Institute for Basic Science

Transcriptome-based classification in mice with ASD-risk mutations

Autism spectrum disorder (ASD) is a neurodevelopmental condition with a strong genetic component. Large-scale human genetic studies have identified >1200 ASD-risk genes. We report a sex-balanced atlas of 1008 prefrontal RNA sequencing (RNA-seq) profiles from 17 mouse lines carryi...

Comparison of pectoralis major and serratus anterior activity during scapular protraction with and without reciprocal inhibition in healthy individuals

Background Sufficient scapular stability is essential for optimal upper-extremity function, with the serratus anterior (SA) playing a key role in both open and closed-chain exercises. However, compensatory pectoralis major (PM) overactivation often interferes with selective SA ac...

Tear-Based Dynamic Network Biomarkers for Pre-Disease Detection of Hyperuricemic Nephropathy via Smart Contact Lens

Abstract Early identification of the pre-disease state is critical for effective intervention and improved outcomes in chronic kidney disease. However, current diagnostic approaches mainly rely on serum-based biomarkers, which are limited in capturing dynamic physiological change...

Retrospective attention reveals a decaying theta rhythm in conscious access to a preceding stimulus

Conscious perception is often presumed to arise immediately upon external stimulation. However, retroperception—conscious access to a stimulus after it has disappeared—challenges this perspective by demonstrating temporally flexible awareness. The fine-grained temporal dynamics g...

WDR23 prevents bone loss by promoting autophagic degradation of TRAF6 in osteoclastogenesis

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a pivotal adaptor molecule in the receptor activator of nuclear factor-κB (RANK) and its ligand (RANKL) signaling pathways, which are essential for osteoclastogenesis. In this study, we identified WD40 repeat-containin...

Deterministic Switching‐Path Engineering of CMOS‐Integrated 2D Memristors for Neuromorphic Computing

ABSTRACT Two‐dimensional (2D) memristors are promising for low‐power and high‐speed neuromorphic hardware. However, their performance under circuit‐level constraints remains limited because resistive switching relies on native defects, hindering precise control of filament format...

Beyond Metallic Electrodes: Semiconductor Photoelectrocatalysis for Organic Synthesis

Abstract Photoelectrocatalytic (PEC) systems convert incident light into photovoltage, enabling reactions to proceed at significantly reduced overpotentials. Leveraging this inherent energy efficiency, recent efforts have rapidly expanded PEC applications beyond traditional energ...

Spectrally Programmable Spin‐Polarized Photocurrents in WSe 2 –NiPS 3 Magnetic van der Waals Heterostructures

ABSTRACT Efficient generation and control of spin‐polarized currents in semiconductors remain central challenges for spin‐based electronics, particularly due to impedance mismatch and the reliance on magnetic fields or ferromagnetic contacts. Here, we introduce a materials platfo...

Gate Metal‐Driven Sensing and Memory Bifunctionality in Intrinsically Stretchable Organic Electrochemical Transistors for Soft Neuromorphic Systems

ABSTRACT Intrinsically stretchable devices capable of integrating sensing, memory and signal processing are highly desirable for conformal bioelectronics. However, achieving such multifunctionality remains challenging due to conflicting operational requirements and the lack of me...

Censoring balancing functions for weighted log-rank tests

Censoring is a common feature of survival data. Weighted log-rank tests are widely used to compare survival curves representing different treatments under study, but their performance is often negatively affected by censoring. In this work, censoring balancing functions (CBFs) ar...

Intestinal fructose catabolism promotes obesity and insulin resistance via ileal lacteal remodeling

High-fructose corn syrup (HFCS) consumption is a risk factor for obesity and diabetes, yet the underlying mechanisms, especially at the specific organ level, are incompletely understood. Catabolism of dietary fructose primarily occurs in the small intestine and liver, with fructo...

Curvature-assisted dynamical compactification in a pre-inflationary higher-dimensional universe

A bstract We investigate a pre-inflationary dynamical compactification scenario in which a higher-dimensional expanding universe evolves into an effectively four-dimensional one through curvature-assisted modulus trapping. To obtain a calculable semiclassical realization, we cons...

Multiplicative irreducibility of shifted multiplicative subgroups

Abstract In a recent breakthrough, Kalmynin resolved conjectures of Lev–Sonn and Sárközy on additive decompositions of multiplicative subgroups of prime fields. In this paper, inspired by a related conjecture of Sárközy, we prove multiplicative analogues of Kalmynin's results. We...

Molecular filming: A director's grammar for visualizing chemistry in motion

Abstract Time‐resolved x‐ray and electron scattering now follow the changing structures of molecules directly, on femtosecond timescales and sub‐ångström length scales. The community has long captured this achievement in one evocative phrase: the molecular movie. Yet that phrase...

Influence of many-body correlation and mixed-valence fluctuations on X-ray magnetic circular dichroism and resonant inelastic X-ray scattering spectra

X-ray magnetic circular dichroism (XMCD) and resonant inelastic X-ray scattering with magnetic circular dichroism (RIXS-MCD) provide unparalleled insights into the electronic and magnetic dynamics of complex materials. However, interpreting their spectra in mixed-valence systems...

On the Order of Intersecting Hypergraphs

Abstract. Determining the maximum number of edges in an intersecting hypergraph on a fixed ground set under additional constraints is one of the central topics in extremal combinatorics. In contrast, there are few results on analogous problems concerning the maximum order of such...

Diffusion-weighted chemical exchange saturation transfer MRI in the human brain at 7T

Metabolite diffusion provides information on unique intracellular environments that are not captured by water diffusion. Conventional diffusion-weighted magnetic resonance spectroscopy (DW-MRS) is a useful tool for probing metabolite diffusion, but lacks spatial information. In t...

An autoinflammatory CDC42 variant M45L demonstrates the mechanism of pyrin inflammasome activation

CDC42 is an evolutionarily conserved guanosine triphosphatase (GTPase) regulating critical cellular and immune processes. Variants in CDC42 therefore cause a spectrum of developmental phenotypes, including hematological and immunological symptoms. Here, we identify a previously u...