Gunma University

Visual Search Behavior Towards Reference Areas During an S-Curve Driving Task in Elderly Drivers with Mild Cognitive Impairment

Age- and cognitive-related changes in visual search behavior may affect driving performance, particularly during complex road maneuvers requiring continuous steering adjustments. The aim of this study was to clarify the characteristics of visual search behavior in elderly drivers...

From Molecular Cages to Functional Devices: Silsesquioxane Hybrid Platforms for Next-Generation Electronic Materials

Polyhedral oligomeric silsesquioxanes (POSS) and related silsesquioxanes provide an atomically precise platform for organic–inorganic hybrid electronics. Existing reviews mainly address synthesis, functionalisation, and application breadth; comparatively few connect molecular arc...

Intraoperative protamine-induced anaphylaxis suggesting the possible involvement of an immunoglobulin E-dependent pathway based on basophil activation tests: a case report

Abstract Background Protamine is a recognized cause of perioperative anaphylaxis; however, its underlying mechanism remains incompletely understood. We report a case of protamine-induced anaphylaxis, in which skin testing and basophil activation tests (BATs) suggested the possibl...

Association Between Pre-Frailty and Falls Among Community-Dwelling Older Adults: A Cross-Sectional Study Comparing Pre-Frail and Robust Older Adults

Background/Objectives: Pre-frailty may represent an important stage for fall prevention before the development of frailty; however, its association with falls, particularly in comparison with robust status, remains insufficiently understood. In this cross-sectional study, we aime...

The elongation of Mest transcript into MestXL sustains, but does not initiate, the maternal allele bias of its convergent gene Copg2 during neurogenesis

Abstract Precise gene dosage control is critical for cellular identity and development, particularly for imprinted genes, where dosage imbalances are linked to neurodevelopmental disorders. The Mest/Copg2 imprinted locus exemplifies this fine-tuned regulation: while Mest is const...

Osteoclastogenesis with FN1-associated cell differentiation, immune communication, and ECM remodeling in male SAMP6 mice

Early diagnosis and precise treatment of senile osteoporosis remain challenging. Herein, we apply a multi-omics strategy, integrating scRNA-seq and proteomics in the male 5-month-old senescence-accelerated mouse prone 6 (SAMP6) spontaneous aging model, to study early bone loss. T...

Anterior Cruciate Ligament Injuries With Segond Fractures Are Associated With Lateral Meniscus Oblique Radial Tears and Residual Rotational Instability but Not Anatomic Internal Tibial Rotation, Compared With Those Without Segond Fractures

Purpose To investigate whether anterior cruciate ligament (ACL)‐injured knees with Segond fractures are associated with anatomic tibial rotation, increased lateral meniscus tears, and residual rotational instability. Methods This retrospective cohort study included patients who u...

Depth-resolved dose estimation in cellulose via pyrolysis for low-energy electron-beam processing

Abstract We propose a new method for estimating dose distribution in cellulose-based materials exposed to electron beams. The technique leverages the dose-dependent pyrolysis behavior of cellulose to directly quantify the absorbed dose. Using this method, we successfully estimate...

Selenium-Rich Conjugated Polymer Additives Enable Enhanced Stability in Perovskite Solar Cells

Abstract Perovskite solar cells (PSCs) have garnered significant attention in recent years due to their remarkable optoelectronic properties and the unprecedented performance gains achieved in an unprecedentedly short timeframe since their discovery. Among the various strategies...

Transition of children with chronic gastrointestinal and liver disease to adult care: A multicentre Asian survey of paediatric gastroenterologists

OBJECTIVES: The rising incidence of chronic gastrointestinal conditions and better survival of children with life-limiting diseases have resulted in the need for continuity of care into adulthood. This study aimed to detail transition practices in paediatric gastroenterology and...

