Florida College

Beta-Lactam Dose Optimization Using Therapeutic Drug Monitoring in Pediatric Patients

OBJECTIVE: Beta-lactam therapeutic drug monitoring (BL-TDM) is underused in pediatric patients where drug exposure is highly variable. This study evaluated the pharmacokinetic/pharmacodynamic (PK/PD) target attainment of BLs in pediatrics. PATIENTS AND METHODS: A retrospective ob...

International consensus guidance for general population screening for islet autoantibodies to diagnose early-stage type 1 diabetes: a nominal group technique process

Type 1 diabetes is an autoimmune disease that targets and destroys insulin-producing beta cells in the pancreatic islets. The incidence of type 1 diabetes is rising globally. At the clinical diagnosis of type 1 diabetes, between 20% and 67% of children and adolescents present wit...

Assessing the impact of a gender-neutral approach to HPV vaccination on vaccination coverage for nine-year-old girls in Cameroon: A retrospective, cross-sectional study

Cameroon introduced the human papilloma virus vaccine (HPVV) into the routine immunization schedule in October 2020. By the end of 2022, coverage remained low. To increase coverage, Cameroon switched to a country-wide, gender-neutral vaccination (GNV) approach in 2023, coupled wi...

Chemisorbed Oxygen Enables a Bicarbonate-Mediated Pathway for Formic Acid Oxidation on IrO2(110)

Abstract Understanding the mechanisms for formic acid oxidation on transition-metal oxides is essential for designing catalysts with improved activity and resistance to CO poisoning. Here, we investigated how chemisorbed oxygen (Ot) influences formic acid oxidation on IrO2(110) u...

Associations Between Parental Beliefs About Their Child’s Weight Controllability, Negative Weight Comments, and Initiation of Weight Talk with Children

Background: Negative parental weight talk is associated with adverse outcomes in youth. Weight controllability beliefs are linked to weight stigma, but it is unknown whether parents’ general beliefs about one’s control over their weight (general weight controllability beliefs), o...

Exogenous lipoid pneumonia from chronic mineral oil aspiration complicated by cavitary Mycobacterium abscessus infection

Lipoid pneumonia is a rare inflammatory lung disease that results from the accumulation of lipids within the alveoli. It is classified as either exogenous or endogenous based on the source of the lipid material. Endogenous lipoid pneumonia commonly occurs in inflammatory lung dis...

Institutional phronesis: theorizing how US primary care clinicians navigate competing incommensurate logics of efficiency, care, and market in clinical practice

In the highly privatized United States primary care environment, physicians must attend to incommensurate logics of quality care. That is, they must attempt to holistically care for patients within a system that has been described as highly commodified and bureaucratically violen...

Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change

ABSTRACT Background We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior. Methods We developed and distribut...

Distinguishing Benign from Malignant Small Enhancing Breast Lesions Using Radiomics

Background/Objectives: Small enhancing lesions (often termed foci if lesion ≤ 5 mm) observed on breast magnetic resonance imaging (MRI) pose a persistent challenge. Their clinical relevance and the most effective management strategy remain unclear, often leading to unnecessary bi...

The Cardiac “Flip” Sign: A Simple Sonographic Marker for “Mirror Image Configuration” of the Great Arteries

ABSTRACT We hereby describe a new sonographic sign, the cardiac “flip” sign, to help in the prenatal detection of a right sided aortic arch with a right sided ductus arteriosus. This sign depends on pattern recognition where the sonologist/sonographer needs to obtain a cardiac sw...

Likelihood‐Based Inference With Separable Correlation Matrices

ABSTRACT This paper proposes methods for likelihood‐based inference in multivariate linear regressions when the correlation matrix of the responses is separable; that is, it has a Kronecker product structure, but the variances are unrestricted. The methods are enabled by a block‐...

Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes

Abstract Aims/hypothesis Immunotherapies such as Teplizumab can preserve residual beta cell function in individuals with newly diagnosed type 1 diabetes (T1D), but treatment response is variable. Currently, no biomarker exists to identify individuals most likely to benefit from i...

MultipathwayAggregation Drives Concentration-DependentAmyloid Polymorphism and Time-Dependent Morphological Evolution

Abstract Amyloid aggregation into polymorphic fibrils is central to many neurodegenerative and systemic diseases, yet the physical origins of fibril polymorphism and time-dependent morphological evolution remain unclear. Because mature fibril morphologies are separated by high en...

Exercise and Brain Health in Postmenopausal Women: A Review of Cognitive Benefits, Mechanisms, and Neurodegeneration Prevention

Menopause represents a major neuroendocrine transition characterized by substantial hormonal, metabolic, vascular, and inflammatory changes that may increase vulnerability to cognitive decline and neurodegenerative disease. Declining estrogen levels during the menopausal transiti...

Characterizationof Dapalides D and E and GenomicComparison of the Two Co-Occurring Dapalide-Producing Dapis spp.

Abstract Marine cyanobacteria are a rich source of diverse bioactive natural products, targeting proteins involved in many diseases. Here, we combined metagenomic analysis to enhance the structure elucidation process of two new cyclodepsipeptides named dapalides D (1) and E (2) f...

Pushing theLimits of Ultrasmall PbSe Magic-SizedClusters

Abstract Ultrasmall PbSe magic-sized clusters (MSCs) are important for probing the nucleation of nanocrystals and their optical properties under strong quantum confinement. The smallest PbSe MSC observed so far in the growth sequence has an absorption maximum at 625 nm. Here, we...

Response to “Prepregnancy GLP ‐ 1 Receptor Agonist Use: Unaccounted Pretreatment BMI May Distort Obstetric Outcome Signals in Real‐World Studies”

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Radiological Late Dental Adverse Effects Following Treatment for Paediatric Head and Neck Rhabdomyosarcoma: Results of a Transatlantic Multicentre Cohort Study

ABSTRACT Objectives Rhabdomyosarcoma represents the most common paediatric soft tissue sarcoma, with 40% occurring in the head and neck region. Given that survival rates now reach 80%, minimising late adverse effects, particularly dental developmental complications, has become a...

How High is the Bar? Pension Fund Benchmark Choices in Real Assets

Abstract This paper examines how defined benefit pension funds select and revise performance benchmarks for real assets, including private real estate, listed REITs, infrastructure, commodities, and natural resources. Using data from CEM Benchmarking, we document substantial hete...

Evaluating Mechanical-EmbeddingML/MM for PredictingMutation Effects in Chorismate Mutase Catalysis

Abstract Predicting how mutations alter enzyme catalysis remains a central challenge in enzymology and enzyme engineering. Although quantum mechanics/molecular mechanics (QM/MM) simulations can in principle compute the activation free energy associated with enzymatic reactions, t...