Hunan University

Multi-objective and cross-scale inverse design of temperature-control materials via physics-constrained machine learning

Abstract Temperature-control materials, notably composite phase-change materials (CPCMs), show great potential for the thermal management of next-generation power electronics. However, the synergistic optimization of multiple performance metrics still relies heavily on Edisonian...

Achieving simultaneous strength-ductility-corrosion optimization of solid-state additive friction stir deposited superlight Mg-Li alloy by a hybrid high flow rate Argon/CO₂ shielding atmosphere

High-performance Mg–Li alloys were fabricated via solid-state additive friction stir deposition under a mixed Ar/liquid CO₂ atmosphere, which addresses severe oxidation and unfavorable thermal cycling issues during additive manufacturing. Benefiting from optimized microstructures...

Global and regional brain-age gaps in primary trigeminal neuralgia: a cross-sectional structural MRI study of 133 anatomical structures

Primary trigeminal neuralgia (TN) is a severe craniofacial neuropathic pain disorder. Quantitative magnetic resonance imaging (MRI) studies suggest that TN-related alterations may extend beyond the trigeminal pathways. The brain-age gap (BAG) is MRI-predicted brain age minus chro...

A Fail-Safe Topology Optimization Method for Fiber-Reinforced Composite Structures Under Dynamic Loads

A fail-safe topology optimization method for fiber-reinforced composite structures under dynamic loads is proposed to achieve the concurrent optimization of structural topology and fiber orientations, as well as enhance the structural redundancy subject to damage cracks of fiber-...

Dimension-DependentPhotoinduced Oxygen Passivationin Tin-Based Perovskites

Abstract All-inorganic lead-free tin-based perovskites are ideal candidate materials for lead-based perovskites due to their environmentally friendly nature. However, their atmospheric instability remains a significant hurdle for practical applications. In this study, zero-dimens...

Inferring tumor dependency maps from histopathology through imputed transcriptomics

Gene dependency maps from cancer cell lines define context-specific essential genes, but comparable dependencies in tumors remain largely inaccessible. This gap limits the identification of actionable therapeutic vulnerabilities. Here we present a two-stage deep learning framewor...

Beyond Tool Rationality: Contextualizing AR Picture Book Acceptance in Parent–Child Shared Reading

Augmented reality (AR) picture books are increasingly used in family learning and parent–child shared reading, but their adoption within families remains underexplored. Based on 439 valid responses from Chinese families, structural equation modeling examined adoption determinants...

Shenfu Injection attenuates isoproterenol-induced heart failure partly through modulation of the TNF-α/TNFR1/NF-κB signaling pathway

Shenfu injection (SFI) is widely used for heart failure (HF), but its cardioprotective mechanism remains incompletely understood. In this study, an isoproterenol-induced HF rat model, H9c2 cell injury model, network pharmacology, GEO analysis, molecular docking, and molecular dyn...

Unsteady aerodynamics and underbody flow characteristics of high-speed trains with bogie covers at 400 km/h

Although high-speed train (HST) bogie covers effectively reduce aerodynamic drag, they raise safety concerns due to lift-induced oscillations caused by unsteady underbody flow. This study investigates the effects of various bogie covering structures on aerodynamic load pulsations...

Ni-Mediated RedoxEngineering Enabled In Situ Constructionof Oxygen Vacancies on MnO/C for Furfural Selective Hydrogenationin Ethanol

Abstract The selective hydrogenation of biomass-derived furfural (FF) to high-value furfuryl alcohol (FA) is critical for the sustainable production of furan-based chemicals. However, designing a catalyst that can selectively hydrogenate C═O bonds is still a huge challenge. Herei...

Reconciling strong coordination and anion-reinforced solvation structure enables nonflammable electrolytes for potassium-ion batteries

Nonflammable electrolytes are pivotal for improving the safety of potassium-ion batteries. However, their broad adoption has been hindered by the inadequate electrode compatibility of conventional nonflammable electrolytes, which typically result from strong solvation and excessi...

Bioactive PdPt nanosheets for hypoxia modulation-enhanced radiotherapy

With the global rise in cancer incidence, the development of effective and safe therapeutic strategies remains an urgent priority. Although radiotherapy (RT) is widely used in clinical oncology, its therapeutic efficacy is often compromised by the hypoxic tumor microenvironment,...

Multifunctional Diluent Enables High‐Voltage and Flame‐Retardant Potassium‐Ion Batteries

ABSTRACT Potassium‐ion batteries (PIBs) emerge as a highly promising candidate system in large‐scale energy storage, owing to their abundant resources, low cost, and potentially high operating voltage. However, the current development of PIBs still faces core bottlenecks such as...

A Real-Time Single Image Haze Removal Accelerator for Increasingly Automated Vehicles

Autonomous vehicles at L2 and above are increasingly relying on stereo vision systems, where haze removal is critical to detect obstacles hidden in fog. Existing image haze removal techniques have low processing speed and high resource consumption, restricting their application s...

In Situ Sodiation of CoSe 2 Modulating Charge Transfer in Sodium−Selenium Batteries

ABSTRACT Selenized polyacrylonitrile (SePAN), characterized by the unique C−Se covalent bonds, can suppress the formation of polyselenides and their associated shuttle effect in sodium−selenium (Na−Se) batteries. However, its polymeric structure and distinct conversion mechanism...

Flexible Membrane-IntegratedZipper CHA Amplificationfor Rapid and Sensitive MicroRNA Detection

Abstract Catalytic hairpin assembly (CHA) is a widely employed signal amplification strategy for developing highly sensitive DNA biosensors, holding great promise for early disease diagnosis. However, conventional CHA systems often suffer from slow reaction kinetics, high nonspec...

Peukert‐Informed Prediction and Screening of Manganese‐Based High‐Rate Potassium Cathode

ABSTRACT Manganese‐based layered oxides have emerged as promising cathode materials for potassium‐ion batteries owing to their low cost, environmental benignity, structural diversity, and high theoretical capacity, yet suffer from poor rate performance. Compositional regulation o...

Establishing the role of ZBTB20 mutations in GnRH deficiency and impaired neurogenesis in the subventricular zone: a human cohort and animal model study

Background Congenital hypogonadotropic hypogonadism (CHH) arises from defective development or dysfunction of GnRH neurons. Olfactory bulb (OB) malformations frequently accompany CHH, a condition termed Kallmann syndrome (KS). Nevertheless, approximately 50% of CHH cases remain g...

A Parallel‐Computing Based Topology Optimization Method of Bi‐Modulus Material Structures With Large Property Difference

ABSTRACT Engineering materials frequently exhibit considerable disparities between their tensile and compressive moduli. However, there are some difficulties in existing topology optimization methods for material structures with large disparities between their tensile and compres...