Institute of Science Tokyo

Dry and wet strengthening techniques for timber frames with various infills

Paianta houses belong to the traditional vernacular typology in Romania and have, as a main feature, the presence of the timber frame (posts, beams, and diagonals) infilled with several types of materials, such as fired earth brick masonry, earth and straw mix, wattle and daub, o...

YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutations

Abstract Large-scale genome sequencing analyses have identified driver gene mutations (DGMs) in most cancers as well as their associated tumorigenic mechanisms. However, a small fraction of cancers are not positive for these canonical DGMs, leaving the mechanisms underpinning the...

Griffiths Inequalities and Gibbs–Bogoliubov Inequality for General Gauge Glasses with Gaussian Disorder on Nishimori Line

We consider a class of gauge glass models with Gaussian disorder on the Nishimori line, including the Ising spin glass, the XY gauge glass, the Z q gauge glass, and the gauge-invariant Potts model. We prove that the first and second Griffiths inequalities hold for these models on...

Breaking the Orthogonality Barrier in Quantum LDPC Codes

Classical low-density parity-check (LDPC) codes are a widely deployed and well-established technology, forming the backbone of modern communication and storage systems. It is well known that, in this classical setting, increasing the girth of the Tanner graph while maintaining re...

Exploratory spatial transcriptomic analysis of compartment-specific recurrence-associated gene expression in gastric cancer

We hypothesized that the prognostic value of immune and stromal gene expression is spatially dependent—specifically, signals driving homeostasis in the superficial mucosa may differ functionally from those at the deep invasive front. We analyzed formalin-fixed paraffin-embedded s...

Podocyte injury damages podocytes in chimeric organoids

Abstract We have previously shown that injury to a subset of podocytes can trigger secondary damage in neighboring podocytes, but whether this phenomenon depends on direct intercellular interaction is unknown. To address this, kidney organoids were generated from nephron progenit...

Decoupling plasma-compatible CO-to-graphitic-carbon conversion from H2-rich feeding over Fe–Mn/Al2O3

CO-to-graphitic-carbon conversion is the decisive downstream step in CO 2 –CO–C chemical looping, linking CO 2 fixation to sustainable nanocarbon production. However, this gas-to-solid transformation typically relies on H 2 -rich feeds containing 20–50% H 2 to maintain catalytic...

Analysis of Critical Points in a Permutation Model on Hierarchical Lattices by Real-Space Renormalization Group

The permutation model is a classical spin system where elements of the symmetric group interact with one another. The partition function of this model is directly related to the entanglement structure of random quantum circuits and random tensor networks. In these contexts, the e...

Immediate Grammar is not Free: A Time-Constrained Grammar

This short paper examines word order in Immediate Grammar, a component of the Process Grammar Model. Although phrase order in spoken Japanese appears relatively free, examples involving reaction, discovery, self-correction, recall, confirmation, and continuation show that not all...

Immediate Grammar is not Free: A Time-Constrained Grammar

This short paper examines word order in Immediate Grammar, a component of the Process Grammar Model. Although phrase order in spoken Japanese appears relatively free, examples involving reaction, discovery, self-correction, recall, confirmation, and continuation show that not all...

A skeletal–smooth muscle interface mediates levator ani attachment to the rectum and vagina: a macroscopic and histological study

Abstract We aimed to clarify the attachment architecture between the levator ani and the rectum and vagina using integrated macroscopic and histological analyses of human pelvic floor specimens. Macroscopic dissection consistently demonstrated whitish soft tissue at the interface...

Finite-Basis Duality Estimate for the Surface-Code Threshold under Correlated Bit-Flip Errors

We apply finite-basis duality to a statistical-mechanical model introduced by Chubb and Flammia for the surface code under spatially correlated bit-flip noise, for which their mapping gives a random-bond Ising model with both two-body edge interactions and four-body face interact...

The history of enzyme evolution embedded in metabolism.

Whereas phylogenetic reconstructions are a primary record of protein evolution, it is unknown whether the deep history of enzymes is encoded at higher levels of biological organization. Here, we demonstrate that the emergence and reuse history of enzymatic folds is embedded withi...

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPS-CMs) have great potential in regenerative medicine. However, iPS-CMs are immature and resemble fetal cardiomyocytes, restricting their application. Fetal cardiomyocytes in the human heart are diploid and proli...

An Eleven-Dimensional Geometric Reading of Lenz's 6π^5 Approximation to the Proton–Electron Mass Ratio — A Doodle with the Unit 11-Ball and Twenty Equatorial Cross-Polytopes

That the proton-to-electron mass ratio m_p/m_e ≈ 1836.15 can be approximated by 6π^5 = 1836.118 is a well-known numerical coincidence, dating from an extremely short 1951 note by F. Lenz. The present paper shows that 6π^5 need not be read as mere number-matching: it can be drawn,...

The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review

BACKGROUND: Cholangiolocarcinoma (CLC) is a rare liver cancer with ≥ 80% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial. We conducted a nationwide m...

Chimeric pseudomonad phasin enhances biosynthesis of short-medium-chain-length polyhydroxyalkanoates (PHAs) by Cupriavidus necator employing class II PHA synthase

Copolyesters of ( R )-3-hydroxybutyrate and medium-chain-length ( R )-3-hydroxyalkanoate) [P(3HB- co -mcl-3HA)] are a highly flexible kind of polyhydroxyalkanoates (PHAs), although the efficient biosynthesis still remains a challenge. Biosynthesis of P(3HB- co -mcl-3HA) copolyest...

Polymerization as a structuring strategy for hierarchical order and function

Abstract Polymerization has long been used as a tool for structural fixation: liquid or soft precursors are converted into solids. Recent advances in polymerization-based processing technologies have greatly expanded this role, now allowing complex external architectures to be in...