Institution
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
Recent research
- Biology
Glycome remodeling programs pathogenic γδ T17 cell responses in autoimmunity
Glycans play fundamental roles in T cell biology; however, the glycome landscape of γδ T cells remains to be unlocked. Despite the growing importance of γδ T cells in host defense, tissue homeostasis, and diseases, the glycosylation mechanisms guiding their activation, commitment...
- BiologyOpen access
Natural History of Rare Tumor Risk Syndromes: A Scoping Review to Inform Cost-Effectiveness Models
Background Hereditary cancer syndromes account for approximately 10% of all cancers. Many of these, classified as rare tumor risk syndromes (RTRS), lack comprehensive data on natural history, lifetime cancer risk, and the long-term impact of surveillance. These evidence gaps limi...
- Health & MedicineOpen access
Gamma irradiation offers a simple and reagent-free strategy for tailoring the physicochemical properties of starch for the development of functional biomaterials, although its application in protein delivery systems remains largely unexplored. In this study, starch was irradiated...
- Health & MedicineOpen access
Sex and Mortality Among Patients with Papillary Thyroid Cancer
Importance Unlike patient age, which has been a well-established and routinely used primary biological prognostic factor in the risk stratification of papillary thyroid cancer (PTC), the prognostic value of patient sex remains controversial in this common endocrine malignant neop...
- Health & MedicineOpen access
Chaperone-inspired nanobodies enable pathway-selective control of Tau self-assembly
Abstract Selective control of pathogenic protein self-assembly remains a major challenge for intrinsically disordered amyloid-forming proteins such as Tau. Here we show that nanobodies originally raised against the chaperone S100B unexpectedly cross-react with Tau as potential pa...
- Health & MedicineOpen access
Abstract Background Non-small cell lung cancer (NSCLC) accounts for ~ 85% of lung cancers and is associated with poor outcomes in advanced stages. Radiotherapy (RT) is central to NSCLC treatment, yet locoregional relapse remains frequent. Increasing evidence indicates that, beyon...
- Society & EconomicsOpen access
Talent identification and development in soccer is a multifaceted process that requires the evaluation of players across a range of attributes. This study compared the perspectives of Portuguese coaches and scouts regarding scouting practices and examined their observation and ev...
- Health & Medicine
Established disease-centered prognostic systems may be less tailored to elderly/non-transplant-eligible (NTE) patients with multiple myeloma (MM), in whom host-related factors such as age, performance status, and renal function strongly influence all-cause outcomes. We developed...
- BiologyOpen access
Targeted therapies have substantially advanced cancer treatment; however, therapeutic resistance remains a major challenge, particularly in lung cancer. Polo-like kinase 1 (PLK-1), a key regulator of mitosis, is frequently overexpressed in lung tumors and has emerged as an attrac...
- Health & MedicineOpen access
Adverse Childhood Experiences (ACE) are associated with poor health outcomes, but their effect on the medication adherence of patients with type 2 diabetes (T2DM) remains unclear. This study aimed to assess the relation between ACE and medication adherence, while also exploring w...
- BiologyOpen access
Abstract Postsynaptic scaffolding protein SAP90/PSD95-associated protein 3 (SAPAP3) modulates cortico-striatal signalling and regulates the maintenance of synaptic structure. Notably, SAPAP3 defects have been reported in several human psychiatric disorders that share pathophysiol...
- Climate & EnvironmentOpen access
Geospatial assessment of agrivoltaic feasibility in the Iberian Peninsula
This work investigates the feasibility of deploying agrivoltaic (AgriPV) systems in the Iberian Peninsula through an integrated geospatial assessment framework. The proposed methodology combines geospatial screening, agroclimatic and spatial datasets, crop suitability assessment,...