i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto

Preclinical Evaluation of Combined Polo-like Kinase 1 Inhibition and Navitoclax in Experimental Models of Lung Cancer

Targeted therapies have substantially advanced cancer treatment; however, therapeutic resistance remains a major challenge, particularly in lung cancer. Polo-like kinase 1 (PLK-1), a key regulator of mitosis, is frequently overexpressed in lung tumors and has emerged as an attrac...

Exploring the relation between childhood adversity and diabetes medication adherence: a cross-sectional study

Adverse Childhood Experiences (ACE) are associated with poor health outcomes, but their effect on the medication adherence of patients with type 2 diabetes (T2DM) remains unclear. This study aimed to assess the relation between ACE and medication adherence, while also exploring w...

The postsynaptic scaffolding protein SAPAP3 shapes mitochondrial activity: the case of Huntington’s disease

Abstract Postsynaptic scaffolding protein SAP90/PSD95-associated protein 3 (SAPAP3) modulates cortico-striatal signalling and regulates the maintenance of synaptic structure. Notably, SAPAP3 defects have been reported in several human psychiatric disorders that share pathophysiol...

Geospatial assessment of agrivoltaic feasibility in the Iberian Peninsula

This work investigates the feasibility of deploying agrivoltaic (AgriPV) systems in the Iberian Peninsula through an integrated geospatial assessment framework. The proposed methodology combines geospatial screening, agroclimatic and spatial datasets, crop suitability assessment,...