Hunan Normal University

Laboratory aspirin resistance and the incidence of preeclampsia under prophylactic low-dose aspirin therapy: a systematic review and meta-analysis

A subset of pregnant women treated with prophylactic low-dose aspirin (LDA) still develop preeclampsia (PE), a severe pregnancy-related complication. It is hypothesized that laboratory aspirin resistance (LAR), which may undermine the preventive efficacy of LDA, is associated wit...

Phase Transition Mediated Solvation Structure Regulation in Quasi‐Solid‐State Composite Electrolyte for High‐Voltage Sodium Batteries

ABSTRACT Quasi‐solid‐state composite electrolytes (QSSEs) represent a promising approach to fabricating high‐energy rechargeable batteries, but their practical implementation is hindered by structural instability and interfacial incompatibility. In this study, a QSSE was prepared...

Nomogram model based on dual-energy CT quantitative parameters and radiomics for preoperative prediction of microvascular invasion in hepatocellular carcinoma

Abstract Objective To explore the potential value of a nomogram model based on dual-energy CT (DECT) quantitative parameters and radiomics for preoperative prediction of microvascular invasion (MVI) in hepatocellular carcinoma. Methods A retrospective analysis was conducted on 14...

Quasinormal modes and AdS/CFT correspondence of a rotating BTZ-like black hole in the Einstein-bumblebee gravity

Abstract We obtain exact expressions for the quasinormal modes (QNMs) of the massive scalar, fermionic and vector perturbations around a rotating BTZ-like black hole in the Einstein-bumblebee gravity. We find that the Lorentz symmetry breaking (LSB) parameter $$\ell $$ <mml:math...

HIV status disclosure to sexual partners among gay men and other men who have sex with men: a qualitative meta-synthesis using the social ecological model

Gay men and other men who have sex with men living with HIV face the intersecting effects of HIV-related stigma and stigma against sexual minorities when disclosing their HIV status to sexual partners. Existing reviews have primarily employed quantitative methods and single-level...

Dynamic modeling and optimal control of Mpox among MSM in a central Chinese city

Abstract Background Since 2022, the mpox outbreak has become a global public health threat, with transmission mainly among men who have sex with men (MSM). Mpox is the only infectious disease other than Ebola to have been declared a PHEIC twice. Following its importation and loca...

The comprehensive detection of hemoglobinopathy variants via long-read sequencing

ABSTRACT BACKGROUND The genetic complexity of hemoglobin genes, characterized by high GC content and homologous sequences, poses significant challenges for detecting hemoglobin variants in clinical settings. METHODS A long-read indexed PCR method utilizing the novel CycloneSEQ na...

Dual-organelle–coordinated sonodynamic nanoplatform amplifies immunogenic cell death to drive robust antitumor immunity in cold tumors

Immune-excluded “cold” tumors are characterized by dense stromal barriers, limited cytotoxic T-cell infiltration, and insufficient immunogenic cell death (ICD), which collectively restrict the efficacy of immunotherapy. Pancreatic ductal adenocarcinoma (PDAC) and triple-negative...

Development and validation of a two-gene urine DNA methylation assay for noninvasive prostate cancer detection: a prospective multicenter study

Prostate-specific antigen (PSA) screening lacks specificity, particularly within the 4-10 ng/mL diagnostic gray zone, leading to unnecessary prostate biopsies and overtreatment. Here, we developed and validated a streamlined urine DNA methylation assay for non-invasive prostate c...

Natural Products Targeting Myocardial Fibrosis: Pharmacological Basis, Molecular Mechanisms and Translational Barriers

Myocardial fibrosis (MF) is a hallmark of pathological cardiac remodeling, driven by extracellular matrix (ECM) accumulation, fibroblast activation, and oxidative stress. Diverse natural products—notably alkaloids, flavonoids, terpenoids, and saponins—exhibit emerging antifibroti...

A new type of hybrid bream derived from a hybrid of Megalobrama amblycephala (♀) × Xenocypris davidi (♂)

Blunt snout bream ( Megalobrama amblycephala , BSB, 2 n = 48) is an endemic and economically important freshwater fish in China, characterized by its ease of culture, rapid growth, and high meat quality. However, the industry faces challenges such as germplasm degradation and a l...

Association between the uric acid to high‑density lipoprotein cholesterol ratio and H‑type hypertension: a cross‑sectional study in Chinese adults

The uric acid to high-density lipoprotein cholesterol ratio (UHR) is a novel inflammatory and metabolic biomarker. Studies have confirmed that it is closely associated with the onset and progression of various metabolic and cardiovascular diseases. However, the relationship betwe...

OTOF Promotes Clear Cell Renal Cell Carcinoma Progression and Angiogenesis Through AKT-Dependent HIF/VEGFA Signaling

Background: Clear cell renal cell carcinoma (ccRCC) is characterized by marked molecular heterogeneity, aggressive clinical behavior, and prominent angiogenesis, highlighting the need to better understand the functional regulators underlying tumor progression and vascular remodel...

ModernizingTraditional Mineral Medicine: Pyrolusite-DerivedMnO2 Nanoplatform for Osteo-Angio-Immunomodulatory BoneRepair

Abstract Pyrolusite, a traditional mineral medicine rich in manganese, has long been used to promote fracture healing; however, its complex composition, limited bioavailability, and poorly defined mechanisms have hindered its modernization and clinical translation. Here, we prese...

Prompt Learning for Textual Heterogeneous Information Networks

Heterogeneous information networks (HINs) play an indispensable role in a wide range of domain-specific applications, from recommender systems to conversational platforms. Textual heterogeneous information networks (HINs) are graphs with abundant textual information. Currently, m...