Institute of Molecular Biology, Academia Sinica

Structure-based identification and biological evaluation of a novel MAPKAPK2 inhibitor for pancreatic cancer

Pancreatic cancer remains a lethal malignancy with few effective treatment options. MAPKAPK2, a downstream effector of p38 signaling, represents a potential target for disrupting tumor survival pathways. Structure-guided computational screening has become an important strategy fo...

Coordinating Mesopore Geometry and Interfacial Water Dynamics for Iron‐Site Evolution in Nitrate Electroreduction

ABSTRACT Developing electrocatalysts with active sites that undergo structural evolution under operating conditions remains a challenge in electrochemical nitrate reduction. Here, we use single‐crystalline mesoporous metal–organic frameworks (MOFs) with distinct pore geometries t...

HOMEODOMAIN-LIKE shapes chromatin architecture and rewires leaf epidermal patterns

During development, cells balance proliferation and differentiation to generate diverse cell types, yet how these transitions are fine-tuned remains unclear. In the Arabidopsis leaf epidermis, stomata form through regulated cell division, whereas pavement cells and trichomes aris...