Hubei Provincial Center for Disease Control and Prevention

Diagnostic Performance of Donor‐derived Cell‐free DNA Combined With Immune Activation Markers for Detecting Acute Rejection After Liver Transplantation

BACKGROUND: Accurate differentiation of acute rejection (AR) from other causes of graft dysfunction after liver transplantation remains challenging in real-world clinical practice. Although donor-derived cell-free DNA (dd-cfDNA) has emerged as a promising non-invasive biomarker o...

Bladder Sensory Neurons as Regulators of Neuro-Immune-Urothelial Interactions: From Molecular Mechanisms to Targeted Therapy for Neurogenic Bladder and Interstitial Cystitis/Bladder Pain Syndrome

Bladder sensory neurons are essential components of lower urinary tract sensory encoding and micturition reflex control. They detect bladder filling, stretch, inflammatory mediators, and pathogen-associated stimuli, and they communicate with urothelial cells, immune cells, and st...

Large language models for literature screening in conceptually complex and interdisciplinary reviews

Purpose This study examines the capabilities and limitations of large language models (LLMs) for literature screening in systematic reviews involving conceptually diffuse and interdisciplinary topics. Design/methodology/approach Two screening datasets were constructed. Four LLMs,...

Targeted degradation of RAGE restores microglial homeostasis and rescues cognitive deficits in 3xTg-AD mice

Chronic neuroinflammation and microglial dysfunction lie at the core of Alzheimer’s disease (AD) pathogenesis. The Receptor for Advanced Glycation End-products (RAGE) serves as a pivotal upstream driver of this inflammatory cascade and associated oxidative stress. However, conven...

Targeted microglial ROS-scavenging alleviates neuroinflammation and cognitive deficits via restoration of the 2-AG/CB2R signaling axis in schizophrenia

Cognitive impairment in schizophrenia is inadequately treated. The molecular link between oxidative stress and neuroinflammation in its pathophysiology remains unclear. We measured CB2R in circulating microglia‑derived exosomes from schizophrenia patients and healthy controls. In...

METTL14‐Mediated N6‐Methyladenosine Exacerbates Acute Lung Injury via USP30/NCOA4‐Dependent Ferroptosis

ABSTRACT Ischemia/reperfusion (I/R)‐induced acute lung injury (ALI) is a severe clinical syndrome characterized by alveolar epithelial damage, oxidative stress, and acute respiratory failure, but the epitranscriptomic mechanisms linking N6‐methyladenosine (m6A) modification to fe...

Adolescent environmental enrichment prevents early-life stress-induced schizophrenia-like phenotypes via restoration of CREB-BDNF-TrkB signaling

Early-life stress (ELS) is a major environmental risk factor for schizophrenia, yet effective preventive strategies targeting its neurodevelopmental consequences remain limited. Here, we show that adolescent environmental enrichment (EE) prevents the emergence of schizophrenia-li...

Prevalence of Keshan disease at the township level in China: a cross-sectional study

Keshan disease (KD), an endemic myocardiopathy with unclear etiology, lacks primary preventive measures. This study aimed to assess the prevalence of KD at the township level using spatial epidemiology, elucidate its distribution characteristics for further precision classificati...

The efficacy, immunogenicity and safety of the LZ901 vaccine for herpes zoster virus in adults 40 years of age or older: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

In previously completed Phase 1 and 2 clinical trials, a recombinant gE-Fc fusion protein subunit vaccine adjuvanted with aluminum hydroxide (called LZ901) demonstrated favorable safety profiles and elicited robust immune responses. This randomized, placebo-controlled, double-bli...

Apoptosis of Mdm2-deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles

During homeostasis, osteocyte apoptosis is typically associated with bone loss through enhanced osteoclast recruitment and bone resorption. However, whether apoptotic osteocytes also regulate bone formation remains elusive. Here we report that conditional deletion of Mdm2, an E3...