First Affiliated Hospital of Xi'an Jiaotong University

F13A1 enhances temozolomide resistance in glioblastoma via activation of the NF-κB signalling pathway

Acquired resistance to temozolomide (TMZ) is a principal driver of therapeutic failure and tumour recurrence in glioblastoma (GBM). This study sought to elucidate the molecular underpinnings of this resistance, aiming to identify viable prognostic markers and therapeutic targets...

Diurnal fluctuation of plasma Alzheimer’s disease biomarkers in healthy young Chinese adults

Plasma amyloid-β (Aβ) and phosphorylated tau (P-tau) are becoming biomarkers for Alzheimer’s disease (AD) diagnosis. However, the variation of plasma levels among different sampling times remains underexplored. In this study, we investigated the diurnal fluctuation of plasma biom...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Analysis of the awareness of core knowledge on lung cancer prevention and treatment among relatives of medical students

Abstract Background Medical students are well-positioned to share scientifically valid and precise information about lung cancer prevention with their families. This practice plays a crucial role in enhancing awareness of core knowledge on lung cancer prevention and treatment (CK...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Development and validation of a multifeature-integrated nomogram for predicting postoperative survival in macrotrabecular-massive hepatocellular carcinoma

Macrotrabecular-Massive Hepatocellular Carcinoma (MTM-HCC) represents a highly aggressive histologic subtype associated with a poor prognosis. This study aimed to construct and validate a Multifeature-Integrated Nomogram model based on clinical, pathological, and imaging characte...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...

P1.076. An Ex Vivo Experimental Study on the Correlation Between Flask-Shaped Gastric Tube Width and Abdominal Gastric Volume

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background After esophagectomy, conventional narrow gastric tubes ensure length but markedly reduce residual gastric volume, potentially impairing postoperative storage and digestion. A flask-shaped design...

P1.078. Long-Term Follow-Up of Tislelizumab Combined With Chemotherapy or Radiotherapy as Neoadjuvant Therapy for Resectable Esophageal Squamous Cell Carcinoma (TINES)

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Esophageal squamous cell carcinoma (ESCC) is a prevalent and aggressive malignancy with limited treatment options. Neoadjuvant therapy has shown promise in improving surgical outcomes and overall sur...

P1.055. Combination of CAR-T Cell Therapy With Immune Checkpoint Inhibition Enhances Anti-Tumor Efficacy in Esophageal Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Chimeric antigen receptor (CAR)-T cell therapy has limited efficacy in solid tumors like esophageal squamous cell carcinoma (ESCC). This study investigates whether combining CAR-T cells with an anti-...

Red nucleus contributes to the maintenance of neuropathic pain in male rats via CCL3-CCR5 axis

The latest evidence indicates that the red nucleus (RN) contributes not only to motor control, but also to sensory processing and emotion regulation. Here, we demonstrate that the RN participates in the maintenance of neuropathic pain via CCL3-CCR5 axis. Following spared nerve in...

IL-6 signaling drives treg dysfunction and pathogenic Th1-like polarization in major depressive disorder

Major depressive disorder (MDD) is pathologically associated with inflammatory-immune dysregulation. While regulatory T cells (Tregs) are essential for immune homeostasis, clinical evidence have reported paradoxical dynamics (deficiency vs. expansion) of peripheral Tregs in MDD p...

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

Cumulative body mass index burden from childhood to mid-adulthood in relation to subclinical cardiovascular outcomes: The potential mediating role of cardiovascular risk factors

The associations of long-term body mass index (BMI) exposure, including both cumulative burden and increasing trends from childhood to adulthood, with subclinical cardiovascular outcomes remain incompletely understood, especially across distinct life stages. This study aimed to e...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Lysosome‐Targeted Self‐Adjuvanting Ammonia Nanogenerator Potentiates Hepatocellular Carcinoma Immunotherapy via Ammonia Death

ABSTRACT Ammonia death is a recently identified form of regulated cell death with unique molecular mechanisms and prominent anticancer activity. Nevertheless, its efficacy is severely restricted by the absence of tumor‐targeted ammonia delivery vehicles and poorly defined immunog...