Hiroshima University

Optimized Flomoxef Dosing Strategy for Extended-Spectrum Beta-Lactamase-Producing Bacteria, Based on Pooled Pharmacokinetic and Pharmacodynamic Analysis

Background: Flomoxef exhibits antibacterial activity against extended-spectrum beta-lactamase (ESBL)-producing bacteria and is a potential alternative to carbapenems. However, its pharmacokinetic (PK) characteristics remain unclear, and the appropriate minimum inhibitory concentr...

When Premium Product Strategy Meets Sustainability: Environmental–Economic Trade‐Offs in Japanese Manufacturing

ABSTRACT Corporate sustainability has become a central concern for business stakeholders, yet little is known about how premium product strategies shape firms' sustainability orientations and performance. Drawing on stakeholder theory, this study examines whether pursuing premium...

Rethinking Behavioral and Psychological Symptoms of Dementia in Severe Alzheimer's Disease: From Intentional Explanation to an Ecological, Body–Environment Framework

In contemporary dementia care, behavioral and psychological symptoms of dementia (BPSD) are often understood as expressions of the person's intentions or needs. This paper examines the limits of understanding BPSD as "expressions of intention" in severe Alzheimer's disease. It ar...

Facet Selectivity Enables Near-Unity External Quantum Yields in Shell-free Silicon Quantum Dots

Abstract Core–shell quantum dots (QDs) such as epitaxially passivated CdSe, InP, and lead-halide perovskite QDs, which are often used in solar cells and as photocatalysts, are highly luminescence-efficient and tunable. However, concerns surrounding sustainability, toxicity, and m...

Hydration Kinetics of Calcium Oxide in a Solid–Gas System: A Critical Process for Thermochemical Energy Storage

Abstract The present study investigated the intrinsic kinetic behavior of the hydration reaction of CaO to form Ca(OH)2, which is the counterpart reaction to the thermal dehydration of Ca(OH)2 in the reversible reaction processes utilized in a thermochemical energy storage system...

Bridging skills gaps: how micro-credentials reshape sustainable development learning in higher education

Abstract Micro-credentials (MCs) are gaining traction in higher education as essential tools for advancing sustainable development (SD). These short, focused courses provide learners with specific skills and knowledge related to sustainability, enabling them to address pressing g...

Association between meal timing regularity and oral health behaviors

Good oral health habits may be related to the regularity of food intake; however, these relationships have not been well-explored. This study examined the association between meal timing regularity and oral health behaviors, focusing on consistent weekday and weekend meal schedul...

Systematic mutagenesis assay promotes comprehension of the strand-bias laws for mutations induced by oxidative DNA damage

Ionizing radiation-induced cancer is largely indistinguishable from spontaneous cancer, particularly following low-dose and low-dose-rate exposures, making the underlying mutational mechanisms difficult to define. Under such exposure conditions, radiation-generated reactive oxyge...

From Sprain to End-Stage Osteoarthritis: Why Earlier Intervention in Ankle Cartilage Damage Deserves More Attention

➢ Ankle cartilage damage ranges from osteochondral lesions of the talus to end-stage osteoarthritis. End-stage ankle osteoarthritis has been associated with a health burden comparable with that of major chronic diseases such as congestive heart failure and kidney disease, while p...

Water Activity Governs Ice Nanocrystal Evolution in Rapidly Frozen Sugar Solutions

Abstract Formation and evolution of ice nanocrystals in rapidly frozen sugar solutions were investigated using spin-contrast-variation small-angle neutron scattering (SCV-SANS). As the sugar concentration decreased, the SCV-SANS signal from nanocrystalline ice plates decreased re...

Pediatric health events during disaster response: a multi-disaster analysis of emergency medical team records in Japan, 2016–2020

Children are particularly vulnerable during disasters; however, comprehensive data on pediatric health events across multiple disasters are lacking. This study aimed to characterize the health events affecting children during disaster response using disaster medical records from...

Can Non‐Orthogonal Bases Form Stable Skyrmionic Beams?

ABSTRACT Skyrmions, topologically stable spin textures, have recently garnered significant attention in optics, promising robust high‐density information transmission and nontrivial light‐matter interaction. Optical skyrmionic beams have generally been considered to require the s...

Hour-scale response of low-Earth-orbit satellite altitude to extreme geomagnetic storms revealed by the NinjaSat CubeSat during the 2024 solar maximum

Abstract Extreme geomagnetic storms accelerate low-Earth-orbit satellite decay by inflating the thermosphere, yet the hour-scale pathway from solar-wind energy to atmospheric heating is poorly understood. Using the GNSS receiver of the NinjaSat CubeSat ( $$\sim 500$$ km, $$97^\ci...

Sugammadex versus no pharmacological reversal under quantitative neuromuscular monitoring: a propensity score–matched analysis of postoperative pulmonary complications

Sugammadex may reduce postoperative pulmonary complications (PPCs). However, its association with PPCs remains unclear when quantitative neuromuscular monitoring (NMT) is routinely used, and comparisons with spontaneous recovery are limited. We compared PPCs between cases receivi...

Contested Liberalisms in Mexico: Popular Liberalism, the Fourth Transformation, and the Struggle over Constitutional Identity

Mexico's Cuarta Transformación (4T) is usually read as one instance of a global illiberal turn. This article argues instead that the Mexican constitutional conflict is internal to the liberal-republican tradition: rival projects each claim the mantle of liberalism to define who c...

Termination-Dependent Surface States and Magnetic Fingerprints of Chiral Helimagnet Cr1/3TaS2

Abstract Chiral helimagnets based on intercalated transition-metal dichalcogenides, characterized by nanoscale spin ordering, provide a powerful route to engineer chiral spin textures (e.g., the topologically protected magnetic solitons) and explore emergent electronic functional...

Heterogeneous urban decarbonization pathways revealed by typological and machine learning frameworks: A global analysis across Annex I cities

Cities are central to global climate mitigation, yet existing projections often rely on coarse-grained assessment models that overlook the interplay between urban typology and socioeconomic dynamics. Here, we harness a context-aware deep learning framework combined with typologic...

Bayesian mixture modeling using a mixture of finite mixtures with normalized inverse Gaussian weights

In Bayesian inference for mixture models with an unknown number of components, a finite mixture model is usually employed that assumes prior distributions for mixing weights and the number of components. This model is called a mixture of finite mixtures (MFM). As a prior distribu...

Perioperative Durvalumab for Resectable NSCLC : Updated Outcomes for Japanese Patients in AEGEAN

ABSTRACT In the phase 3 AEGEAN study, perioperative durvalumab plus neoadjuvant chemotherapy significantly improved the primary endpoints of event‐free survival (EFS) and pathological complete response (pCR) in patients with resectable NSCLC versus neoadjuvant chemotherapy alone....

Aspect Ratio of Gold Nanorods Indirectly Modulates the Performance of Plasmonic‐Photochromic Fibers: A Spectroscopic Study

ABSTRACT Plasmonic‐photochromic materials have been widely investigated to harness photoresponsive properties of both components, particularly in systems comprising gold nanoparticles (AuNPs) and azobenzenes (Azos). Although AuNPs affect Azo performance, there is no information o...