Friedrich Schiller University Jena

Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic

ABSTRACT Polymyxins are potent nonribosomal peptide antibiotics, yet their clinical use is limited by a narrow therapeutic window and nephro‐/neurotoxicity. Conventional efforts to improve these agents rely on the incorporation of nonnatural building blocks that cannot be accesse...

Molecular divergence and genomic composition of B chromosomes in the fish Cyphocharax modestus (Characiformes, Curimatidae)

Abstract B chromosomes are supernumerary elements that evolve from standard A chromosomes and are primarily composed of repetitive DNAs, yet their origin, diversification, and molecular composition remain poorly understood in most vertebrates. We investigated two allopatric popul...

Activation-independent capture of free fatty acids at the bacterial cell envelope by BrtB

ABSTRACT Fatty acids (FAs) are key metabolites in living organisms, shaping membrane architecture, and helping cellular acclimatization to changing conditions. Bacteria synthesize FAs de novo but can also reclaim them from membrane lipids or uptake them from the environment, usua...

Bottom-Up Realization of a Type-II Organic/Transition-Metal Dichalcogenides Heterointerface: Pentacene on Monolayer WS2

Abstract Stacked van der Waals heterostructures based on transition-metal dichalcogenides (TMDs) exhibit a rich variety of exotic interfacial phenomena. Substituting one component with an organic semiconductor (OSC) enables the design of hybrid heterostructures with tunable funct...

Spin Crossover in an Iron(II) Complex with a Radical Iminosemiquinonate Ligand

Abstract Metal complexes that exhibit spin crossover (SCO) or valence tautomerism (VT) are promising candidates for molecular materials. In an exploration of the interplay between SCO and VT in iron chemistry, we combined redox-active aminophenol derivatives (4,6-di-tert-butylphe...

Large-scale benchmarking of prokaryotic annotation tools across thousands of species

Abstract Background Genome annotation is an important step in deriving functional meaning from prokaryotic sequencing data, yet systematic evaluations guiding tool selection are lacking. We present the first large-scale investigation of four prominent open-source annotation tools...

Current and Future Directions for Responsible Quantum Technologies: A ResQT Community Perspective

Abstract Quantum technologies (QT) are advancing rapidly, promising advancements across a wide spectrum of applications but also raising significant ethical, societal, and geopolitical impacts, including dual-use capabilities, varying levels of access, and impending quantum divid...

Enhancement of Circular Dichroism in Chiral Dielectric Metasurfaces by Ion Beam Irradiation

ABSTRACT Resonant chiral dielectric metasurfaces can support circular dichroism exceeding that of natural materials, but their small dissipative losses simultaneously limit the maximization of circular dichroism, which inherently relies on absorption. Importantly, while the condi...

Exponentiation of higher-point and higher-genus Virasoro conformal blocks in the semiclassical limit

A bstract A long-standing conjecture claims that Virasoro conformal blocks exponentiate in the semiclassical limit c → ∞ with h / c finite. However, this has been proven only for four-point blocks on the sphere and one-point blocks on the torus. Here we extend the proof to genera...

A Ni(II) PNP pincer complex immobilized on SBA-15 as catalyst for the 4-nitrophenol hydrogenation

Abstract The Ni(II) complex [NiCl(bda)]+ containing the aliphatic PNP pincer ligand bis((2-diphenylphosphino)ethyl)amine (bda) was covalently immobilized on the mesoporous silica SBA-15. SBA-15 was functionalized with (3-chloropropyl)triethoxysilane as an anchoring agent, which w...

The role of general practitioners in German cancer care: a scoping review

Abstract Background General practitioners (GPs) play an important role in the care of patients with cancer across the entire cancer continuum, from diagnosis to palliative care. Despite their broad range of responsibilities, structures to facilitate the systematic involvement of...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

Insights Into the Nature of Quantum Emitters in Electron‐Irradiated Hexagonal Boron Nitride

ABSTRACT Quantum emitters in hexagonal boron nitride (hBN) have emerged as a promising solid‐state platform for quantum technology applications. However, a persistent challenge in the field is the unclear origin of many observed emission lines, particularly in the visible range,...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

Host‐to‐Pathogen Transfer of Neutrophil Components via Extracellular Vesicles Shields Candida albicans From Immune Attack in Human Blood

ABSTRACT Neutrophils effectively eliminate Candida albicans from human blood, but a subset of fungal cells escapes clearance and remains extracellular and viable. Here we show that this evasion is independent of known immune‐escape traits of C. albicans . Instead, neutrophil‐deri...

Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (nHCM) is associated with significant morbidity with no approved treatment. Aficamten is a cardiac myosin inhibitor targeting excess contractility and diastolic impairment, the predominant mechanism responsible for adverse ou...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

Simple birth-death-mutation models predict some—but not all—aspects of the experimental evolution of antibiotic resistance

Mathematical modelling of antibiotic resistance plays an important role in understanding the mechanisms of resistance emergence and spreading, testing the feasibility of new treatment protocols, and antimicrobial stewardship. However, many assumptions underlying some of the most...

Catalytic non-energetic formation of diverse peptides on cosmic dust under extraterrestrial conditions

Abstract This study experimentally examines a non-energetic pathway for peptide formation under realistic space conditions. Unlike radiation-driven processes, this mechanism involves low- or zero-barrier reactions at cryogenic temperatures. This provides a less stochastic chemica...

The Parameter Report: An Orientation Guide for Data-Driven Parameterization

A strength of parameterized algorithmics is that each problem can be parameterized by an essentially inexhaustible set of parameters. Usually, the choice of the considered parameter is informed by the theoretical relations between parameters with the general goal of achieving FPT...