Indiana University – Purdue University Indianapolis

Clinical evaluation of porcelain‐veneered zirconia crowns with 3D‐printed textured cores: A preliminary randomized clinical trial

Abstract Purpose Porcelain‐veneered zirconia crowns (PVZCs) provide the opacity required to mask discolored substrates and translucency needed for a natural appearance. Although in vitro studies have demonstrated that three‑dimensionally (3D)‑printed textures on zirconia cores ca...

Lymphatic Preconditioning for Preservation of Lymphatic Function

Lymphedema is chronic swelling from lymphatic dysfunction. The vascular delay phenomenon is used in flap reconstruction to increase flap viability through staged selective partial disruption of blood supply to enhance flap survival, followed by flap transfer 7–10 days later. A si...

Hemispheric Asymmetry of Neuroimaging Biomarkers in Early Onset Alzheimer's Disease: Clinical and Cognitive Outcomes

Objective Individuals diagnosed with Alzheimer's disease (AD) often exhibit amyloid, tau, and atrophy predominantly in the left or right hemisphere, but group‐level analyses typically ignore inter‐individual variability and changing asymmetry patterns when averaging data across p...

Photon Absorption Remote Sensing Virtual Histopathology: A Preliminary Exploration of Diagnostic Equivalence to Gold-Standard H&E Staining in Skin Cancer Excisional Biopsies

Background: Photon Absorption Remote Sensing (PARS) enables label-free imaging of subcellular morphology by observing absorption interactions. Coupled with deep-learning, PARS produces label-free virtual hematoxylin and eosin (H&E) images in unprocessed tissues. This study evalua...

Clinical Ethics Framework for Last‐Minute Pediatric Refusal of Anesthesia Induction

Induction of anesthesia is one of the most distressing moments for pediatric patients during their perioperative experience. They may consequently refuse induction at the last minute. Anesthesia providers are then placed in a challenging ethical dilemma: they must seek to gain th...

Analysis of macular ganglion cell status in dry AMD using single-nucleus transcriptomics

Age-related macular degeneration (AMD) is classically defined by photoreceptor and retinal pigment epithelium degeneration; however, increasing evidence suggests that retinal ganglion cells (RGCs) may also be affected. The RGCs, including intrinsically photosensitive RGCs (ipRGCs...

Trends in Ophthalmic Hospital Transfers and Consultations Across US Academic Centers

Importance Academic medical centers increasingly serve as a safety net for urgent and complex ophthalmic conditions, yet trends in the demand for hospital-based ophthalmic services remain poorly characterized. Objective To characterize multi-institutional trends in ophthalmology...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

HIV and Antiretroviral Therapy Influence Tumor Microenvironment Architecture, Subclonal Evolution, and Immune Evasion Strategies in Diffuse Large B-Cell Lymphoma

The tumor immune microenvironment (TIME) and tumor heterogeneity shape prognosis and therapeutic response in Diffuse Large B-cell Lymphoma (DLBCL), but HIV-associated (HIV+) DLBCL remains poorly understood. To characterize the TIME and tumor-intrinsic features of DLBCL across a s...

Paying for Pain: How Healthcare Costs Influence Physical Pain Predictions

ABSTRACT As healthcare costs continue to rise in the United States, consumers increasingly encounter financial burdens that impact their economic well‐being along with their psychological experiences surrounding medical care. This research examines how the pain of paying, a well‐...

PD GENEration: an international Parkinson’s disease genetic research study

Abstract Background PD GENEration (NCT04057794, NCT04994015), sponsored by the Parkinson's Foundation in partnership with Aligning Science Across Parkinson’s (ASAP) through the Global Parkinson’s Genetics Program (GP2), is an international, observational, clinical research study...

Ligand-Shell Softness Directs Symmetry Transitions in Nanotripod Superstructures

Abstract Low-symmetry, nonconvex nanocrystals offer access to superlattices with structural motifs that are difficult to realize from convex building blocks. Here, we show that polymer-grafted Gd2O3 nanotripods assemble into compact achiral and open chiral nanoporous superstructu...

Modifiable Factors Associated With Substance Use Disorder Screening by Nurses: A Cross‐Sectional Survey

ABSTRACT Aim To identify the training, organizational, attitudinal and competence factors associated with how frequently nurses screen patients for substance use disorder, and to determine which remain associated after demographic and structural characteristics are taken into acc...

Generating the symmetric group by three prefix reversals

The cubic pancake graphs are Cayley graphs over the symmetric group $\mathrm{Sym}_n$ generated by three prefix reversals. There is the following open problem: characterize all the sets of three prefix reversals that generate $\mathrm{Sym}_n$. As the largest prefix reversal of len...

Variations in diagnosis and management of hemodynamically significant patent ductus arteriosus across neonatal intensive care units in the Children’s Hospitals Neonatal Consortium

Abstract Objective Collate patent ductus arteriosus (PDA) guidelines among Children’s Hospitals Neonatal Consortium (CHNC) centers and identify variations in the diagnosis and management of hemodynamically significant PDA (hsPDA). Study Design: A descriptive survey requesting wri...

Journeys of Parents with LGBTQ+ Children: How Trauma and Healing Reshape Identity and (Mis)Informating Practices

This study examines how parents of LGBTQ+ individuals in South Korea navigate the emotional rupture fueled by fear, isolation, and disorientation after learning their children’s queer identity, encounter queer-related (mis)information as a way of coping with this emotional toll,...

Inducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes

Nicotinamide adenine dinucleotide (NAD) is a metabolic cofactor regulating energy metabolism, epigenetics, DNA repair, and signaling. Although NAD declines with vitamin B3 deficiency, disease, and aging, systemic consequences of chronic depletion remain unclear. Here, we characte...

Global Paid and Unpaid Productivity Losses Due to Gastrointestinal Cancer Mortality

OBJECTIVES: Gastrointestinal (GI) cancers contribute substantially to premature mortality, yet their full economic burden, including unpaid work, remains underquantified. We aimed to estimate global productivity losses attributable to GI cancer mortality, considering paid and unp...

The Double-Edged Power of Mentors: How Daily Feelings of Power Shape Mentees’ Experiences of Gender- and Race-Based Harm and Support

Abstract Power asymmetries shape everyday mistreatment in workplaces and academic training settings, yet little is known about how mentors' momentary feelings of power affect mentees' daily gender- and race-based experiences in real time. Drawing on power-approach and power-ampli...

Promoting Optimal Pediatric Readiness at US Trauma Centers: Understanding and Addressing Barriers

Children treated at facilities prepared to provide emergency pediatric care have improved outcomes, but access to pediatric-ready care remains inconsistent. A multidisciplinary spotlight session at the 2026 American College of Surgeons Committee on Trauma Annual Meeting examined...