Hunan University

Discovery of Tricyclic Oxazinoquinolinone-Based BCL6 PROTAC Degraders with Potent Activity Against Diffuse Large B-Cell Lymphoma

Abstract B-cell lymphoma 6 (BCL6) is a key transcriptional repressor involved in the pathogenesis of diffuse large B-cell lymphoma (DLBCL). In this study, scaffold hopping of BI-3802 led to compound 1, a new tricyclic BCL6-targeting ligand. Further optimization of linker architec...

River Cooling Distances of the Xiang River in Hengyang: Spatiotemporal Evolution and Associated Factors Based on LCZ

Rapid urbanization has intensified the urban heat island (UHI) effect, yet the river cooling distance and its associated influencing factors remain poorly understood. We retrieved Land Surface Temperature (LST) from Landsat imagery and mapped Local Climate Zones (LCZs) using the...

Localized Patterns in the Gierer Meinhardt Model on a Cycle Graph

Abstract. In this study, we provide a detailed analysis of the spike solutions and their stability for the Gierer–Meinhardt model on discrete lattices. We explore several phenomena that have no analogs in the continuum limit. For example in the discrete case, the system retains s...

Frequency Security-Constrained Coordinated Optimal Configuration of Multi-Type Flexible Resources

With the large-scale integration of converter-based renewable energy sources replacing conventional units, the risks of power system supply–demand imbalance and post-contingency frequency instability have increased dramatically. Expanding the flexible resource portfolio and achie...

Durability of coastal RC envelopes in salt-spray environments: A study through integrated normalized phase-field and dynamic THMC modeling

The long-term performance of building envelopes in coastal regions is severely challenged by salt spray, humidity, and wind-driven rain, which accelerate chloride ingress, steel corrosion, and cracking in reinforced concrete (RC) structures. To accurately capture the coupled degr...

Existence of Strong and Ground State Solutions for a Class of Euclidean Bosonic Equations Involving a Composite Fractional Operator

ABSTRACT In this paper, we study nonlinear Euclidean equations involving the composite fractional pseudo‐differential operator , where , are positive parameters and stands for the identity operator on . We here look to the solvability of such equations. Thus, we first show that e...

Membrane-Anchored Dual-Targeting Aptamer Engagers for Programmable T Cell Redirection in Solid and Hematological Cancers

Abstract Inefficient immune synapse formation limits the therapeutic efficacy of T cell-based immunotherapy in both solid tumors and hematological malignancies. Here, we report a fully synthetic, membrane-anchored dual-targeting aptamer engager, AptE 2, that acts as a programmabl...

Drought memory and vegetation shifts triggered by recurrent extreme drought events in alpine peatlands amplify the sensitivity of carbon sink function to drought

Climate change is expected to intensify the frequency and severity of extreme drought events, profoundly influencing terrestrial ecosystem carbon budgets. Peatlands are crucial carbon reservoirs in the global carbon cycle, storing nearly one-third of the world's soil carbon. Howe...

RGU-AVS: Residual-Driven Gaussian Uncertainty for Pool-Based Active View Selection in 3D Gaussian Splatting

Pool-based active view selection seeks to identify an informative subset of training images from a pre-acquired image pool, thereby reducing redundant observations of 3D Gaussian Splatting (3DGS). Existing methods mainly estimate candidate-view utility from predictive uncertainty...

Citron kinase activity controls alternative splicing events that drive prostate cancer growth

Prostate cancer (CaP) remains a major cause of cancer death in men, underscoring the need for mechanistically novel therapies. We previously identified the action of the mitotic kinase citron (CIT) kinase as a key driver of CaP progression and promising therapeutic target, but se...

Eggshell-Templated Mn-Doped Hydroxyapatite Composite Scaffold: Coupling ROS Scavenging with Piezo1 Activation for Bone Regeneration

Abstract The treatment of critical-sized bone defects remains challenging due to immune microenvironment dysregulation characterized by excessive ROS, persistent inflammation, and apoptosis, which impede tissue regeneration. Conventional biomaterials often overlook the unique str...

Lattice-Oxygen-Mediated Electronic Reconstruction of High-Entropy Oxides for Durable Fenton-like Water Treatment

Abstract High-entropy catalysts offer broad compositional tunability for peroxymonosulfate (PMS)-based water treatment, yet achieving rapid, selective, and durable oxidation remains challenging because metallic bonding in high-entropy alloys (HEAs) limits electronic communication...

Ultra‐Sensitive, Decoupled Multimodal Sensing via Dual‐Network Iontronic Organohydrogels

ABSTRACT Flexible sensors capable of mimicking human skin's multimodal perception are highly desired for wearable electronics. However, achieving inherently decoupled detection of multiple physical stimuli in a single device remains a fundamental challenge. Here, a polyacrylamide...

Secondary Amine Chain Length Governs CO2 Absorption in DEEA-Based Blends: Screening, Equilibrium, Thermodynamic, and Speciation

Abstract The effect of secondary amine alkyl chain length on CO2 absorption was investigated in DEEA blends with MAE, EAE, and BAE. Rapid screening identified a 2.5:2.5 molar ratio as the representative formulation based on CO2 loading, saturation behavior, viscosity, and regener...

High‐Purity Hydrogen Production From Water–Gas Shift Reaction in a High‐Temperature Polymer Electrolyte Membrane Electrolyzer

ABSTRACT The water–gas shift reaction (WGSR) is a critical pathway for hydrogen production, yet current methods face trade‐offs between purity and scale. Thermocatalytic WGSR achieves high product purity but requires energy‐intensive gas separation, while room‐temperature electro...

Faithful Global Convergence for the Rescaled Consensus–Based Optimization

Abstract. We analyze the consensus-based optimization algorithm with a consensus point rescaled by a fixed parameter [Formula: see text]. Under minimal assumptions on the objective function and the initial data, we establish its unconditional convergence to the global minimizer....

Physics-constrained diffusion-based data augmentation for active sonar under low-SNR sea conditions

The limited availability of real sea-trial target echoes restricts the training of data-driven active sonar detection models. Simulated echoes can increase the sample size, but their distributions often differ from those of real ocean environments. To address this problem, this p...

DNA nanodevice-engineered macrophages as living sensors for dual-mode in vivo monitoring of tumor-associated macrophage polarization

Exploiting macrophages as cell-autonomous reporters of their polarization states represents a promising strategy for interrogating tumor-associated macrophage (TAM) phenotypes in cancer. Here, we develop a macrophage-based sensing platform, termed eMφ. This platform is created by...

Underwater image enhancement via boundary-aware gradient domain reconstruction and intuitionistic fuzzy set similarity measure-guided wavelet fusion for lowlight conditions

Due to the light absorption and scattering effects of water in dark underwater environments, along with the sensitivity limitations of imaging devices, captured images generally suffer from color distortion, low contrast, blurred details, and uneven illumination. These issues sev...

Pickering Emulsions with Long-Term Stability from Ultrafine Amphiphilic Benzyl-Modified Silica Nanoparticles

Abstract Pickering emulsions offer superior stability and eco-friendly properties across multiple industries due to solid particle stabilization at oil–water interfaces. However, the design and synthesis of ultrafine nanoparticles capable of stabilizing Pickering emulsions have a...