Gladstone Institutes

P1.047. Therapeutic Endoscopy as Essential Regional Care: Outcomes From an Australian Centre

Abstract Topic Benign Disease: Other Background Providing therapeutic endoscopy in regional centres offers substantial benefits by enabling minimally invasive gastrointestinal interventions closer to home. This reduces travel burden, improves timely access to specialist care, and...

Genome folding and nuclear speckles converge to orchestrate fibroblast activation

Fibroblasts adopt diverse cell states in response to inductive cues to maintain tissue homeostasis. We leveraged this cell-state plasticity to define how genome organization contributes to changes in cellular identity. We show that TGF-β reconfigures topologically associating dom...

Human spinal interneurons repair the injured rat spinal cord through synaptic integration

Spinal cord injury (SCI) results in irreversible disruption of motor, sensory, and autonomic circuits with no approved reparative treatment to restore lost function. Endogenous V2a spinal interneurons (SpINs) have been implicated as a key component in recovery post-SCI, but the i...