Innsbruck Medical University

Chimeric Antigen Receptor T‐Cell Therapy in T Cell/Histiocyte‐Rich Large B‐Cell Lymphoma: A Systematic Review and Meta‐Analysis

T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare subtype of B-cell non-Hodgkin lymphoma with an aggressive clinical course and poor prognosis in the case of relapsed or refractory (r/r) disease. Recently, anti-CD19 chimeric antigen-receptor (CAR) T-cell therapy ha...

A single transcriptional regulator is crucial for the adaptation of Staphylococcus aureus to diverse niches

Adaptation of bacterial pathogens to new hosts often involves the exchange of mobile genetic elements, or generally the highly variable accessory genome. However, adaptation to different niches is often plastic, mediated by conserved pathways in the core genome. The general stres...

Intermittent hypoxia interventions for inducing ventilatory acclimatization to high altitude?

Accumulation of ∼200 h of hypoxia exposure (pre-acclimatization) has been suggested to prevent the development of acute mountain sickness when a person is subsequently exposed to high altitude. These pre-exposures are typically undertaken intermittently at or near the place of re...

Macrophage-specific LAMTOR2 deletion disrupts systemic iron homeostasis in mice

At the center of iron homeostasis, macrophages play a crucial role by phagocytosing senescent erythrocytes while nursing erythrocyte progenitors. A major route of cellular iron acquisition occurs via transferrin receptor 1 (TFR1)-mediated endocytosis of transferrin-bound iron, a...

Protocol for isolation and cryopreservation of human peripheral blood mononuclear cells for high-resolution respirometry

High-resolution respirometry (HRR) of peripheral blood mononuclear cells (PBMCs) relies on controlled preanalytical procedures. Here, we present an optimized workflow for PBMC isolation from human whole blood, followed by short-term cryopreservation at −80°C. The protocol include...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Clinical management of metachromatic leukodystrophy cases identified in the German and Austrian Newborn screening pilots

Abstract Background Metachromatic leukodystrophy (MLD) is a rapidly progressive leukodystrophy that leads to severe disability and early death if untreated. Autologous hematopoietic stem and progenitor cell gene therapy (HSPC-GT, atidarsagene autotemcel, arsa-cel) for early onset...

A DNA methylation–based risk score improves prognostic stratification in myelodysplastic neoplasms

Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and variable risk of progression to acute myeloid leukemia (AML). Although mutational data are already implemented into the most recent MDS risk models, (i.e...

Chikungunya virus uses the tetraspanins CD63, CD9, and CD151 to replicate in human synovial fibroblasts

The arthritogenic alphavirus chikungunya virus (CHIKV) causes debilitating long-lasting joint pain. Host factors used by CHIKV to infect joint cells are largely unknown. Here, we evaluated the role of the 19 tetraspanins expressed in primary human synovial fibroblasts in virus in...

The German S3-level guideline for the diagnosis and management of rare dental disorders

Abstract Objectives The aim of this German S3-level guideline project was to develop evidence-based recommendations to support professionals in the diagnosis and management of individuals with rare dental disorders. The research question was which form of dental care should be pa...

Nanopore long-read sequencing facilitates accurate diagnosis of KMT2B-related dystonia

Abstract Diagnosis of KMT2B -related dystonia remains challenging due to the high prevalence of variants of uncertain significance and technological constraint of short-read pipelines. To overcome these limitations, we integrated nanopore-based long-read sequencing with a validat...

Entrustable professional activities for medical students and graduates of Austrian medical universities

Summary Background Entrustable professional activities (EPAs) translate competency-based medical education into observable clinical work and can clarify expectations at the undergraduate-postgraduate transition. In Austria, undergraduate EPA implementation has been heterogeneous,...

Impedance-based tracking of a cochlear implant electrode reliably detects successful array insertion

Abstract Introduction Continuous impedance measurements during cochlear implantation have been hypothesized to provide a reliable indication if the electrode is inside or outside the cochlea. Therefore they provide a valuable feedback mechanism for successful insertion to the sur...

Biliary complications in pediatric living donor liver transplantation: An international multicenter analysis of risk and prognostic factors

Biliary reconstruction is often considered the Achilles’ heel of liver transplantation, yet risk factors and outcomes remain poorly defined, particularly in pediatric living donor liver transplantation (LDLT). This international multicenter study aims to identify predictors of bi...

From Iodine Maps to Brain Window Images: Quantitative Visibility Thresholds of Iodine Staining Using Photon-Counting CT—A Retrospective Observational Study

Objectives: We aimed to determine quantitative photon-counting CT (PCCT)-derived iodine map (IM) attenuation associated with visual detectability of parenchymal hyperattenuation on conventional brain window (BW) images after mechanical thrombectomy (MT) and to assess correspondin...

Intensive lipid lowering therapies improve LDL-C goal achievement, but does high Lp(a) remain a barrier?

Abstract Background LDL-C goal achievement is suboptimal in patients undergoing coronary artery bypass grafting (CABG). We aimed to find factors associated with LDL-C goal achievement in patients under stable lipid-lowering therapy (LLT) at admission for CABG. Methods A prospecti...

Results from the Pan-European CIEMAR study: Local Tumour Control After Microwave Ablation of Colorectal Liver Metastases and Exploratory Associations with Ablation Margins and Confirmation Software

Abstract Purpose The CIRSE Emprint Microwave Ablation (MWA) Registry (CIEMAR) was designed to evaluate real-world effectiveness of MWA for colorectal liver metastases (CRLM). This analysis reports on local tumour control and includes post-hoc analyses of ablation margin size and...

Large-scale genome analysis of Listeria monocytogenes from Austrian food producers reveals differences in accessory genome dynamics and phage integration in persistent genomes

Abstract Background As the causative agent of listeriosis, Listeria ( L .) monocytogenes is an important food safety hazard and public health concern. The ability of some L. monocytogenes strains to establish in food processing environments poses the threat of contamination to fo...

PSMA PET/CT-guided salvage elective nodal radiotherapy for nodal metastases after radical prostatectomy: a bi-institutional long-term outcome analysis

PURPOSE: PSMA PET/CT has transformed the detection of nodal recurrence after radical prostatectomy, yet real-world evidence on long-term outcomes of PSMA PET/CT-guided salvage elective nodal radiotherapy (ENRT) remains limited. This study evaluated oncological outcomes of PSMA PE...

Exploration of structural optic nerve changes in mouse models of retinal and neuronal degeneration with optical coherence tomography

Abstract Purpose The optic nerve head (ONH) is a central feature of the retina, affected in many human ocular pathologies, yet it has remained underexplored in most mouse models of disease. We hypothesize that the analysis of the ONH can yield valuable insight into the phenotype...