IRCCS Humanitas Research Hospital

Clinical Remission is Achievable for Adult Patients with Severe Asthma Receiving Mepolizumab: A European Retrospective Chart Review

The introduction of precision therapy in severe asthma is shifting treatment goals from asthma control towards the more ambitious target of clinical remission. This study evaluated clinical remission in patients with severe asthma receiving mepolizumab in Europe. A retrospective,...

Shockwave‐Induced Myoblast Exosome‐Like Vesicles: Emerging Drivers of Muscle Regeneration

ABSTRACT Exosomes, a subset of nanosized extracellular vesicles, are key mediators of intracellular communication that show growing therapeutic potential in skeletal muscle regeneration. By shuttling bioactive cargoes between cells, they modulate recipient cell behavior, influenc...

Real-World Antibiotic Strategies for Multidrug-Resistant Pseudomonas aeruginosa: Evidence from the Italian SUSANA Multicentre Study

Background/Objectives: Multidrug-resistant (MDR) Pseudomonas aeruginosa pneumonia and bloodstream infections (BSI) remain challenging because of their severity, limited therapeutic options, and high mortality, despite the availability of novel β-lactam-based agents. We aimed to d...

Announcing The Lancet Regional Health—Europe series on the alarming surge of early-onset colorectal cancer: a multidisciplinary call to action

The rising incidence of early-onset colorectal cancer (EOCRC), defined as a diagnosis in adults younger than 50 years, has emerged as a critical global public health challenge.1 While colorectal cancer (CRC) rates in older populations have stabilized or declined due to successful...

The Hsd17b13P260S patient variant knock-in male mouse model provides translational insights into HSD17B13 biology

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disease that can progress to metabolic dysfunction-associated steatohepatitis (MASH), a condition marked by inflammation and fibrosis that increases the risk of cirrhosis, liver failu...

Ringing the Bell in Cancer Care: A Scoping Review of Patients’, Caregivers’, and Healthcare Professionals’ Experiences and Implications for Oncology Nursing

BACKGROUND: Bell-ringing rituals mark the end of active cancer treatment in oncology settings worldwide. Despite their growing prevalence, their emotional and clinical implications across patients, caregivers, and healthcare professionals remain underexplored. OBJECTIVE: To map a...

Comparative Efficacy Of Different Computer-Aided Detection Products in Colonoscopy: A Network Meta-Analysis Of Randomized Controlled Trials.

Background and aims: Multiple computer-aided detection (CADe) systems have been developed to improve adenoma detection during colonoscopy, but their comparative efficacy and consistency of effect remain uncertain. This network meta-analysis aimed to compare the efficacy of differ...

Endovascular Thrombectomy for Cerebral Venous Thrombosis: Current Status and Future Directions

Abstract Cerebral venous thrombosis (CVT) represents a relatively rare cause of stroke, yet it carries an overall rate of death or dependency of up to 15%. The mainstay of its management is therapeutic anticoagulation, either subcutaneously or intravenously in the acute phase, fo...

Readmission to hospital after thoracic trauma: better safe than sorry! the predictive read score

Thoracic trauma accounts for approximately 10–15% of trauma admissions and contributes substantially to trauma-related morbidity and mortality. Readmission rates for thoracic trauma have not been investigated thus far; thus, the purpose of this retrospective study is to reduce pa...