Gansu Provincial Hospital

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Single-Cell and Spatial Transcriptomics Reveal CHCHD3 as a Therapeutic Target to Activate cGAS-STING and Overcome Immunosuppression in Lung Adenocarcinoma

Abstract A substantial proportion of treatment-naive lung adenocarcinoma (LUAD) patients exhibit intrinsic resistance to neoadjuvant chemoimmunotherapy, highlighting the need for mechanism-driven therapeutic strategies. Here, we performed integrated single-cell RNA sequencing (sc...

Effectiveness and implementation of task-sharing cognitive-behavioral interventions for perinatal mental health: Protocol for a systematic review and meta-analyses

Cognitive behavioural interventions (CBIs) delivered by nonspecialist providers (NSPs) offer a scalable strategy to address the global mental health workforce gap, enhancing access to evidence-based care for perinatal depression and anxiety. The objective of this systematic revie...

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind, placebo-controlled trial at...

Operating room spatial layout, capacity utilization, and resource efficiency: evidence from a tertiary hospital in China

Purpose Operating rooms (ORs) are among the most resource-intensive hospital units. This study examines how OR spatial layout influences surgical preparation time, staff movement, equipment utilization, patient flow, and OR utilization in a large tertiary hospital in China. Desig...

Peripheral blood tumor aberrantly glycosylated proteins are associated with disease progression in lung cancer

This study investigated tumor aberrantly glycosylated proteins (TAGPs) as a novel serum biomarker for lung cancer. By analyzing their associations with clinicopathological features and conventional markers, we evaluated the diagnostic efficacy of TAGPs in discriminating lung canc...

Rethinking ovarian cancer early detection: risk-adapted strategies, diagnostic pathways, and emerging biomarkers

Ovarian cancer early detection remains a major challenge because most patients present with advanced disease, whereas population-wide screening in average-risk women has not shown a clear mortality benefit. This narrative review examines how early detection should be redefined in...

Frailty and bone quality as the predictors of mechanical complications for patients after lumbar interbody fusion: a retrospective cohort study

Mechanical complications following lumbar interbody fusion are common in in elderly patients, particularly those with compromised bone quality. The MRI-based vertebral bone quality (VBQ) score assesses bone quality, while the modified frailty index (mFI) captures systemic physiol...

Human Umbilical Cord Mesenchymal Stem Cells Enhance Folliculogenesis and Fertility in Premature Ovarian Failure Mice via Regulating Steroid synthesis

Abstract Background Premature Ovarian Failure (POF) is a dysfunction that severely impacts women's physiological health and reproductive function. Human umbilical cord mesenchymal stem cell (hUCMSC) transplantation offers a promising therapeutic option for restoring ovarian funct...

Development of a symptom cluster scale for breast cancer patients undergoing adjuvant chemotherapy based on the Chinese population: a Delphi-based study

Breast cancer is the most common malignancy among women in China.Postoperative adjuvant chemotherapy can reduce the risk of recurrence, but it can also give rise to complex symptom clusters that significantly affect patients’ quality of life and treatment adherence. Currently, sp...

Admission low-density lipoprotein cholesterol and early haematoma expansion after spontaneous intracerebral haemorrhage

Background The association between low-density lipoprotein cholesterol (LDL-C) and haematoma expansion (HE) after spontaneous intracerebral haemorrhage (ICH) remains uncertain. This study evaluated whether admission LDL-C was independently associated with early HE and whether it...

Integrated Multi-Omics Analysis Reveals Candidate Serum Biomarkers Linked to Cancer-Associated Fibroblast-Mediated Extracellular Matrix Remodeling in Metastatic Gastric Cancer

Abstract Metastatic gastric cancer remains a major cause of cancer-related mortality, while currently available serum biomarkers have limited performance for metastatic risk assessment. This study aimed to identify candidate serum biomarkers associated with gastric cancer progres...

Primary hypertrophic osteoarthropathy with anemia as assessed by 18F-FDG PET/CT.

F-FDG) positron emission tomography/computed tomography (PET/CT) imaging revealed a constellation of findings that can be grouped into three categories: (1) skeletal: cortical thickening and periosteal reaction in the long bones of the lower limbs, along with extensively increase...

SPECT/CT confirms metastatic pulmonary calcification on bone scintigraphy: Directing management in a dialysis patient

We report a case of metastatic pulmonary calcification diagnosed by 99m Tc-MDP bone scintigraphy with SPECT/CT in a 52-year-old man with end-stage renal disease on hemodialysis. The patient presented with bone pain and mild cough, and had severe biochemical derangements of chroni...

Beyond the Clock: Reprogramming Fertility in Diminished Ovarian Reserve

Diminished Ovarian Reserve (DOR) is a significant manifestation of female reproductive aging that profoundly impacts fertility and quality of life. In recent years, the emergence of aging reprogramming technologies has provided new insights into the mechanisms underlying DOR and...

Research Progress of Autophagy and Ferroptosis in Endometriosis.

to clarify the mechanisms of autophagy，ferroptosis，and their interaction in the occurrence and progression of EMs can not only delve into the invasion and migration processes of ectopic lesions in the pelvis and abdomen but also provide new ideas and targets for the treatment o...

One vs twelve month aspirin after percutaneous coronary intervention for acute myocardial infarction: individual patient-data analysis of TARGET-FIRST and ULTIMATE-DAPT trials

Giuseppe Tarantini, Xiaojuan Zhang, Luca Nai Fovino, Jing Kan, Zhen Ge, Guillaume Cayla, Pieter C Smits, Benjamin Honton, Valeria Paradies, Yann Poezevara,

Integrated proteomic and metabolomic analysis identifies complement activation and metabolic alterations in the serum of patients with idiopathic membranous nephropathy: an exploratory study

Idiopathic membranous nephropathy (IMN) is a common cause of nephrotic syndrome in adults, yet its pathogenesis remains incompletely understood. This exploratory study aimed to characterize serum molecular profiles in IMN patients by integrating proteomics and metabolomics analys...

Recurrent intraoperative asystole induced by tumor manipulation in a cervical vagal schwannoma: a case report

<title>Abstract</title> <bold>Background:</bold> Vagal schwannomas are rare, benign tumors arising from Schwann cells of the vagus nerve. Surgical resection is the mainstay of treatment but carries significant risks, including intraoperative hemodynamic instability due to vagal n...

An improved inverse method for estimating disease transmission rates in epidemics with low-incidence data

Abstract The accurate estimation of time-varying transmission rates is fundamental for understanding infectious disease dynamics and implementing effective public health interventions. To this end, we propose an improved inverse method for estimating time-varying transmission rat...