Hospital for Special Surgery

Pediatric Patellofemoral Instability Surgery—Current Concepts

Patellofemoral instability is a common knee pathology affecting children and adolescents, with recurrence rates exceeding 50% in skeletally immature patients. Identification and stratification of anatomic risk factors for recurrence are essential. Trochlear dysplasia, patella alt...

Patellofemoral Joint Preservation

Patellofemoral (PF) chondral lesions are a common source of knee pain and disability, typically arising from traumatic (instability/fracture) or degenerative (overload) etiologies. This review synthesizes contemporary evidence on PF joint preservation with an emphasis on avoiding...

TRAIL splice variant TRAILshort disrupts T cell receptor signaling and promotes immune tolerance in vivo

TRAIL is a TNF family ligand that trimerizes TRAIL-R1 (DR4) or TRAIL-R2 (DR5) to induce apoptosis, necroptosis, and/or NF-κB activation in receptor-bearing cells. We previously identified TRAILshort as a splice variant of TRAIL that lacks cysteine 230, cannot trimerize, and acts...

Glucagon-like peptide-1 receptor agonists are associated with improved 90-day outcomes after total hip and knee arthroplasty

Aims Obesity and diabetes are risk factors for developing osteoarthritis and associated with worse outcomes following total hip (THA) and total knee arthroplasty (TKA). Glucagon-like peptide-1 receptor agonists (GLP-1as) improve glycaemic control and promote weight loss. The aim...