international study

Juvenile localised scleroderma (jLS) is a rare disease which impacts negatively on health-related quality of life (HRQoL). We aimed to undertake the cross-cultural adaptation and validation of a novel disease-specific HRQoL measure, the Localised Scleroderma Quality of Life Instr...

Integrated Prognostic Stratification After Perioperative FLOT in Gastric and Gastroesophageal Junction Adenocarcinoma: A Multicenter Real-World Study

Background/Objectives: Outcomes after perioperative FLOT for gastric and gastroesophageal junction adenocarcinoma remain variable, even among patients treated with curative intent. Although postoperative pathological findings are central to risk assessment, they do not fully capt...

Machine learning-based winner prediction in elite kickboxing: a technical-tactical performance analysis

To develop and validate machine learning models for predicting match outcomes in elite kickboxing based on technical-tactical performance indicators and to identify the key variables distinguishing winners from defeated athletes. Video analysis was conducted on 142 elite kickboxi...

Factors associated with mortality in Staphylococcus aureus bacteremia: the role of infectious diseases consultation

This study aimed to determine the predictors of 14th and 28th day mortality in Staphylococcus aureus bacteremia and to evaluate the risk factors of methicillin-resistant S. aureus (MRSA). Our study, designed as a single-center retrospective observational study, included adult pat...

NBN rs1805794 Polymorphism Increases the Predictive Performance of Machine Learning Models for Multiple Chronic Toxicities in Head and Neck Cancer Survivors Treated with Definitive Radiotherapy ± Chemotherapy

Objective: While advancements in radiotherapy and systemic agents have significantly improved survival rates in head and neck squamous cell carcinoma (HNSCC), managing long-term, treatment-induced toxicities remains a critical clinical challenge. This study aimed to develop a per...

Validation of the Turkish parent-reported Diabetes Eating Problem Survey-Revised (DEPS-R) for screening disordered eating behaviors in adolescents with Type 1 diabetes

Adolescents with Type 1 diabetes are at increased risk of eating disorders, which have been associated with suboptimal metabolic control and an increased risk of complications. Reliable and culturally adapted screening tools are essential for early identification. However, the pa...

Bridging Parental Perceptions and Experiences of Family‐Centered Care in the Pediatric Intensive Care Unit: A Mixed‐Methods Study

AIM: To examine parents' perceptions and experiences of family-centered care in a pediatric intensive care unit and explore how communication, participation in care, and contextual factors shape these experiences. DESIGN: An explanatory sequential mixed-methods design was used. M...

Crowe severity and femoral stem geometry are associated with lower-limb alignment after total hip arthroplasty for unilateral developmental dysplasia of the hip–related secondary osteoarthritis: valgus alignment trajectories

BACKGROUND: Total hip arthroplasty (THA) for secondary osteoarthritis related to developmental dysplasia of the hip (DDH) restores hip mechanics. We aimed to quantify pre-to-postoperative changes in ipsilateral knee and global lower-limb alignment after unilateral THA to determin...

Association between long-term exposure to air pollution and blood pressure in children: an updated systematic review and meta-analysis

Abstract Introduction Ambient air pollution is a modifiable environmental exposure that may contribute to early cardiovascular risk. Although long-term exposure has been linked to blood pressure (BP) dysregulation, research on its effects in children remains limited, despite thei...

Patient-level topology-aware graph transformer for breast histopathology classification

Progress in computational pathology is limited not only by model architecture, but also by evaluation design. In breast histopathology benchmarks such as BreaKHis, multiple correlated image tiles often originate from the same patient; consequently, image-wise splits can inflate p...

A Novel Piezoelectric Tip for Dorsal Hump Resection: A Randomized Clinical Trial in Primary Open Septorhinoplasty

Objective: To compare the performance of a novel piezoelectric tip with that of a conventional tip for dorsal hump resection in primary open septorhinoplasty, with the hypothesis that the new design would shorten resection time without increasing postoperative edema, ecchymosis,...

Separation Anxiety in Emerging Adults: The Role of Attachment Styles and Personality Traits

Objective To examine childhood and adult separation anxiety symptoms and their associations with attachment styles, personality traits, and sociodemographic factors among university students.Methods This cross-sectional study included 200 first-year university students. Attachmen...

Blood Pressure and Angina-Related Health Status During Benidipine Therapy: A Multicenter Real-World Cohort Study

Background: Benidipine is a long-acting calcium channel blocker used for the treatment of hypertension and chronic coronary syndrome. Although it effectively lowers blood pressure (BP), the relationship between BP reduction and improvement in angina-related health status during b...

The effect of digital literacy training for women in menopause on health literacy and quality of life: A randomized controlled trial

Menopause is a critical stage in a woman’s life and is often accompanied by multiple physical and psychosocial challenges. Access to accurate health information is essential for symptom management and well-being; however, increasing reliance on digital platforms may expose women...

Affective Organizational Commitment Links Job Satisfaction to Quiet Quitting in Healthcare Workers: The Amplifying Role of Career Engagement

Background/Objectives: This study examined the relationships among job satisfaction, affective organizational commitment, career engagement, and quiet quitting in healthcare workers. Specifically, we tested a moderated mediation model in which affective organizational commitment...