Hubei University of Medicine

Associations and potential utility of composite obesity and metabolic indices for osteoporosis risk assessment in Chinese adult men: a cross-sectional study

Osteoporosis in men is associated with substantial morbidity and mortality, yet simple tools for preliminary risk assessment remain limited. The aim of this study is to examine the associations and potential utility of composite obesity- and metabolism-related indices for osteopo...

Clinicopathological characterization and prognostic significance of HER2-low expression in endometrial cancer: a ProMisE molecular classification-based analysis

Antibody–drug conjugates have renewed interest in tumors with low-level HER2 expression. However, the clinicopathological distribution and prognostic significance of HER2-low status in endometrial cancer, particularly across ProMisE molecular subtypes, remain uncertain. This sing...

Rural-urban divergence in healthy aging: differential associations of social support versus individual attributes in China

Against the backdrop of population aging, promoting healthy aging is a core strategy for aging governance in China. Driven by unbalanced rural–urban development, the associations between relevant factors and healthy aging among older adults may exhibit distinct rural–urban hetero...

Intermittent fasting promotes plaque regression and activates the BMAL1–MERTK efferocytosis axis

Abstract Background Atherosclerotic cardiovascular disease can progress despite intensive lipid lowering, highlighting the need to identify local mechanisms that remodel established plaques. Intermittent fasting may engage metabolic, circadian, and immune pathways relevant to thi...

An ioversol-enhanced micro-CT workflow for hematoma visualization and preoperative localization in a murine autologous blood model of intracerebral hemorrhage

Abstract Autologous blood injection produces a discrete striatal clot in mice, but the hematoma is usually confirmed only after brain removal and sectioning, making craniotomy planning difficult for evacuation studies. To address this limitation, we mixed freshly collected autolo...

Genome-wide annotation of human multi-nucleotide variants reveals widespread functional differences from single nucleotide variants

Multi-nucleotide variants (MNVs) represent a crucial yet underexplored category of genetic variation. Despite previous studies highlighting the prevalence and potential biological impact of MNVs in populations, comprehensive identification and detailed functional annotation of MN...

Development of a treatment classification system and treatment strategy for ligamentous ossification disease-traditional and innovative surgical strategies

Ligamentous ossification diseases like OPLL and OLF can cause severe neurological compromise. While whole-spine CT identifies ossified segments and MRI reveals cord compression/signal changes, treatment guidelines—especially for multi-level involvement—remain undefined, particula...