Instituto Politécnico Nacional

Determination of the metric of a Schwarzschild black hole surrounded by a halo of dark matter

Abstract Following the landmark acquisition of the first image of a black hole, systems comprising a black hole enveloped by a dark matter halo have attracted considerable attention. This work implements a novel method to analyze the structure of a system composed of a Schwarzsch...

Lightweight Sensor Data Encryption on ESP32 Using the Pi Number for Dynamic Operations

Since intercepted sensor data can reveal user activities, lightweight cryptography is essential for protecting information in resource-constrained devices. Although ARX-based lightweight schemes offer high computational efficiency, their lack of inherent non-linear substitution a...

A q-deformed deterministic gradient framework generalizing affine projection adaptive filters

Purpose This work proposes a q-deformed deterministic gradient framework that generalizes affine projection adaptive filters by embedding a deformation of the classical gradient operator into a fully deterministic formulation. Design/methodology/approach By embedding the q-gradie...

Size Classification for Software Maintenance Projects Through a Simplified Minimalist Machine Learning Algorithm

In the software engineering field, the size of projects is used as explanatory variable for predicting the effort, duration, defects, costs, or risks of a project. Thus, the software project size has been considered the most influential factor. A systematic mapping study on the u...

Experimental biofilm vaccines for fish aquaculture: an overview

Biofilm vaccines in fish are a trending approach to fighting bacterial diseases. Pathogens, including Aeromonas spp., Vibrio spp., Photobacterium spp., and Streptococcus spp., have been studied for planktonic- and biofilm-derived vaccines. These vaccines have demonstrated safe im...

Multi-criteria kinetic modeling of kerogen hydrothermal conversion: assessing network complexity and model selection

The kerogen-rich oil shale deposits constitute a strategically vital unconventional resource base. However, suitable kinetic studies that represent the reactions for developing appropriate technologies are scarce. This study systematically evaluates the predictive accuracy of kin...

Online algebraic identification–based trial-weight-free modal balancing of asymmetric rotor–bearing systems

Asymmetric rotor–bearing systems exhibit parametric excitation and complex vibration behavior due to unequal stiffness along their principal axes, which significantly complicates conventional balancing procedures. Most existing methodologies require trial weights and multiple rot...

Molecular Dynamics Simulations Reveal Structural Changes Associated with the ABCA1 R230C Functional Variant

The ATP-binding cassette transporter A1 (ABCA1) functional variant R230C (rs9282541) is associated with low plasma HDL-C levels, yet its atomic-scale mechanism remains unclear. We evaluated the structural and dynamic impact of R230C compared to wild-type (WT) ABCA1 using 200 ns m...

Aloe-Emodin Modifies Adipogenic Genes and the Expression of miR-143 and miR-155 in 3T3-L1 Cells

Adipogenesis is crucial for maintaining energy homeostasis, as it facilitates the differentiation of mesenchymal stem cells into adipocytes. This process is transcriptionally regulated by key factors including PPARγ and C/EBPβ, alongside FABP4 during lipogenesis. However, it is n...

Therapeutic Potential of Berberine in Obesity-Associated Neuroinflammation Through Shared Molecular Pathways: TLR4/NF-κB/MAPK, ROS/NRF2 and NLRP3

Obesity is recognized as a pathological condition that induces chronic low-grade systemic inflammation capable of affecting multiple organs, including the central nervous system, thereby promoting neuroinflammation. Although adipose and neural tissues differ in their structural a...

Anatomical Asymmetry in Adipose Tissue Thickness Alters Heat Transfer During Superficial Thermotherapy: A Computational and Experimental Study

Computer models and protocols commonly used for superficial thermotherapy assume anatomically symmetric tissue geometries. However, anatomical variability, particularly the variability of the adipose tissue thickness, may have a significant impact on heat transfer and cause non-u...

A Multiscale Dynamical-Systems Model of Measles Immuno-Epidemiology with ODE-to-Cellular-Automaton Coupling

Measles virus infection couples nonlinear processes across biological scales, including within-host viral amplification, immune-cell depletion, delayed adaptive control, persistent viral RNA, heterogeneous host severity and vaccination-dependent population spread. A multiscale ma...

Public Health Policy Responses to Population Aging in Mexico: A Rights-Based and Socio-Legal Approach

Background/Objectives: Population aging represents a major social and public health challenge in Latin America. Mexico has made significant advances in regulatory and policy frameworks. Notable progress includes accession to the Inter-American Convention on Protecting the Human R...

Non-Clinical Evaluation of the Anti-PD-1 Antibody UDIZ-007

Background/Objectives: Programmed cell death protein 1 (PD-1) is a key immune checkpoint that suppresses anti-tumor T-cell responses and is an established target for cancer immunotherapy. UDIZ-007 is a fully human anti-PD-1 antibody that blocks PD-1/PD-L1 and PD-1/PD-L2 interacti...

Soil environmental background values of potentially toxic elements in Topsoil’s from Karst environments; the case of Peninsula of Yucatan Mexico

Abstract Accurate assessment of soil contamination by potentially toxic elements requires knowledge of local background values; only in this way can false positives or negatives be avoided. The objective of this study was to define environmental background concentrations of poten...

Coupled Fourier Neural Operator and Vision Transformer Bottleneck for Parameter-Efficient Brain Tumor Segmentation

Segmenting brain tumor subregions in multimodal MRI is difficult due to severe class imbalance and scarce annotated data, and current state-of-the-art models require 21.3–31 million parameters to reach a whole-tumor Dice of 0.906–0.921. We propose a parameter-efficient 2D encoder...

Design, synthesis, drug-likeness, and molecular dynamics evaluations of monobrominated amathamide G analogs as potential ligands for D2-like dopamine receptors

Abstract Dopamine receptors (DRs) are key modulators of physiological and behavioral responses in the central nervous system (CNS), playing a major role in psychotic disorders. Among these, the D2-like members D2R, D3R and D4R are particularly attractive therapeutic targets for t...

Performance Comparison of Classical and Robust Control Strategies for a Lower-Limb Rehabilitation Exoskeleton

Lower-limb rehabilitation exoskeletons have emerged as a promising complementary technology to conventional therapy, enabling repetitive, intensive, and personalized gait training. However, achieving accurate trajectory tracking while maintaining robustness against parametric unc...

Cross-modal audio-text attention for multimodal multitask speech emotion recognition in low-resource Urdu

Speech Emotion Recognition (SER) in low-resource languages remains challenging due to limited annotated data, speaker variability, and the multimodal nature of emotional expression. This paper repositions established components wav2vec 2.0, XLM-R, cross-modal attention, and multi...

Thermal and optical characterization, as well as photostability assessment of sunscreens by using photoacoustic and photopyroelectric techniques

Sunscreens are fundamental public health tools for mitigating the harmful effects of ultraviolet (UV) radiation on the skin. UVA radiation reaches the Earth's surface in greater proportion, contributing to photoaging and skin carcinogenesis. In this context, the efficacy of sunsc...