Huazhong Agricultural University

Iteratively DesignedPhospholipid-Targeted SupramolecularSonosensitizers for Precision Treatment of Pulmonary Infections

Abstract Fungal infections represent a significant global health threat, exacerbated by the scarcity of new therapeutic options, increasing drug resistance, and host toxicity. Sonodynamic therapy (SDT) offers a promising approach to overcoming antimicrobial resistance by enabling...

Threshold-window framework reveals management-sensitive controls of CH4 and N2O emissions in flooded rice

Rice paddies are major sources of methane (CH 4 ) and nitrous oxide (N 2 O), yet co-managing water and nitrogen (N) to limit both gases remains challenging because emissions arise from non-linear interactions among multiple drivers. We combined a two-year field experiment in subt...

Nutrient–Microbiota Co-Regulation of Protein Conversion in Black Soldier Fly Larvae: The Role of Alkali-Soluble Protein and Gut Microbial Communities

Insect protein farming provides sustainable advantages in land efficiency, emission reduction, and bioconversion. A major challenge is optimizing nutrient composition to achieve cost-effective protein production. This study investigates the co-regulatory mechanism between alkali-...

Biocontrol of tomato soilborne diseases by fungivorous nematode Aphelenchoides bicaudatus

<title>Abstract</title> Crop soil-borne diseases caused by pathogens, such as Fusarium spp. and root-knot nematodes, contribute to substantial yield losses worldwide. This study investigated the biocontrol potential of the fungivorous nematode, Aphelenchoides bicaudatus isolate A...

TPS10 contributes to linalool emission in rice in response to brown planthopper infestation

Abstract BACKGROUND Terpenoids, a prominent class of herbivore‐induced plant volatiles, play a crucial role in plant responses to insect attacks. However, the precise ecological functions of individual terpene synthases in rice defense mechanisms remain unclear. RESULTS The level...

Spinetoram‐based seed‐pelleting with synergistic mixtures enhances control of the diamondback moth

BACKGROUND: The diamondback moth, Plutella xylostella, is one of the most destructive pests of cruciferous crops worldwide. Its high fecundity, stress tolerance and seasonal migration often render traditional spray control ineffective. In this study, we propose an alternative met...

A Label‐Free Bioluminescent scFv‐NLuc Fusion Probe Enabling a Smartphone‐Based Sensitive Immunoassay Platform Using Lomefloxacin as a Model Analyte

ABSTRACT Enzymes as labeling agents enhance lateral flow immunoassays (LFIA). However, their biological instability and reliance on labor‐intensive chemical conjugation hinder practical high‐throughput screening of food contaminants. To address this, we report a rapid, label‐free...

Thiram Disrupts Hepatic and Tibial Calcium Homeostasis via ER Stress‐Mediated IP3R1 / VDAC1 Hyperactivation

ABSTRACT Thiram is an agricultural fungicide known to disrupt cellular calcium homeostasis by inducing endoplasmic reticulum (ER) stress and mitochondrial calcium overload in hepatic and growth plate (GP) tissues. Current study investigated thiram‐induced alterations at mitochond...

Genetic Determinants of Milk Production Phenotypes in Dairy Goats: A Review

Dairy goats sustain milk production across marginal environments worldwide, yet genetic improvement of milk yield and composition remains slower than in cattle, constrained by smaller reference populations and limited functional validation. This review consolidates current eviden...

Land marketization, fiscal decentralization and carbon emissions

During China’s period of economic transition, its policy of fiscal decentralization (FD) has vigorously promoted China’s economic development, but it has brought about a mass of carbon emissions (CE) from its urban and industrial development. To solve environmental problems, the...

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Pooled CRISPR screening enables genome-scale functional gene discovery by linking genetic perturbations to cellular phenotypes. However, its application in insects remains limited, as systematic differences often obscure the universal functional signals and compromise the reliabl...

Associations of Breed and FUT1 Genotype with the Fecal Microbiota of Weaned Piglets

This study aimed to analyze the associations between the composition and function of the gut microbiome in weaned piglets of different breeds and Fucosyltransferase 1 (FUT1) genotypes. Ear tissue and fecal samples were collected from 163 piglets (61 Durocs, 39 Yorkshires, and 63...

A study on basketball formation recognition based on the Swin Transformer algorithm

Abstract Basketball tactical states span possession phase, defensive coverage, pressure intensity, and offensive organization, and therefore cannot be represented reliably by a single mutually exclusive label. A temporal-order-aware Swin Transformer is developed as a hierarchical...

Genome-wide annotation of human multi-nucleotide variants reveals widespread functional differences from single nucleotide variants

Multi-nucleotide variants (MNVs) represent a crucial yet underexplored category of genetic variation. Despite previous studies highlighting the prevalence and potential biological impact of MNVs in populations, comprehensive identification and detailed functional annotation of MN...

Enzyme Engineering:From Classical Strategies to AI-DrivenBiocatalyst Design

Abstract Nowadays, enzyme engineering has moved from traditional structure-based mutagenesis and directed evolution to data-intensive, AI-assisted design paradigms that involve the rapid discovery and optimization of biocatalysts. Whereas classical approaches relied on rational d...

From “Time is money” to “Time is life”: cyberslacking and the moralization of time in contemporary China

This article investigates cyberslacking in contemporary China through the lens of time moralization, framing it as a morally contested response to capitalist temporal regimes, rather than mere individual deviance. Drawing on 35 semi-structured interviews within the Douban group “...

Sugar-binding protein MalE mediates cadmium immobilization and promotes biofilm formation in microbial communities

Microbial communities survive in stressful environments like cadmium (Cd) contamination through adaptive responses. Cd pollution is frequently associated with elevated zinc (Zn); however, how microorganisms utilize Zn to shape community structure remains unclear. Here, we find th...

Structural Basis for the Immunological Paradox of a High-Affinity Yet Non-Immunogenic MHC-I Epitope from Cryptosporidium parvum

Cryptosporidium parvum is an important apicomplexan parasite that causes severe diarrheal disease in children and immunocompromised individuals. However, the structural basis for the limited immunogenicity of its T-cell epitopes remains poorly understood. This study integrates st...

Polymer Substrates for Flexible Sensors: Advances and Contributions to Smart Agriculture

ABSTRACT The advancement of smart agriculture is becoming increasingly dependent on sensor technologies that enable the digitization and optimization of agricultural processes. Traditional sensors, however, are constrained by their inherent rigidity, poor conformability to irregu...

Enhancing Mn(II)/Mn(IV) Redox Activity and Reducing Polarization of NASICON‐Type Na 3 MnTi(PO 4 ) 3 Through Al‐Doping

ABSTRACT NASICON‐type cathode materials have garnered significant interest for their stable structure and favorable Na + diffusion pathways. However, Na 3 MnTi(PO 4 ) 3 (NMTP) often suffers from substantial voltage hysteresis and limited capacity, primarily attributed to intrinsi...