Hunan Normal University

Hypoxic Exercise Alleviates Diabetic Skeletal Myopathy in Zebrafish in Association with Hif1a/Foxo3a Signaling and Mitochondrial Quality Control

Type 2 diabetes mellitus (T2DM) is characterized by skeletal muscle insulin resistance, which contributes to systemic metabolic dysregulation and diabetic myopathy (DM), a complication involving the loss of muscle mass and contractile function. Although hypoxic exercise has demon...

Construction of a federated learning-based privacy-preserving and intelligent recommendation model for educational data

With the development of the advanced educational platform, more and more personalized recommendation systems are used to increase the efficiency of learning and make the dissemination of the educational resources easier. However, educational recommendation tasks involve highly se...

Impact of Climate Change on Sustainable Development in China: A Regional Metabolism Perspective

ABSTRACT Climate change poses considerable challenges to global communities. This study proposes a novel framework that integrates seasonality and resilience to analyze regional metabolic responses to climate change in China. By using urban metabolism based on emergy analysis, th...

Digital technology adoption and relative health deprivation: evidence from China

The rapid expansion of digital technologies has sparked debate over whether they exacerbate or alleviate existing health inequalities, yet empirical evidence from developing countries remains inconclusive. This study investigates the association between digital technology adoptio...

Ion‑Programmed In Situ J‑Aggregates Overcome Concentration‐Dependence for On‐Demand Phototherapy of Diabetic Bacterial Infections

ABSTRACT J‐aggregates are attractive for phototheranostics due to their enhanced absorption, redshift, and photostability, but they typically require high dye concentrations or nanocarriers. Inspired by Derjaguin–Landau–Verwey–Overbeek (DLVO) theory, in which multivalent ions pro...

Trajectory Controllability and Ulam–Hyer's Stability for Higher‐Order Coupled Hilfer Fractional Neutral Stochastic Integro‐Differential Equations via Measure of Non‐Compactness

ABSTRACT The present manuscript investigates the controllability and stability of coupled higher‐order Hilfer fractional neutral stochastic integro‐differential systems (HFNSIDSs) driven by fractional Brownian motion (FBM). To the best of our knowledge, the study of coupled highe...

Open public data and stock price delay: evidence from a quasi-natural experiment in China

Stock price delay serves as a key metric of information efficiency in stock markets, and identifying its determinants is essential for promoting market information efficiency. This study examines the effect of open public data (OPD) on stock price delay. Using the staggered adopt...

Supplementation with Agrobacterium sp. FN01-Derived Crude Product Dominated by L-β-Galactoglucan Enhances Growth Performance and Nutrient Utilization and Modulates Intestinal Microbiota in Pigs

Polysaccharides are well known for their immunomodulatory properties and gut microbiota-regulating functions; however, their digestive stability and structure-dependent biological mechanisms remain poorly understood. This study investigated the in vitro enzymatic resistance and i...

Exploring baryon semileptonic decays through polarization and entanglement

Abstract The unitarity of the Cabibbo–Kobayashi–Maskawa (CKM) matrix is a cornerstone of the standard model (SM). Precise tests of this unitarity require independent determinations of its elements, such as | V us |, which governs the transition between strange and up quarks. Curr...

Synergistic Regulation of Plankton Communities by Polyculture of Grass Carp and Crucian Carp: Seasonal Dynamics and Interaction Networks Based on eDNA

Large-water fisheries are central to China’s freshwater aquaculture, but their sustainability is threatened by eutrophication from traditional high-density stocking. Polyculture of grass carp and crucian carp offers an ecologically sound alternative; nevertheless, its direct effe...

Effects of different resistance training programs on quality of life and fatigue in cancer patients: a network meta-analysis

To systematically evaluate, via network meta-analysis, the effects of different resistance training intensities on quality of life and cancer-related fatigue in cancer patients, and to identify the optimal exercise regimen. A systematic search of PubMed, Embase, the Cochrane Libr...

Reliability and Validity of the Chinese Version of the Parental Acceptance Questionnaire (6‐PAQ) Among Parents of Children With or Without Hearing Loss

ABSTRACT Background The parental acceptance questionnaire (6‐PAQ) is a user‐friendly and contextually sensitive scale of psychological flexibility. Objective This research aimed to translate the original English version of the 6‐PAQ into Chinese and to test its psychometric prope...

Crosstalk Between CTSB + Glioblastoma Cells and S100A10 + Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

ABSTRACT Background : Glioblastoma (GBM) establishes a highly immunosuppressive microenvironment through intricate molecular dialogues with tumor‐associated macrophages (TAMs), contributing to immunotherapy resistance. Methods : We integrated advanced biological network analyses...

A scoping review of virtual reality technology utilization in patients with colorectal cancer

Virtual reality (VR) technology has shown promise in supporting colorectal cancer (CRC) patients throughout their care journey; however, the evidence concerning its specific applications, intervention characteristics, and clinical outcomes remains scattered. This scoping review a...

Maternal di(2-ethylhexyl) phthalate (DEHP) exposure alters offspring gut microbiota and the colonic transcriptome in a sex-specific manner

Maternal exposure to the plasticizer DEHP during gestation and lactation programs lasting sex-specific alterations in offspring intestinal health. This study investigated the transgenerational effects of perinatal DEHP exposure on offspring intestinal health using a C57BL/6 mouse...

multiGMF: A multi-similarity geometric matrix factorization for identifying drug-associated indications

Abstract Drug repositioning serves as a promising strategy in drug development, exploring the potential uses of existing drugs through numerical computation. Compared to experimental screening, drug repositioning proves to be more efficient and cost-effective, playing a vital rol...

Trade‐Offs and Synergies in Cultivated Land Multifunctionality and Zoning Management in the Dongting Lake Region: A Multiscale Analysis

ABSTRACT Understanding the multiscale patterns and interactions of cultivated land multifunctionality is important for conservation, governance, and agricultural spatial optimization in the Dongting Lake region. Using 2020 data, we evaluated economic production (EPF), social secu...

Phase Transition Mediated Solvation Structure Regulation in Quasi‐Solid‐State Composite Electrolyte for High‐Voltage Sodium Batteries

ABSTRACT Quasi‐solid‐state composite electrolytes (QSSEs) represent a promising approach to fabricating high‐energy rechargeable batteries, but their practical implementation is hindered by structural instability and interfacial incompatibility. In this study, a QSSE was prepared...

Laboratory aspirin resistance and the incidence of preeclampsia under prophylactic low-dose aspirin therapy: a systematic review and meta-analysis

A subset of pregnant women treated with prophylactic low-dose aspirin (LDA) still develop preeclampsia (PE), a severe pregnancy-related complication. It is hypothesized that laboratory aspirin resistance (LAR), which may undermine the preventive efficacy of LDA, is associated wit...

Nomogram model based on dual-energy CT quantitative parameters and radiomics for preoperative prediction of microvascular invasion in hepatocellular carcinoma

Abstract Objective To explore the potential value of a nomogram model based on dual-energy CT (DECT) quantitative parameters and radiomics for preoperative prediction of microvascular invasion (MVI) in hepatocellular carcinoma. Methods A retrospective analysis was conducted on 14...