Hunan Normal University

Targeting the m6A reader YTHDF1 for overcoming cancer therapeutic resistance and enhancing tumor immunotherapy

N6-methyladenosine (m⁶A) is a major post-transcriptional RNA modification that regulates RNA stability, translation, degradation, and immune-related gene expression. As a key m⁶A reader, YTHDF1 mainly promotes the translation of m⁶A-modified transcripts and has emerged as an impo...

Logic‐Gated DNA Cascade Amplification Enables High‐Fidelity Intercellular Communication in Synthetic Protocells

ABSTRACT Intercellular communication in synthetic protocells is often constrained by passive diffusion, leading to signal attenuation and spurious activation that limit functional outcomes. Here, we report a programmable communication framework that integrates logic‐gated DNA sig...

An adaptive-problem structure framework for survival relevance in temporal processing

Research on survival-relevant cues and subjective time often groups stimuli into immediate-survival, reproductive, and social categories. These labels do not explain why cues within one category recruit different temporal processes across contexts and perceivers. The Adaptive-Pro...

Arthroscopic 'Luggage Tag' suture repair technique for acetabular labral injuries

This study aimed to evaluate the clinical efficacy of hip arthroscopic luggage-tag suture repair for the treatment of acetabular labral tears. This single-center retrospective study was approved by the institutional ethics committee and enrolled 33 patients with acetabular labral...

Dual-Factor Mental Health Profiles Among Rural School Teachers in China: Associations With Sociodemographic, Occupational, Health Behaviors, and Psychosocial Factors

This study aimed to identify heterogeneous profiles of school teachers in rural China and to examine whether these profiles differed across sociodemographic, work-related, health behavior, and psychosocial factors. Participants were 513 teachers from rural schools in Hunan Provin...

Logic‐Gated DNA Cascade Amplification Enables High‐Fidelity Intercellular Communication in Synthetic Protocells

ABSTRACT Intercellular communication in synthetic protocells is often constrained by passive diffusion, leading to signal attenuation and spurious activation that limit functional outcomes. Here, we report a programmable communication framework that integrates logic‐gated DNA sig...

Mechanism of Multiple Emission in Gold Quantum Boxes and Design Rules for Strong Near-Infrared Luminescence

Abstract Ligand-protected gold nanoclusters (Au NCs) hold great promise for near-infrared photonics and bioimaging, but their low photoluminescence quantum yields (PLQYs) and unclear emission mechanisms have limited the rational design of highly luminescent NCs. Here, we report a...

Noise learning of audio magnetotellurics data with a combination of inception multi-scale residual and dual-decoder U-Net

Abstract Audio magnetotellurics (AMT), as a commonly used reliable geophysical technique, provides outstanding metal ore exploration capabilities based on the resistivity structure of the earth. However, the accuracy of data acquisition is significantly impacted by external elect...

METTL3-mediated m6A modification of RBM39 promotes cancer stemness and tumor progression in head and neck squamous cell carcinoma

Abstract Background RBM39 plays an important regulatory role in multiple cancers. However, its systematic function across pan-cancer and its specific mechanism in head and neck squamous cell carcinoma (HNSC) remain unclear. Materials and methods In this study, we performed pan-ca...

Federated Learning Applications for Cross Cultural Communication Analysis Through Privacy Preserving Integration of Linguistic and Paralinguistic Feature Extraction

Analysis of communication across cultures is essential in global digital interactions, requiring models that capture linguistic and paralinguistic features across diverse cultures. However, existing studies lack privacy-preserving frameworks that can effectively model both lingui...

Lattice-data-driven specific heat and isentropic bulk modulus of SU(3) gluon matter at finite temperature

Abstract We investigate the specific heat and isentropic bulk modulus of finite-temperature pure SU(3) gauge matter within a lattice-data-driven phenomenological framework. The equation of state is formulated in terms of a temperature-dependent effective gluon mass constrained by...

New discoveries of Lanonia (Arecaceae) from northern Vietnam and southwestern China

A new species of Lanonia (Arecaceae, Coryphoideae, Livistoninae) from Lao Cai, Vietnam, Lanonia nhatii sp. nov ., is described and illustrated, and a new record of Lanonia yangchunensis in Guangxi, China, is described based on morphological comparisons, molecular phylogenetic ana...

Afforestation enhances ecosystem stability in the farming-pastoral ecotone of northern China, but its effects are constrained by water availability

Abstract The farming-pastoral ecotone of northern China (FPENC), a typical semi-agricultural and semi-pastoral ecologically fragile zone, has long faced controversy over afforestation due to its water-limited environment, raising concerns about how afforestation affects this frag...

Microhybridization enhances intestinal microbiota and glycometabolic regulation in natural gynogenic blunt snout bream derived from the blunt snout bream (Megalobrama amblycephala, ♀) × Chinese perch (Siniperca chuatsi, ♂)

Gut microbiota plays critical roles in host nutrition and metabolism, but research on the intestinal nutrition and gut microbiota of gynogenetic offspring, especially from omnivorous and carnivorous crosses, remains scarce. Intestinal tissues were collected from natural gynogenet...

Turning Data into Sustainability: Agricultural Big Data Policy, Capital Composition, and Rural Eco-Environmental Sustainability in China

Rural environmental degradation is diffuse, weakly monitored, and hard to govern, and is among the most persistent obstacles to the Sustainable Development Goals (SDGs). Whether treating data as a factor of production relieves this constraint remains unsettled, as does what a rur...

High sperm DNA fragmentation is associated with increased embryonic chromosomal abnormality: a retrospective study of 8 years involving 5637 couples undergoing ART

Abstract STUDY QUESTION Does sperm DNA fragmentation impair blastocyst chromosomal integrity? SUMMARY ANSWER A high sperm DNA fragmentation index (DFI) is associated with an increased risk of blastocyst aneuploidy, particularly when the man has poor semen quality or when the fema...

The lung–brain axis and neuroinflammation: a convergence model and the role of exercise

Pulmonary and neurological disorders are increasingly recognized as interconnected manifestations of systemic neuroimmune dysregulation mediated by the lung–brain axis. Diverse pulmonary insults, including acute respiratory distress syndrome, chronic obstructive pulmonary disease...

The Limits of ESG Disclosure: Nonlinear Effects and Diminishing Returns in Corporate Sustainability

ABSTRACT The rapid expansion of environmental, social, and governance (ESG) disclosure has transformed how firms communicate sustainability commitments, yet whether progressively greater disclosure remains equally associated with stronger environmental outcomes is unclear. This s...

Aptamer-Based Sensing with Fluorescent Light-Up DNA

Abstract DNA aptamers are widely used in the construction of fluorescent sensors, typically employing labelled fluorophores as signaling indicators. However, this covalent labeling approach suffers from several limitations, including complex and costly chemical modification, inco...

Synergistic catalytic therapy of severe acute pancreatitis using gold-doped prussian blue nanozymes via targeting ROS-NLRP3 inflammatory cascade

Severe acute pancreatitis (SAP) is characterized by a complex and poorly understood pathogenesis, with a lack of specific therapeutic agents. Herein, we develop morphology-engineered gold-doped Prussian blue nanozymes (AuPB), designed as reactive oxygen species (ROS) scavengers f...