Guilin Medical University

Oxygen-vacancy-rich LDH sonosensitizers potentiate narrow-spectrum antibiotics via membrane-disruption strategy for mixed bacterial wound infections

Mixed bacterial infections, including Gram-positive and Gram-negative pathogens, remain a major global health concern. Achieving efficient treatment of synergistic polymicrobial infections stills a tremendous clinical challenge due to antibiotic permeability barriers and resistan...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Latent profiles of mental health literacy and associated factors among older adults with cataracts

Abstract Mental health literacy may shape how older adults with cataracts recognize psychological distress and seek support, but variation within this population remains poorly understood. This cross-sectional study surveyed 209 hospitalized adults aged 60 years or older with cat...

Mogroside V attenuates inflammatory responses by modulating the miR-448-3p/ELL2/PDE4A axis in vitro

Various studies have revealed that natural compounds exert their bioactivities through regulation some miRNA expression. Our previous work demonstrated that Mogroside V (MV) exerts anti-inflammatory effects by downregulating miR-21-5p in LPS-stimulated RAW264.7 macrophages. Our m...

When does sequence order matter? An information-theoretic taxonomy of biological representation tasks and the limits of local encoding

Biological sequence models range from amino acid composition and k-mer counters to convolutional networks and billion-parameter language models. When is a local representation sufficient, and when is global order indispensable? This closing paper of an eight-part series answers t...

Operating room spatial layout, capacity utilization, and resource efficiency: evidence from a tertiary hospital in China

Purpose Operating rooms (ORs) are among the most resource-intensive hospital units. This study examines how OR spatial layout influences surgical preparation time, staff movement, equipment utilization, patient flow, and OR utilization in a large tertiary hospital in China. Desig...

Spectral Kakutani–Feldman–Hájek Criticality of Correlated Conformational Modes: Mode Amplitude Perturbation, Iso-Spectral Givens Rotation, and Tail-Increment Finite-Size Elimination

This is the third paper of the series "Statistical Pharmacology via Kakutani Dichotomy". Paper II (DOI 10.5281/zenodo.23012217) decomposed the covariance part of the correlated Kakutani index of two Gaussian conformational ensembles into a commuting amplitude part and a non-commu...

Statistical Pharmacology via Kakutani Dichotomy IV: KMS Inverse-Temperature Criticality β_c = 1, Pocket-to-Distal Tail Allostery, and the Four-Quadrant Ligand Classification

This is the fourth paper of the series Statistical Pharmacology via Kakutani Dichotomy, which transports the tail-event phase transition of Localized Bost–Connes systems (R. Chen, DOI 10.5281/zenodo.22883179) to the statistical geometry of protein conformational ensembles. Papers...

When does sequence order matter? An information-theoretic taxonomy of biological representation tasks and the limits of local encoding

Biological sequence models range from amino acid composition and k-mer counters to convolutional networks and billion-parameter language models. When is a local representation sufficient, and when is global order indispensable? This closing paper of an eight-part series answers t...

FibreBench: stress-testing protein sequence encoders against exact combinatorial spectral invariants

Protein representation models are usually evaluated on test sets split by sequence identity. Such splits cannot reveal what an architecture is unable to distinguish by construction. FibreBench is a benchmark built from an exact invariant instead. Each test pair consists of a huma...

Phenotypic insufficiency of local protein representations: fibre-preserving rearrangements of human C2H2 zinc-finger arrays reorder DNA-recognition residues under an invariant 25-spectrum

A protein representation built from local sequence statistics assigns the same vector to all sequences with the same multiset of k-mers, the spectral fibre. Whether this blind spot matters depends on the phenotype. For C2H2 zinc-finger proteins, whose fingers read DNA in order, i...

Associations Between Kidney Function and Risk of Cognitive Impairment Among Chinese Older Adults

ABSTRACT Background The association between kidney function and dementia remains inconsistent across studies, and its relationship in older adults is unclear. This study aimed to investigate the longitudinal associations between kidney dysfunction, assessed by estimated glomerula...

Symmetry-constrained spectral fibres: reverse-complement group actions on double-stranded DNA and the fibres of circular molecular fingerprints

A representation that depends on an object only through its local content is constant on the object's spectral fibre, the set of objects with the same multiset of local pieces. This paper treats two settings in which a symmetry enters. Double-stranded DNA. Reverse complementation...

Biologically reachable spectral fibres: repeat shuffling, copy ambiguity and the scarcity of cryptic pathogenic missense variants in ClinVar

A protein sequence encoder that depends only on k-mer statistics is blind to the rearrangements that preserve them: the spectral fibre of the protein. Most members of a fibre are not proteins that evolution or disease could produce. We ask which part of the fibre is biologically...

Biologically reachable spectral fibres: repeat shuffling, copy ambiguity and the scarcity of cryptic pathogenic missense variants in ClinVar

A protein sequence encoder that depends only on k-mer statistics is blind to the rearrangements that preserve them: the spectral fibre of the protein. Most members of a fibre are not proteins that evolution or disease could produce. We ask which part of the fibre is biologically...

Artificial Intelligence-Driven Real-Time Restoration of a Cultural Heritage Analog Digital Twin Model

The preservation of cultural heritage structures is increasingly challenged by environmental degradation, aging, and human activities. This study presents an artificial intelligence (AI)-driven framework for real-time monitoring, crack detection, and restoration planning within a...

Depression and anxiety mediate the association between sleep quality and health-related quality of life in people living with HIV

Sleep disturbances are highly prevalent among people living with HIV (PWH) and frequently co-occur with psychiatric comorbidities such as depression and anxiety. Although these factors independently predict health-related quality of life (HRQoL), the extent to which psychiatric s...

Kummerowia striata extract ameliorates polycystic ovary syndrome and associated hepatic metabolic dysfunction in mice: an integrated network-pharmacology and lipidomics study of the HIF-1α signaling axis

Context Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder in women of reproductive age and a major contributor to infertility. Kummerowia striata (Ks) is a plant of medicinal and dietary significance. Although its extract has demonstrated beneficial...

Prediction of low oocyte retrieval in young women undergoing IVF/ICSI: a multicenter external validation study

Abstract Objective To externally validate a previously developed pretreatment prediction nomogram for identifying young women at risk of low oocyte retrieval (LOR). Methods This multicenter retrospective study included 14,702 women aged ≤ 35 years undergoing their first in vitro...

Preclinical toxicity and immunogenicity of a quadrivalent recombinant influenza hemagglutinin vaccine (SCVC101) in rhesus monkeys

SCVC101 is a novel recombinant hemagglutinin (rHA) protein-based quadrivalent seasonal influenza vaccine containing HA gene sequences of A/Wisconsin/588/2019 (H1N1) pdm09-like virus, A/Cambodia/e0826360/2020 (H3N2)-like virus, B/Washington/02/2019 (B/Victoria lineage)-like virus,...