Gdańsk Medical University

Routing to the seizure in postoperative human glioma cortex: spatio-temporal uncoupling between slow and fast extracellular neuronal activities

Abstract Background Diffuse gliomas are frequently associated with epilepsy, particularly in low-grade variants. Seizures are key events to be considered in glioma management, including during surgery. Optimizing resection of epileptic areas may affect not only postoperative epil...

Advanced airway management practice patterns and short-term survival in Poland’s national physician-staffed helicopter emergency medical service, 2020–2024: a retrospective observational study

Advanced prehospital airway management involves endotracheal intubation or supraglottic airway placement. Evidence on airway management and survival in combined ground EMS–HEMS care remains limited, particularly regarding technique sequence and outcomes across clinical groups. Th...

Anti-inflammatory diet as an element supporting the treatment of selected gynecological diseases — literature review

Low-grade chronic inflammation plays an important role in the pathogenesis of many gynecological diseases, including polycystic ovary syndrome (PCOS), uterine fibroids, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD) and endometriosis. The aim of this paper wa...

Evaluating cardiological rehabilitation using wavelet analysis: a pre- and post-rehabilitation comparison

Abstract Cardiac rehabilitation (CR) improves prognosis and exercise capacity, but conventional indices may not fully capture subtle changes in cardiovascular signal dynamics. Time–frequency analysis of cardiovascular signals may provide additional, candidate time–frequency featu...

Mitochondrial transcript abundance in breast cancer circulating tumour cells may reflect both blood-derived transcripts and biological heterogeneity

Circulating tumour cells (CTCs) are rare cells frequently profiled on a single cell level. A key indicator of single-cell transcriptome quality is the percentage of reads encoded by genes in the mitochondrial genome (MT-reads). No systematic data exists on MT-reads content in CTC...

Emergency abdominal surgery: variation in closure practice and early postoperative outcomes in the prospective multicentre PROPHECY study

Emergency abdominal surgery carries a high risk of postoperative morbidity, yet prospective multicentre data on real-world abdominal wall closure practices remain limited. This interim analysis of the PROPHECY study aimed primarily to characterise current abdominal wall managemen...

Achieving physiologic distensibility targets frequently requires modification of standard cruroplasty during anti-reflux surgery

Abstract Background Intraoperative EndoFLIP provides objective assessment of esophagogastric junction (EGJ) distensibility during anti-reflux surgery, and final distensibility index (DI) values of 2.0–3.5 mm 2 /mmHg have been associated with improved reflux control while minimizi...

Association of fibrotic-lung 18F-FDG uptake with GAP severity and clinical outcomes in idiopathic pulmonary fibrosis: an exploratory retrospective study

Idiopathic pulmonary fibrosis (IPF) is characterised by a variable and unpredictable clinical course. While GAP (gender, age, physiology) score remains the clinical standard for staging, it does not provide real-time insight into lesion metabolic activity. This study evaluates th...

Association of the 5-item modified frailty index and chronological age with postoperative length of stay after CRS–HIPEC: a single-centre cohort study

Frailty assessment may inform selection for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS–HIPEC), but its association with hospitalization in functionally selected patients remains uncertain. To evaluate the association of the 5-item modified frailty i...

When analgesics are not enough for postpartum perineal pain—a scoping review of the non-pharmacological, conservative therapies

Postpartum perineal pain affects up to 90% of women, with 37% reporting moderate to severe pain. Assisted delivery, episiotomy, and lacerations increase pain and medication use. Management includes pharmacological treatments like paracetamol, opioids, and non-steroidal anti-infla...

Diagnostic Accuracy of Amino Acid PET for Differentiating Tumor Recurrence or Progression from Treatment-Related Changes in Glioma Patients: A Uppstematic Review and Meta-Analysis

Background: Differentiating tumor recurrence from treatment-related changes in patients with glioma remains a major diagnostic challenge because conventional MRI has limited specificity. Amino acid positron emission tomography (PET) has emerged as a promising adjunctive imaging m...

Tobacco and nicotine product use patterns among young healthcare professionals in Poland: findings from the qualitative component of the NIKO Study

While healthcare professionals (HCPs) are in many ways the best-positioned promoters of smoking cessation, many of them use tobacco and nicotine products (TNPs), which can undermine their credibility. In this paper, we report a qualitative study undertaken to assess TNPs’ use pat...

LazypipeX: customizable virome analysis pipeline enabling fast and sensitive virus discovery from NGS data

Abstract Metagenomic next-generation sequencing (mNGS) is pivotal for detecting known and novel viruses, however, its efficacy depends on applied bioinformatics pipelines. We present Lazypipe Extended (LazypipeX), an mNGS pipeline employing modular “annotation strategies” to opti...

Long-Term Sequelae in Patients Treated for Recurrent CNS Relapses of Pediatric B-Cell Acute Lymphoblastic Leukemia: 20-Year Follow-Up, Neurological Consequences, and Survivorship Burden—A Case Report and Literature Review

Central nervous system (CNS) relapse remains a major cause of treatment failure in pediatric acute lymphoblastic leukemia (ALL). Repeated isolated CNS relapse is particularly rare and associated with poor prognosis, while optimal therapeutic strategies remain insufficiently defin...

Tobacco Industry corporate social responsibility activities in Poland in the years 2019-2024

INTRODUCTION: The tobacco industry frequently uses corporate social responsibility (CSR) activities to build relationships with stakeholders and maintain its legitimacy despite the health harms caused by its products. In Poland, where direct tobacco advertising is prohibited, CSR...

Targeting C4d to overcome resistance to antibody-based immunotherapy: an in vitro study

Tumor cells often develop defense mechanisms that render them insensitive to consecutive administrations of therapeutic monoclonal antibodies. This study aimed to produce an antibody that preferentially binds resistant tumor cells and eliminates them by the complement system atta...

Autophagy-associated marker and stress-response changes in ASA- and 5-FU-treated 3D colorectal cancer spheroid models exposed to 3-MA or CQ

Abstract Autophagy-associated pathways are implicated in colorectal cancer (CRC) progression and therapy resistance. CRC is among the most frequently diagnosed malignancies worldwide and remains a major challenge in oncology due to its complex therapeutic management. We evaluated...

Nipple-Areola Complex Reinnervation Using Intercostal Nerve Grafts in Implant-Based Reconstruction.

Despite successful aesthetic outcomes, immediate breast reconstruction is frequently accompanied by significant sensory loss, compromising patient quality of life. While neurotization techniques are established for autologous flaps, a standardized solution for implant-based recon...

Integrated in silico and experimental analysis of a stress-responsive DOXC21-A natural antisense transcript suggests small RNA-associated regulation in Arabidopsis thaliana

Abstract Background Natural antisense transcripts (NATs) represent an important regulatory layer that can modulate gene expression in plants. However, their functional relevance at specific stress-responsive loci and evolutionary emergence remain poorly characterized. The DOXC21...

Exploratory Insights into 5-MeO-DMT Experiences on Reddit: A Thematic Analysis

This qualitative study examines self-reported experiences with 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) shared on Reddit to explore subjective reports, contextual influences, and perceived effects. A total of 120 posts from 24 discussion threads were purposively selected and...