Hospital for Special Surgery

Changes in Coronal and Sagittal Plane Alignment After Transphyseal ACL Reconstruction Performed Within Two Years of Skeletal Maturity: Results From the PLUTO Study Group

Background: For patients with open physes approaching skeletal maturity, transphyseal anterior cruciate ligament reconstruction (ACLR) with soft tissue autograft and metaphyseal fixation is often preferred. Although iatrogenic physeal injury is rare, growth disturbances have been...

Exploration of the genetic architecture of ANCA-associated vasculitis

Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a complex autoimmune disease with distinct clinical and serological subtypes. Previous genome-wide association studies (GWAS) have identified several susceptibility loci, particularly within the major h...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

Adult Cervical Deformity: Contemporary Evaluation, Classification, and Surgical Decision-Making

➢ Standing full-spine radiographs are mandatory for cervical deformity evaluation; key alignment targets include cervical sagittal vertical axis (cSVA) of ≤40 mm, T1 slope minus cervical lordosis (T1S − CL) of <15°, and a chin-brow vertical angle (CBVA) between −10° and +10° rela...

3D articular knee shape drives increased anterior cruciate ligament (ACL) loading in young, active individuals with ACL injury and females

Abstract Background ACL rupture is a common, debilitating injury in young, active individuals. Some individuals sustain ACL injury while others do not, despite similar activity exposure. Young, active females have more than twice the ACL injury risk of males. Interactions among t...

Diaphyseal zonal fixation in revision total knee arthroplasty

The concept of zonal fixation for the distal femur and proximal tibia has revolutionized our understanding of how to best achieve durable fixation in revision total knee arthroplasty. However, the diaphyseal zone covers most of the femur, and achieving durable diaphyseal fixation...

Fluoroscopy Computer Navigation Versus Manual Fluoroscopic Acetabular Positioning in Direct Anterior Total Hip Arthroplasty: Safe Zone Compliance and Learning Curve Analysis

Background Fluoroscopy is commonly leveraged in direct anterior approach total hip arthroplasty (DAA-THA). Computer-navigation systems provide real-time guidance aiming to enhance component positioning, but their learning curves and component accuracy remains incompletely charact...

A NOVEL SMART IMPLANTABLE DEVICE DEMONSTRATES EARLY GAIT DECLINE AS A MARKER OF PERIPROSTHETIC JOINT INFECTION AFTER TOTAL KNEE ARTHROPLASTY

Abstract Background Periprosthetic joint infection (PJI) remains a major cause of early failure after total knee arthroplasty (TKA), yet early diagnosis is difficult and often delayed. Continuous physiologic monitoring from smart implantable devices may offer earlier insight into...

HIGH BONE STRAINS HELP US TO UNDERSTAND MIGRATION OF CEMENTLESS TIBIAL BASEPLATES

This study evaluated the relationship between bone strain patterns and early migration of cementless tibial baseplates following robotically assisted total knee arthroplasty (TKA). Ten patients undergoing cementless cruciate-retaining TKA had CT scans including a BMD reference ph...

No Difference in Short-term Postoperative Complication Rates Between Non-chilled and Chilled Saline Irrigation in Percutaneous Foot and Ankle Surgery

Background: The advent of minimally invasive percutaneous foot and ankle surgery techniques has helped to lower certain complication rates, including wound infection and nonunion. The percutaneous burr is the work horse to perform these procedures. One concern with burr usage is...

PARTIAL POSTERIOR CRUCIATE LIGAMENT RELEASE IN TOTAL KNEE ARTHROPLASTY MITIGATES EXCESSIVE ROLLBACK WITHOUT COMPROMISING IMPLANT FIXATION

Introduction Balancing the posterior cruciate ligament (PCL) remains challenging in total knee arthroplasty (TKA). Excessively tight PCL can limit range of motion, cause excessive femoral rollback, and induce anterior implant liftoff. While selectively releasing a tight PCL can r...

The Effect of Post-Traumatic Stress Disorder on Total Shoulder Arthroplasty Outcomes: A Retrospective Cohort Study

Background: Total shoulder arthroplasty (TSA) continues to have increased use, and about 6 out of every 100 individuals are diagnosed with post-traumatic stress disorder (PTSD). Previous studies have shown that PTSD affects bone health and joint arthroplasty outcomes. Although bo...

Level-dependent changes in cervical multifidus composition following anterior cervical discectomy and fusion: bridging quantitative MRI and clinical perspectives

Fatty infiltration (FI) of the cervical paraspinal muscles is associated with greater disease severity and less favorable outcomes in degenerative cervical spine disease. However, longitudinal data on whether muscle composition changes following anterior cervical discectomy and f...

The Femoral Impingement Index Predicts Inferior Clinical Outcomes in Men Undergoing Hip Arthroscopy for Femoroacetabular Impingement Syndrome

PURPOSE: To evaluate the association of femoral version, McKibbin index, and femoral impingement index (FII) on patient-reported outcomes after primary hip arthroscopy for femoroacetabular impingement syndrome. METHODS: We retrospectively reviewed prospectively collected data fro...

Intranodal Embolization of Lymphocele Following Anterior Lumbar Interbody Fusion: Case Report

Postsurgical lymphocele is a rare complication following anterior lumbar interbody fusion (ALIF), for which ideal management remains controversial. Our study presents a case of a 70-year-old woman who underwent a multilevel anterior and posterior fusion from L3 to the pelvis with...

Patients' perceptions of diet and exercise interventions for knee osteoarthritis and barriers to optimal treatment

BACKGROUND: Changing diet and exercise behaviors are first-line lifestyle interventions to treat knee osteoarthritis (OA), but many patients fail to adhere to recommended guidelines. OBJECTIVE: To determine the perceptions, trends and barriers related to healthy diet and exercise...

Advancements in Imaging for the Overhead Athlete: A Narrative Review

Overhead throwing athletes place unique stresses on the soft tissues of the core and upper extremities, predisposing them to both acute and chronic overuse injuries. In addition to clinical factors and examination, imaging techniques aid in the diagnosis and management of these c...

Two Decades of Declining International Medical Graduate Representation in Physical Medicine and Rehabilitation Residency Programs

OBJECTIVE: To evaluate trends of international medical graduates (IMGs) matching into U.S. physical medicine and rehabilitation (PM&R) residency programs. DESIGN: This retrospective cohort study analyzed National Resident Matching Program data from 2005 to 2025. The primary outco...

Discovery of a peripheral Myh11-expressing nucleus pulposus cell population demontrating therapeutic potential for disc degeneration

Continual turnover of nucleus pulposus (NP) cellularity is critical for maintaining intervertebral disc (IVD) homeostasis; however, the presence and identity of potential progenitor cells within the NP remain unclear. This study identifies NP cells expressing myosin heavy chain 1...

Pediatric Patellofemoral Instability Surgery—Current Concepts

Patellofemoral instability is a common knee pathology affecting children and adolescents, with recurrence rates exceeding 50% in skeletally immature patients. Identification and stratification of anatomic risk factors for recurrence are essential. Trochlear dysplasia, patella alt...