Hybrid Silk Fibroin/Poly(lactic acid) Macromer Nanogels for Advanced Drug Delivery: Influence of Organic and Silsesquioxane Crosslinker Topologies on Molecular Organization and Physicochemical Properties

Abstract Molecular orientation and structural topology play critical roles in determining the performance of biomacromolecular nanocarriers for controlled drug delivery. Herein, the influence of organic and silsesquioxane crosslinker topologies on hybrid nanogels composed of an a...

16S rRNA gene amplicon sequencing data of microbial communities associated with methane concentrations in sediment microbial fuel cell systems

ABSTRACT Sediment microbial fuel cells (SMFCs) were constructed using different sediments, and microbial communities were analyzed by 16S rRNA gene amplicon sequencing. Methane concentrations were lower in roadside ditch sediment under SMFC conditions than under control condition...

From educational seminars to interpersonal diffusion: knowledge fidelity in word-of-mouth transmission of HPV vaccine information in Japan—a real-world implementation study

Abstract Background In vaccine-hesitant environments, evidence-based health information often spreads through interpersonal word-of-mouth communication within community networks. However, little empirical evidence exists regarding whether health knowledge remains accurate as it i...

Double vertebral arteries associated with a persistent primitive lateral basilovertebral anastomosis: A rare embryological configuration

Vertebrobasilar vascular anomalies arise from disturbances during the embryological development of the longitudinal neural arteries (LNAs), the proatlantal artery of Padget–Arey (ProA), and the primitive lateral basilovertebral anastomosis (PLBA) [ 1 , 2 ]. We report a rare verte...

METTL18 is Required for Developmental, Metabolic, and Endocrine Regulation of Mammalian Growth

ABSTRACT Histidine methylation is an evolutionarily conserved but poorly understood post‐translational modification. METTL18 is known to catalyze histidine N τ‐methylation in vitro, yet its physiological functions in mammals remain unclear. Here we show that mouse METTL18 possess...

Boundedness of Composition Operators in Orlicz–Morrey Spaces

ABSTRACT In this paper, we investigate the necessary and sufficient conditions for the boundedness of composition operators on Orlicz–Morrey spaces. Our results encompass Lebesgue and generalized Morrey spaces as special cases. In addition, we characterize the boundedness of comp...

P1.100. Impact of Immunotherapy Introduction on Real-World Treatment Patterns for Advanced Esophageal Cancer: A Retrospective Database Cohort Study From Japan

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background Treatment of advanced esophageal cancer (EC) has evolved with immune checkpoint inhibitors (ICIs), including nivolumab or pembrolizumab plus doublet chemotherapy (IO-chemo) and nivolumab plus ipilimumab...

P1.143. Effectiveness of 3-Months of Home Enteral Nutrition After Esophagectomy for Esophageal Cancer

Abstract Topic Esophageal Cancer: Other Background After esophagectomy for esophageal cancer, postoperative weight loss and sarcopenia are common and associated with poor prognosis. Although enteral nutrition is recommended when oral intake is insufficient, the effectiveness and...

Predictive Value of [−2]proPSA‐Related Indices for Prostate Cancer Detection Years Before Prostate‐Specific Antigen Elevation: Insights From a Five‐Year Longitudinal Screening Cohort

BACKGROUND: [-2]proPSA(p2PSA)-related indices have demonstrated diagnostic value for detecting prostate cancer (PC) in males with modest increases in prostate-specific antigen levels (PSA) of < 10 ng/mL. However, the "leak point" of p2PSA level in the blood circulation before dev...

Impact of Histopathological Response on Outcomes After Surgical Resection Following Carbon‐Ion Radiotherapy for Pancreatic Cancer With Arterial Involvement

ABSTRACT Aim Carbon‐ion radiotherapy (CIRT) provides superior dose distribution and higher biological effectiveness than conventional X‐ray radiotherapy and has emerged as a promising component of multidisciplinary treatment for advanced pancreatic ductal adenocarcinoma (PDAC). H...