Hubei University of Medicine

Harnessing cell cycle synchronization to boost the therapeutic potential of umbilical cord MSCs against acute colitis

Abstract Human umbilical cord mesenchymal stromal cells (UCMSCs) are multipotent stem cells with strong immunomodulatory capacity, ease of acquisition, low immunogenicity, and a non-tumorigenic nature, making them attractive candidates for tissue repair. Under standard culture co...

Prognostic factors and nomograms predicting overall survival and cancer specific survival for patients with rare histological variant prostate cancer

Our study aimed to develop nomograms to accurately predict the 1-, 3-, and 5-year overall survival (OS) and cancer-specific survival (CSS) of patients with rare histological variant prostate cancer (PCa) based on clinicopathological characteristics. We gathered clinicopathologica...

Vaginal microbiome and metabolome profiling identifies candidate signatures associated with persistent high-risk HPV infection

Abstract The role of vaginal microbiota dysbiosis in the progression of human papillomavirus (HPV) infection is increasingly recognized. Yet, the factors determining why only a minority of infections persist and evolve into clinically significant disease remain poorly defined. Fr...

Short term clinical outcomes associated with ticagrelor + aspirin versus clopidogrel + aspirin following endovascular therapy for un-ruptured cerebral aneurysm: a meta-analysis

Nowadays endovascular therapy has become the first line treatment for the management of patients with un-ruptured intracranial aneurysms. However, the risk of thromboembolic events secondary to the use of intracranial stents is a major concern. The use of anti-platelet agents fol...

Driver state detection and recognition in conditional automated driving: A review

SAE Level 3 automated driving systems assume full control of the dynamic driving task within their operational design domain. Ensuring a safe and timely transition from automated to manual driving therefore necessitates continuous monitoring and assessment of driver state. This r...

Porcine Sertoli cell exosomes tune the redox setpoint of spermatogonial stem cells through PSMD11–p38 MAPK signaling to mediate differentiation

Spermatogonial stem cell (SSC) fate—the choice between self-renewal and differentiation—is governed by intercellular signaling within the testicular niche. A central paradigm holds that endogenous reactive oxygen species (ROS) sustain SSC self-renewal through MAPK signaling. Yet...

Undernutrition enhances host attractiveness to mosquitoes and transmission of mosquito-borne diseases

Undernutrition is prevalent in regions affected by mosquito-borne diseases. Understanding how insufficient nutrition affects the transmission of mosquito-borne pathogens is critical for combating these diseases. In this study, we found that undernourished mice were more attractiv...

Longitudinal Study on Post‐Traumatic Stress Disorder, Anxiety, and Depression Among Medical Staff in China

ABSTRACT Background Evidence of the longitudinal relationship between anxiety, depression, and post‐traumatic stress disorder (PTSD) is not uniform. This study aimed to explore the dynamic changes, independent factors, and bidirectional predictive relationships of anxiety, depres...

PTK6 inhibition by tilfrinib hinders the proliferation and migration of ovarian cancer cells

Protein Tyrosine Kinase 6 (PTK6) has been implicated in the progression of multiple malignancies; however, its oncogenic role and therapeutic potential in ovarian cancer (OC) remain incompletely defined. This study systematically investigates the biological function and therapeut...

Intrauterine Pregnancy Combined With Ovarian Pregnancy Was Missed by Ultrasound: A Case Report

ABSTRACT A 32‐year‐old G2P0 female presented with 4+ weeks of amenorrhea and acute‐onset lower abdominal pain with vaginal bleeding. Initial ultrasound confirmed a 6+ week intrauterine pregnancy. The patient underwent painless uterine curettage on the third day because the patien...

Probiotic Spore Inspired Oral Drug Delivery System With Multiple‐Barriers‐Crossing Ability Modulates Gut‐Brain Axis for Parkinson's Disease Therapy

ABSTRACT For Parkinson's disease (PD), the development of oral brain‐targeted drug delivery is challenging due to various physiological barriers. Besides the brain, the effect of the gut on the microbiome‐gut‐brain axis should not be ignored. Therefore, developing a gut‐brain dua...

Association of stress hyperglycemia ratio trajectories and cumulative stress hyperglycemia burden with in-hospital mortality in ICU patients with heart failure: a retrospective cohort study

Heart failure (HF) is a major global health concern, and traditional prognostic markers incompletely reflect acute stress status. Although the stress hyperglycemia ratio (SHR) better assesses acute glycemic burden and correlates with adverse outcomes in critically ill HF patients...

Heart failure may promote breast cancer progression through a Col10a1-associated Tgf-β/Smad-EMT pathway

Heart failure (HF) is clinically associated with aggravated breast cancer (BC) progression; however, the integrative genomic mechanisms underlying this cardio-oncological crosstalk remain poorly understood. We conducted integrative bioinformatics analyses combining weighted gene...

SPR‐UPLC‐QTOF/MS‐GNPS‐Guided Discovery of Hypermonol J as a Novel Tumor Necrosis Factor‐Binding Small‐Molecule Lead for Inflammatory Storm Intervention

ABSTRACT This study developed an integrated strategy combining surface plasmon resonance (SPR) for real‐time biomolecular interaction analysis, ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry (UPLC‐QTOF/MS) for compound profiling,...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Associations and potential utility of composite obesity and metabolic indices for osteoporosis risk assessment in Chinese adult men: a cross-sectional study

Osteoporosis in men is associated with substantial morbidity and mortality, yet simple tools for preliminary risk assessment remain limited. The aim of this study is to examine the associations and potential utility of composite obesity- and metabolism-related indices for osteopo...

Clinicopathological characterization and prognostic significance of HER2-low expression in endometrial cancer: a ProMisE molecular classification-based analysis

Antibody–drug conjugates have renewed interest in tumors with low-level HER2 expression. However, the clinicopathological distribution and prognostic significance of HER2-low status in endometrial cancer, particularly across ProMisE molecular subtypes, remain uncertain. This sing...

Rural-urban divergence in healthy aging: differential associations of social support versus individual attributes in China

Against the backdrop of population aging, promoting healthy aging is a core strategy for aging governance in China. Driven by unbalanced rural–urban development, the associations between relevant factors and healthy aging among older adults may exhibit distinct rural–urban hetero...

Intermittent fasting promotes plaque regression and activates the BMAL1–MERTK efferocytosis axis

Abstract Background Atherosclerotic cardiovascular disease can progress despite intensive lipid lowering, highlighting the need to identify local mechanisms that remodel established plaques. Intermittent fasting may engage metabolic, circadian, and immune pathways relevant to thi...

An ioversol-enhanced micro-CT workflow for hematoma visualization and preoperative localization in a murine autologous blood model of intracerebral hemorrhage

Abstract Autologous blood injection produces a discrete striatal clot in mice, but the hematoma is usually confirmed only after brain removal and sectioning, making craniotomy planning difficult for evacuation studies. To address this limitation, we mixed freshly collected autolo...