Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Molecular mechanisms of supercritical CO2-induced interfacial softening in curcumin polymorphs

Unique properties of supercritical CO 2 (scCO 2 ) make it one of the most interesting “green” solvents for pharmaceutical particle formation and polymorph engineering. However, due to the complexity of the scCO 2 dynamics, the molecular mechanisms by which scCO 2 alters the stabi...

Lifetime exposure to atypical working hours among healthcare professionals compared with the workforce in other sectors: Nationwide cohort study

Background Despite well-documented health risks, cumulative exposure to atypical working hours (AWH) over a career remains poorly quantified, especially among healthcare workers. Objectives This study aimed to compare career-long AWH exposure among healthcare professionals and ot...

Dietary prevention of undernutrition reduces intestinal inflammation associated with an anti-inflammatory profile of gut microbiota in a preclinical model

Patients with inflammatory bowel diseases (IBD) have a high-risk for undernutrition. Undernutrition is associated with higher complications such as an increased mortality rate, a higher disease activity and an impaired quality of life in IBD patients. The aim of this study was to...

Learning-Based Methods and the Future of Numerical Ocean and Sea-Ice Modeling

The field of operational oceanography is undergoing a significant evolution with the increasing integration of artificial intelligence (AI) methods, which are complementing and, in some cases, redefining traditional numerical modeling approaches. This review explores how AI metho...

When Participation Becomes a Criterion: Developing an Analytical Framework for Participatory Science

Participatory science projects have multiplied in recent years, yet frameworks to analyse and evaluate them remain fragmented. While conventional research relies on standardized criteria, participatory research requires approaches that account for collaborative processes, governa...

Paler within the city: Carotenoid‐based colouration covaries negatively with the proportion of impervious surface in great tit ( Parus major ) territories across Europe

Urbanisation alters resource availability and exposes wildlife to novel environmental stressors, potentially driving phenotypic divergence. Carotenoid-based plumage colouration is a condition-dependent trait linked to dietary carotenoid acquisition and physiological allocation tr...

Deciphering the genomic signatures of climate vulnerability across 77 sheep breeds

Abstract Among domesticated species, sheep ( Ovis aries ) have achieved a wide geographic distribution due to their mobility, rusticity and ability to adapt to diverse environments and climatic conditions. Here, we characterise the genome-wide diversity of >1,000 sheep representi...

Sugar metabolism drives shoot branching by repressing BRC1 through miR319 –targeted TCP4 in Rosa

Abstract The coupling between sugar availability and shoot branching is well established, yet the underlying molecular mechanisms remain largely unknown. Here, using genome-wide profiling, we characterized the sugar signalling pathways by identifying 10 microRNAs (miRNAs) repress...

Computer-Aided Entrainer Design for Extractive Distillation Using Infinitely Sharp Splits

Abstract We present an integrated product-process design framework for ranking heavy entrainer candidates for minimum-boiling azeotrope separation, corresponding to the Serafimov class (1.0-1a), the most common such case. The framework combines computer-aided molecular design (CA...

Net carbon losses in Central African forests revealed by high-resolution biomass change maps

Dense humid forests in Central Africa hold vast biomass carbon stocks but are increasingly affected by small-scale disturbances that are difficult to detect with current satellite observations. Here, we generate 10 m canopy height maps for 2019–2022 using deep learning with space...

Splenic regulation of systemic platelet activation state

Platelets are essential to prevent blood loss and to orchestrate inflammation. Thrombotic complications of vascular disease and hyperresponsive platelets are associated with adverse outcomes, yet physiological mechanisms counteracting systemic platelet activation are poorly defin...

The crosstalk of autophagy and metabolism in plants

Autophagy in plants promotes cellular longevity and nutrient recycling by degrading unwanted organelles and damaged cytoplasmic components. This process is essential for plant stress tolerance and nutrient management. In all plant organs, autophagy plays a critical role in mainta...

Lactic acid bacterium F. sanfranciscensis impairs fitness of yeast M. humilis in a synthetic wheat sourdough medium

ABSTRACT Sourdough starters contain simple microbial communities, typically consisting of a few bacterial species and one or two yeast species. The yeast Maudiozyma humilis and the lactic acid bacterium Fructilactobacillus sanfranciscensis often co-occur in sourdough starters and...

The NPIS model: a consensus-based framework for evaluating non-pharmacological interventions

The term non-pharmacological intervention (NPI) refers to health prevention and care protocols supervised by healthcare professionals. However, no precise and widely adopted definition currently exists. Additionally, unlike drugs, NPIs do not have a global evaluation framework be...

Monoclonal anti-dsRNA antibody-based metagenomics (MADAM) reveal Pyricularia oryzae mycovirome

This study introduces MADAM (Monoclonal Anti-dsRNA Antibody-Based Metagenomics), a novel approach that integrates multiple technical modules previously used independently in other protocols. MADAM combines monoclonal antibody-mediated double-stranded RNA (dsRNA) enrichment, seque...

Unravelling the impact of nitrogen deprivation on the morphology and nanomechanical properties of Parachlorella kessleri

Abstract Nitrogen deprivation is commonly applied to enhance lipid accumulation in microalgae for third-generation biofuel production. However, its influence on cell wall morphology and nanomechanical properties, which critically affect downstream processing, remains poorly explo...

Quantifying the direct and indirect costs of reproduction

The energetic costs of reproduction remain incompletely resolved, despite being fundamental to life history theory. Recent work has drawn attention to indirect costs of reproduction and suggested that they may be underestimated in energy budget models. However, a challenge in the...

Distinguishing plant biophysical stress responses from temporal variability using vis–NIR spectroscopy

Visible–near infrared (Vis—NIR) spectroscopy is widely used for non-destructive plant monitoring; however, in time-series experiments, signals of interest are frequently masked by diurnal rhythms and systematic measurement drift. This limits the ability to clearly detect plant re...

Biodegradability test on a corn starch based compostable plastic bag: impact of moisture on CO2 emissions, microbial communities, and enzymatic activities

Compostable plastics are often considered as a solution for minimizing plastic contamination due to their biodegradation capacity in composting processes. However, the standards evaluating their biodegradability do not encompass the variability of uncontrolled composting systems,...

Climatology and trends of extreme precipitation in France: evaluation of an explicit-convection regional climate model

Climate change is intensifying the global water cycle, with extreme precipitation events increasing in frequency and intensity at the global scale. While trends in daily precipitation extremes are well-documented, sub-daily extremes – critical for flash flood risk – remain poorly...