First Affiliated Hospital Zhejiang University

Early low-molecular-weight heparin versus early aspirin after off-pump coronary artery bypass: a retrospective propensity score-matched exploratory study

The optimal early antithrombotic strategy after off‑pump coronary artery bypass grafting (OPCAB) remains controversial. This single‑center retrospective propensity‑score matched study compared antithrombotic therapies initiated at postoperative 6 h. Clinical data were retrieved f...

Rapid versus slow puncture in endoscopic ultrasound-guided liver biopsy: a multicenter randomized crossover trial

Abstract Endoscopic ultrasound-guided liver biopsy (EUS-LB) is increasingly used for hepatic histologic assessment; however, optimal technical approaches remain undefined. This prospective, multicenter clinical study aimed to compare tissue acquisition and safety between the rapi...

A Dual-Functional Hydrogel Coating for Expanded Polytetrafluoroethylene Endografts with Antibacterial and Interface-Sealing Functions

Abstract Although expanded polytetrafluoroethylene (ePTFE) endografts provide excellent mechanical exclusion of aneurysm blood flow, they remain biologically inert and lack surface functions that actively prevent bacterial colonization or promote favorable graft–vessel interface...

Identification of perioperative risk factors for retrograde type A dissection after thoracic endovascular aortic repair for type B dissection

Objective To identify risk factors and develop a predictive model for retrograde type A dissection (RTAD) following thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (TBAD).Methods We analyzed TBAD patients who underwent TEVAR from 2014 to 2024 (IRB:No. TJ-...

Imaging Manifestations and Clinical Analysis of 12 Cases of Anorectal Malignant Melanoma

AIM: To investigate the computed tomography (CT) and magnetic resonance imaging (MRI) features and clinical characteristics of primary anorectal malignant melanoma (ARMM).METHODS: This retrospective analysis was conducted on the clinical, imaging and pathological data of 12 patie...

CD34+ myofibroblasts promote neointima formation in vein grafts by activating ferroptosis-induced smooth muscle cell phenotype switch

Abstract Aim Vein graft (VG) failure due to adverse remodeling and aggressive neointimal hyperplasia is a major complication and key limiting factor for maintaining long-term VG patency. CD34+ cells have been implicated in multiple cardiovascular diseases, but their functional in...

A Peripheral Sulfonium Moiety Engineering Strategy to Enhance AIEgen-Based Antitumor Photodynamic Therapy

Abstract The therapeutic efficacy of photosensitizers (PSs) strongly depends on their capacity to efficiently generate reactive oxygen species (ROS). Herein, we report a peripheral sulfonium moiety engineering strategy and identify a lead aggregation-induced emission (AIE)-based...

Photoactive Chiral Nanoneedles for Site-Selective Cleavage and Broad-Spectrum Inactivation of Viruses

Abstract Respiratory viruses spread through aerosols and contaminated surfaces, yet masks, respirators, and filters only trap pathogens without inactivating them, turning used protective equipment into a secondary transmission source. Here, we report chiral ZnO nanoneedles (L-NNs...

The glymphatic–lymphatic axis: known pathways, open questions, and emerging roles in neurodegeneration

Abstract The discovery of the glymphatic system and meningeal lymphatic vessels has transformed our understanding of brain fluid homeostasis and central–peripheral communication, highlighting the critical role of cerebrospinal fluid in brain clearance. While substantial progress...

Extracellular matrix–targeted TNC-scFv armoring enhances CAR T cell persistence and antitumor activity in solid tumors

Chimeric antigen receptor T cell (CAR T cell) therapy has shown limited efficacy in solid tumors, largely due to physical and immunosuppressive barriers imposed by the tumor microenvironment (TME). Tenascin-C (TNC), an extracellular matrix protein highly expressed in multiple sol...

New periodontal phenotype classification in patients with different types of malocclusion and dental crowding

Abstract Background The periodontal phenotype plays a critical role in periodontal stability and orthodontic risk assessment. However, an integrated evaluation of soft‐ and hard‐tissue periodontal characteristics across various sagittal and vertical skeletal patterns and dental c...

Right upper lobectomy via selective right upper lobe isolation using a left-sided double-lumen tube placed in the right bronchus intermedius: a case report

Abstract Background One-lung ventilation (OLV) using a left-sided double-lumen tube (DLT) in the left main bronchus is standard for right thoracic surgery. When the contralateral left lung is severely compromised, this approach forces OLV to rely on the dysfunctional lung and ris...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

Neddylation E2 enzyme UBE2M inhibits inflammatory lung tumor microenvironment by blocking the cGAS-STING signal upon KrasG12D activation.

activation in the lung.

Mendelian Randomization and Machine Learning for Anatomical Subtyping of Adolescent Sleep Apnea

Introduction and aims Obstructive sleep apnea (OSA) is associated with dentofacial skeletal and soft-tissue anomalies, but whether these anatomical pathways contribute independently, and whether they define clinically distinct subtypes, remain unresolved. We integrated genetic ca...

Ultrasound-activated Cu2−XSe/TiO2 heterostructured nanosonosensitizer enables coordinated induction of ferroptosis and cuproptosis for tumor immunotherapy

Triple-negative breast cancer (TNBC) is a highly aggressive subtype characterized by the absence of actionable molecular targets, high metastatic propensity, and limited responsiveness to current immunotherapies. Although immune checkpoint inhibitors show promise, their clinical...

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

ABSTRACT Extracellular pore domains of ion channels are emerging as dynamic regulatory surfaces, but whether they can be rationally targeted to achieve selective channel modulation remains unclear. Here, using an optimized hotspot‐centric design strategy, we developed Depiv2, a s...

Advancing In Vivo Chimeric Antigen Receptor T‐Cell Engineering to Accelerate Clinical Translation

ABSTRACT Chimeric antigen receptor T‐cell (CAR‐T) therapy is a transformative tumor immunotherapy that redirects autologous T cells to eliminate malignant cells. However, its broader clinical translation is constrained by complex and costly ex vivo manufacturing, variable product...

Disrupted copper homeostasis promotes osteopontin-mediated hepatocyte–stellate cell crosstalk in Wilson disease

Wilson disease is a prototypical disorder of copper metabolism in which hepatic copper overload drives progressive liver injury and fibrosis, yet the molecular mechanisms linking copper accumulation to fibrogenesis remain poorly defined. Here, we identify osteopontin (OPN) as a c...

Establishment of stratified reference intervals for serum CA125 using five algorithms based on real-world big data and evaluation of clinical performance

To address the lack of localized validation and precise stratification of reference intervals (RIs), this study used real-world health-checkup big data and five indirect algorithms to establish RIs for serum CA125, evaluated the consistency among the algorithms and their clinical...