Hubei University of Medicine

Genome-wide annotation of human multi-nucleotide variants reveals widespread functional differences from single nucleotide variants

Multi-nucleotide variants (MNVs) represent a crucial yet underexplored category of genetic variation. Despite previous studies highlighting the prevalence and potential biological impact of MNVs in populations, comprehensive identification and detailed functional annotation of MN...

Development of a treatment classification system and treatment strategy for ligamentous ossification disease-traditional and innovative surgical strategies

Ligamentous ossification diseases like OPLL and OLF can cause severe neurological compromise. While whole-spine CT identifies ossified segments and MRI reveals cord compression/signal changes, treatment guidelines—especially for multi-level involvement—remain undefined, particula...