Guilin Medical University

Aptamer-functionalized exosomes co-delivering miR-934 inhibitor and gemcitabine for targeted pancreatic cancer therapy

Pancreatic cancer remains a malignancy with limited treatment efficacy and high resistance to chemotherapy. miR-934 was identified as an oncogenic miRNA significantly upregulated in pancreatic cancer, promoting tumor progression, epithelial-mesenchymal transition (EMT), and chemo...

Integrative transcriptomic and machine learning analyses identify NOL7 and TXLNA as candidate blood biomarkers for Parkinson’s disease within an RNA modification-associated co-expression network

Abstract Background Parkinson’s disease (PD) pathogenesis involves complex molecular mechanisms, with emerging evidence implicating RNA modifications (RM). This study sought to explore RM-associated key genes and their roles in PD progression. Methods Transcriptomic datasets GSE6...

Additive manufacturing of advanced electronic devices: a comprehensive review of materials, processes, and applications

The additive manufacturing (AM) technology has gained recognition as an innovative technology that holds promise for transforming the electronics industry through the realization of complex designs and multi-material integration. Advances in additive manufacturing (AM) technologi...

Latent class analysis of sexual behavior and HIV testing profiles among sexually experienced college students in China: a cross-sectional online survey

Rising human immunodeficiency virus (HIV) infections among young people underscore the need to strengthen campus-based prevention. We used latent class analysis (LCA) to summarize sexual behavior and HIV-testing profiles among sexually experienced college students, examine associ...

BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage–fibroblast interactions to attenuate pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. Targeting macrophage polarization and fibr...

Effects of Shade Treatments on Growth, Photosynthetic Performance, Leaf Microstructure, and Pigment Accumulation in Horsfieldia hainanensis Seedlings

In this study, three-year-old seed-derived seedlings of Horsfieldia hainanensis Merr. were subjected to 0%, 25%, 50%, and 75% shade treatments in a nursery shade-net experiment from October 2025 to June 2026. Each treatment included three replicates, with three seedlings per repl...