Humanitas University

Announcing The Lancet Regional Health—Europe series on the alarming surge of early-onset colorectal cancer: a multidisciplinary call to action

The rising incidence of early-onset colorectal cancer (EOCRC), defined as a diagnosis in adults younger than 50 years, has emerged as a critical global public health challenge.1 While colorectal cancer (CRC) rates in older populations have stabilized or declined due to successful...

The Hsd17b13P260S patient variant knock-in male mouse model provides translational insights into HSD17B13 biology

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disease that can progress to metabolic dysfunction-associated steatohepatitis (MASH), a condition marked by inflammation and fibrosis that increases the risk of cirrhosis, liver failu...

Real‐time artificial intelligence‐based anatomy recognition in single‐port transvesical enucleation of the prostate

Objectives To evaluate the feasibility and accuracy of an artificial intelligence (AI) model to assist surgeons through automated real‐time detection and segmentation of key anatomical structures during robot‐assisted single‐port transvesical enucleation of the prostate (STEP). P...

Ipsilateral inhibitory rTMS restores interhemispheric motor cortex balance and reduces phantom limb pain: an exploratory longitudinal nTMS mapping study

Abstract Background Phantom limb pain (PLP) is a debilitating condition associated with maladaptive neuroplastic changes following limb amputation. The prevailing neuromodulatory approach targets the deafferented contralateral motor cortex, yet interhemispheric imbalance is incre...

Ringing the Bell in Cancer Care: A Scoping Review of Patients’, Caregivers’, and Healthcare Professionals’ Experiences and Implications for Oncology Nursing

BACKGROUND: Bell-ringing rituals mark the end of active cancer treatment in oncology settings worldwide. Despite their growing prevalence, their emotional and clinical implications across patients, caregivers, and healthcare professionals remain underexplored. OBJECTIVE: To map a...

Long-Term Recovery Trajectories After Endovascular Treatment of Carotid-Cavernous Fistulas: A Single-Center Cohort Study

BACKGROUND AND OBJECTIVES: Carotid-cavernous fistulas (CCFs) are uncommon arteriovenous shunts that can present with a wide range of nonspecific ophthalmic and neurological symptoms, often leading to diagnostic delays. While endovascular embolization is the primary treatment moda...

Comparative Efficacy Of Different Computer-Aided Detection Products in Colonoscopy: A Network Meta-Analysis Of Randomized Controlled Trials.

Background and aims: Multiple computer-aided detection (CADe) systems have been developed to improve adenoma detection during colonoscopy, but their comparative efficacy and consistency of effect remain uncertain. This network meta-analysis aimed to compare the efficacy of differ...

The COACH theory formalizes clinical reasoning in the development and validation of medical artificial intelligence systems

The development and deployment of medical artificial intelligence (AI) systems are limited by two persistent gaps: clinician knowledge is often introduced late in development as labels or annotations, and deployed systems often provide outputs that are difficult to reconcile with...

Endovascular Thrombectomy for Cerebral Venous Thrombosis: Current Status and Future Directions

Abstract Cerebral venous thrombosis (CVT) represents a relatively rare cause of stroke, yet it carries an overall rate of death or dependency of up to 15%. The mainstay of its management is therapeutic anticoagulation, either subcutaneously or intravenously in the acute phase, fo...

Readmission to hospital after thoracic trauma: better safe than sorry! the predictive read score

Thoracic trauma accounts for approximately 10–15% of trauma admissions and contributes substantially to trauma-related morbidity and mortality. Readmission rates for thoracic trauma have not been investigated thus far; thus, the purpose of this retrospective study is to reduce pa...