Hunan University

Logic‐Gated DNA Cascade Amplification Enables High‐Fidelity Intercellular Communication in Synthetic Protocells

ABSTRACT Intercellular communication in synthetic protocells is often constrained by passive diffusion, leading to signal attenuation and spurious activation that limit functional outcomes. Here, we report a programmable communication framework that integrates logic‐gated DNA sig...

Logic‐Gated DNA Cascade Amplification Enables High‐Fidelity Intercellular Communication in Synthetic Protocells

ABSTRACT Intercellular communication in synthetic protocells is often constrained by passive diffusion, leading to signal attenuation and spurious activation that limit functional outcomes. Here, we report a programmable communication framework that integrates logic‐gated DNA sig...

Neural processing of speech envelopes from different languages and post-stimulation functional connectivity in newborns: an fNIRS study

Speech envelopes convey low-frequency temporal structure, including speech rhythm and prosody, and provide important cues for early speech processing in newborns. However, how the newborn brain processes speech envelopes and how brief exposure to them affects post-stimulation neu...

Archaeometallurgical Study of Middle to Late Western Han (c.140 BC – AD 8) Bronze Artifacts from Western Hunan, China

ABSTRACT Based on typology of cultural attributes, the present study classifies the middle to late Western Han period 21 bronze objects from western Hunan into two categories: objects with indigenous characteristics, and with Central Plains characteristics. The analytical results...

Research Progress on Small-Molecule Inhibitors Targeting Salt-Induced Kinases

Abstract As prominent members of the AMPK family, salt-induced kinases (SIKs) play pivotal roles in regulating cellular metabolism, immune responses, and the tumor microenvironment. Aberrant SIK expression is closely linked to oncogenesis, metabolic disorders, and inflammatory di...

Self-Aligned AlO x Spacer Enabling 10 nm-Scaled InZnSnO Thin-Film Transistors for 2T0C DRAM

Abstract Oxide semiconductors are promising for low-power dynamic random access memory (DRAM) due to their ultralow off-state leakage and back-end-of-line compatibility. Continued transistor scaling is essential to further enhance electrical performances, however, conventional li...

Annealing‐Induced Crystalline Reconstruction and Toughening Mechanisms in β‐Nucleated Long Glass Fiber‐Reinforced Polypropylene Random Copolymer

ABSTRACT Long glass fiber‐reinforced modified polypropylene random copolymer (LPM) systems are widely applied in lightweight structural components. However, rapid injection molding induces heterogeneous crystallization, limiting mechanical performance. Moreover, the intrinsic bri...

Integrated multi-omics decodes the AKI-to-CKD transition: from ensemble discovery to structure-guided translational targeting

The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) constitutes a major global health burden. Identifying causal drivers remains challenging due to proteomic complexity and confounding biases. We aimed to construct a discovery framework to identify actio...

Controllable multiple optical bottles of the circular Airy Swallowtail beam

Although optical bottles have received considerable attention, research on the precise manipulation of multiple-optical-bottle structures has remained relatively limited. In this paper, we innovatively propose a composite circular Airy Swallowtail beam (CASB). Compared with other...

Empathy, logophoricity and the nature of Chinese long-distance reflexive ziji

Abstract In this paper, we explore an explanatory theory for the Long-Distance Reflexive (LDR) ziji in Chinese from the semantic-pragmatic perspective. Although it is generally held that LDR ziji has the properties of de se interpretation, subject-orientation and the blocking eff...

Beyond In Vitro Brightness: A Matched-Probe Study of Chemiluminescence Contrast for In Vivo Peroxynitrite Imaging

Probe selection for in vivo chemiluminescence imaging commonly relies on intensity and tissue-overlay measurements performed in vitro, yet these measurements do not reproduce the activation background, probe distribution, and optical environment of a living animal. Here, we test...

Dual role of Al2Y phase for heterogeneous microstructure and strength–plasticity synergy in Mg-Y-Al alloys via continuous squeeze casting-extrusion

In this paper, the effects of the content and morphology of Al 2 Y phase on the microstructures and mechanical properties of Mg-1.5nY-nAl ( n = 0.5, 1.0, 1.5, 2.0) alloys fabricated by continuous squeeze casting-extrusion(CSCE) process are investigated. The increase in the conten...

Achieving breakthrough high strength in AZ31 magnesium alloy bar via a novel single-pass extrusion process

AZ31 magnesium alloy generally suffers from insufficient room-temperature strength. Meanwhile, conventional processing routes offer limited strengthening efficiency, and severe plastic deformation (SPD) processes face difficulties in industrial upscaling. To address these bottlen...

Exploring the Role of AI-Supported Motor-Skill Language Learning Tools in EFL Learners’ Willingness to Communicate: The Mediating Roles of Grit and Enjoyment

It is widely known that artificial intelligence (AI) offers creative opportunities for enhancing English language students’ performance. Nevertheless, there is little information regarding the effect of AI-based tools on students’ willingness to communicate (WTC). In addition, em...

Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer

Extrachromosomal DNA (ecDNA) has emerged as a major contributor to cancer aggressiveness, yet its role extends far beyond its classical definition as a vehicle for oncogene amplification. Recent studies indicate that ecDNA functions as a dynamic regulatory platform that reshapes...

A coordinated control strategy for GFL-ES and GFM-ES to enhance PFR performance of interconnected and disconnected power systems

At present, grid-following energy storage (GFL-ES) and grid-forming energy storage (GFM-ES) have been extensively deployed in power systems, both of which exhibit distinct operational characteristics in primary frequency regulation (PFR). However, their independent participation...

High-dimensional claim severity modeling with misrepresentation adjustment via deep learning

Abstract In insurance underwriting, applicants may deliberately misrepresent certain risk factors to secure lower premiums. However, from the insurer’s perspective, verifying the true status of these risk factors is both time-consuming and resource-intensive. To address this chal...

Alignment response time for non-spherical particles in turbulence

Evolution of spheroidal particle orientation in turbulence is a fundamental problem in particle-laden flows. In this study, we introduce a response time for the spheroidal particle orientation in turbulence, representing a time scale for the particle with different initial orient...

Spinopelvic alignment changes after unilateral total knee arthroplasty associated with functional recovery

Abstract Background The biomechanical interaction between knee pathology and spine–pelvis alignment in advanced knee osteoarthritis (KOA) has received increasing attention. This study evaluated short-term changes in spinopelvic alignment after unilateral total knee arthroplasty (...

Sub-diffraction far-field dark-field nanoscopy via low-index microlens and deep learning

Far-field imaging methods capable of resolving samples beyond the diffraction limit of light are essential for understanding the intricate details of molecular interactions in physical chemistry and biophysics. Here, we demonstrate the use of low-index microspheres to enhance the...