Heilongjiang University of Chinese Medicine

Cross-sectional associations of insulin resistance-related indices with self-reported anxious days among U.S. adults

Anxiety is a common mental health condition that substantially impairs quality of life. Emerging evidence suggests that insulin resistance may be related to anxiety symptoms. However, the associations between commonly used insulin resistance-related indices and anxiety symptom bu...

Three traditional Chinese patent medicines combined with transarterial chemoembolization for primary liver cancer

Background: To evaluate the objective response rate (ORR) and disease control rate of 3 Chinese herbal medicines (Compound Banmao Capsule, Huaier Granule, and Jinlong Capsule) combined with transarterial chemoembolization (TACE) for primary liver cancer using Bayesian network met...

Acupuncture and Moxibustion for Neck Pain: A Clinical Practice Guideline

ABSTRACT Background Neck pain (NP) is a leading cause of disability worldwide. Pharmacological treatments often provide limited benefits and may be associated with adverse effects, highlighting the need for effective non‐pharmacological options. Aim To develop evidence‐based reco...

Smoking‐Related Distortion of Haemoglobin Concentration May Alter Anaemia Classification and Population Burden Estimates

ABSTRACT Introduction Cigarette smoking can alter interpretation of measured haemoglobin near anaemia thresholds. We quantified the consequences of applying the World Health Organization (WHO) smoking adjustment. Methods We analysed National Health and Nutrition Examination Surve...

Differences in weight loss practices and perceptions between medalists and non-medalists in national-level adolescent Sanda athletes

Objectives This study aimed to compare weight loss (WL) practices and perceptions between medalists and non-medalists among Chinese national-level adolescent Sanda athletes. Methods A cross-sectional survey was conducted among national-level adolescent Sanda athletes using the Ra...

Metabolism-Gated Cell Death Switching in Myocardial Ischemia-Reperfusion Injury: From Regulated Death Networks to Precision Cardioprotection

Myocardial ischemia–reperfusion injury (MIRI) is driven by dynamic metabolic disturbances that extend beyond adenosine triphosphate depletion and encompass mitochondrial dysfunction, redox imbalance, calcium overload, iron dysregulation, lipid peroxidation, and inflammatory activ...

Dietary patterns across the continuum of age-related cognitive decline: a scoping review

Cognitive impairment (CI) represents a progressive syndrome along the continuum from subjective cognitive decline (SCD) to dementia, with no curative treatment available. Dietary patterns, as a modifiable factor, have been linked to a slower rate of cognitive deterioration. This...

Histone Post-Translational Modifications at the Metabolism–Chromatin Interface: Reprogramming of Neuroinflammation in Alzheimer’s Disease

Increasing evidence implicates histone post-translational modifications in the persistence of neuroinflammation in Alzheimer’s disease (AD), yet how transient pathological insults are converted into sustained immune states remains unclear. In this Review, we examine histone PTMs...

Secondhand smoke exposure in never-smokers

Chronic kidney disease (CKD) is a major global health burden, yet the association of secondhand smoke (SHS) exposure with CKD among never-smokers remains incompletely characterized. This cross-sectional and prospective cohort study analyzed 13,276 never-smoking adults from the Na...

Targeting Metabolic Pathways to Direct T-Cell Trafficking: Therapeutic Perspectives

Despite advances in immunomodulatory therapies, dysregulated T-cell trafficking persists as a pathological cornerstone in chronic inflammation, autoimmunity, and cancer. This spatially precise navigation—orchestrated by receptor–ligand cascades—ensures immune surveillance but dri...

Multi-omics analysis reveals TCA cycle and mitochondrial metabolic remodeling associated with astragaloside IV-mediated cardioprotection

Diabetic cardiomyopathy (DCM) is a major complication of diabetes and is closely related to metabolic dysfunction. Astragaloside IV (ASIV), as an effective component of Astragalus membranaceus (Fisch.) Bunge, which is both edible and medicinal, plays an important role in the prev...

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis. Clinically, RA manifests as joint pain, swelling, and functional impairment caused by persistent synovial inflammation. Additionally, RA can involve vital organs, inc...

Integrated Systems Toxicology Analysis and Molecular Dynamics Study Reveal the Potential Mechanism by which Benzo[a]pyrene Contributes to Depression in Lung Adenocarcinoma via RNASE1 Upregulation

Abstract Benzo[a]pyrene (Bap), a prominent carcinogen found in tobacco smoke and air pollution, is closely associated with lung adenocarcinoma (LUAD) and subsequent depression, though the mechanism underlying this comorbidity remains unclear. LUAD patients were categorized based...

The Mechano-Immune-Vascular Activation Loop: An Integrative Conceptual Framework for Positive Feedback in Hypertension

Hypertension is increasingly recognized as involving chronic inflammation beyond its hemodynamic origins. This review proposes the Mechano-Immune-Vascular Activation Loop as an integrative conceptual framework—a positive feedback circuit in which aberrant mechanical forces in the...

Mitochondrial Homeostasis in Trabecular Meshwork Cells: A Potential Mechanism in Glaucoma

Glaucoma is the second leading cause of blindness worldwide, with its core pathological basis being impaired aqueous humor outflow and elevated intraocular pressure due to trabecular meshwork (TM) dysfunction. The structural and functional stability of the TM largely depends on t...

Eating-timing patterns derived from K-means clustering and mortality risk in US adults with chronic diseases: a cohort study

Abstract Whether joint eating-timing configurations show comparable mortality associations across chronic diseases is uncertain. We analysed 26 712 adults aged 20 years or older from the National Health and Nutrition Examination Survey (NHANES) 2005–2016 who had two reliable 24-h...

Study on Berberine/Glycyrrhizic Acid Monoammonium Salt Self-Assembled Hydrogel for Diabetic Wound Healing

Diabetic chronic wounds face multiple intractable healing obstacles including sustained inflammation, severe infection, insufficient angiogenesis and defective collagen deposition. Current dressings fail to simultaneously relieve all these pathological defects. Herein, we constru...

Mitochondria-ER contact sites in neurodegeneration: a homeostatic hub linking metabolic stress, neuroinflammation, and therapeutic opportunities

Neurodegenerative diseases (NDDs) involve self-amplifying interactions among proteotoxic stress, mitochondrial dysfunction, and neuroinflammation. Emerging evidence increasingly implicates mitochondria-endoplasmic reticulum contact sites (MERCs) as dynamic homeostatic hubs that m...

Robot-assisted biopsy a bibliometric analysis of global trends, hotspots, and emerging frontiers (2000–2025)

Robot-assisted biopsy techniques achieve precise minimally invasive sampling of deep-seated and anatomically complex lesions through stable robotic manipulation, intelligent path planning, and multimodal imaging fusion. These techniques have accumulated substantial evidence in ur...

Lactate as a Master Regulator of Immune Suppression: From Metabolic Waste to Epigenetic Checkpoint in Colorectal Cancer

Colorectal cancer, especially the microsatellite-stable subtype, which accounts for 85% to 95% of cases, resists immune checkpoint inhibitors largely due to metabolic reprogramming in the tumor microenvironment. Lactate has evolved from a waste product into a central immunosuppre...