First Affiliated Hospital of Wenzhou Medical University

XPR1 Promotes the Malignant Phenotypes of Thyroid Carcinoma Cells Partly Through NF-κB-Related Signaling

Background: Xenotropic and polytropic retrovirus receptor 1 (XPR1) is highly expressed in human thyroid carcinoma (TC), yet its functional role remains unclear. In this study, we sought to determine whether XPR1 participates in the progression of thyroid carcinoma and to further...

Associations between patient safety culture, occupational exposure behaviours and patient safety behaviours among operating theatre nurses: a multicentre cross-sectional study

Patient safety in operating theatres is influenced by organisational safety culture and nurses’ safety-related behaviours. Occupational exposure remains a frequent hazard in perioperative settings; however, its relationship with patient safety culture (PSC) and patient safety beh...

Multi-Scale MRI, Radiology Reports, and Blood Biomarker–Guided Multimodal Deep Learning for Predicting Postoperative Recurrence in Cervical Cancer: A Multicenter Study

Objectives: Cervical cancer (CC) remains a leading cause of cancer-related morbidity and mortality among women worldwide, with postoperative recurrence posing a major challenge to long-term survival. Multimodal data integration, including imaging, textual, and clinical informatio...

An electronic health record-derived glycemic variability-enhanced triglyceride-glucose index for early mortality risk stratification in critically ill patients with acute myocardial infarction: a derivation and external validation study

Electronic health records (EHRs) contain repeated glucose measurements routinely collected during critical care, yet these data are rarely incorporated into early risk-stratification tools for acute myocardial infarction (AMI). The conventional triglyceride-glucose (TyG) index re...

Development and validation of a nomogram for predicting disease outcomes in elderly females with lung cancer metastatic to the bone

The incidence of lung cancer in elderly women is gradually increasing and the prognosis is even more worrying. Notably, approximately one-third of these patients develop bone metastases. The main objective of this study is to develop and validate a tool to achieve accurate progno...

Interpretable multimodal fusion of 18F-PSMA-1007 PET/CT and mpMRI for preoperative ISUP grade prediction in primary prostate cancer

Accurate preoperative International Society of Urological Pathology (ISUP) grading of prostate cancer (PCa) is critical for clinical decision-making. While multi-parametric MRI (mpMRI) is routine, it struggles with occult high-risk lesions due to limited metabolic insights. PET/C...

Analysis of Intelligent Privacy Protection Mechanisms for Smart Healthcare in the Context of the Internet of Things

In Internet of Things-based smart healthcare, while medical data sharing and model training are driving industry development, sensitive patient information is easily stolen and misused, and traditional data processing models struggle to balance security and usability. This resear...

Xanthatin directly targets ZDHHC7 to inhibit NLRP3 palmitoylation and inflammasome activation, alleviating sepsis and acute lung injury

Aberrant activation of the NLRP3 inflammasome drives the pathogenesis of diverse inflammatory diseases, including acute respiratory distress syndrome (ARDS) and sepsis. Among the post-translational modifications regulating NLRP3, S-palmitoylation contributes to NLRP3 localization...

Prediction of low oocyte retrieval in young women undergoing IVF/ICSI: a multicenter external validation study

Abstract Objective To externally validate a previously developed pretreatment prediction nomogram for identifying young women at risk of low oocyte retrieval (LOR). Methods This multicenter retrospective study included 14,702 women aged ≤ 35 years undergoing their first in vitro...

Proactive Health Behavior During Pregnancy

Proactive health behavior may enhance maternal well-being during pregnancy, yet the concept remains insufficiently defined in pregnancy-related care and nursing practice. This study used Rodgers’ evolutionary method of concept analysis to clarify the concept and its relevance for...

Efficacy of hemodynamic profiling-guided antihypertensive therapy in elderly patients with early morning hypertension: a randomized controlled multicenter clinical study

Abstract Objective To evaluate the efficacy of hemodynamic profiling (HDpro)-guided antihypertensive therapy in elderly patients with uncontrolled morning hypertension. Methods A multicenter randomized controlled trial was conducted in 9 hospitals in Zhejiang Province, enrolling...

Integrated Assessment of Sarcopenia in Patients with Gastric Cancer Using Deep Learning and Radiomics

ABSTRACT Background Sarcopenia is a common condition in patients with gastric cancer that is associated with poor survival and adverse clinical outcomes. Conventional diagnostic approaches are time‐consuming, limiting large‐scale clinical implementation. This study aimed to devel...

Deep learning CT signature for predicting early liver metastases in pancreatic ductal adenocarcinoma

Accurately predicting the risk of early liver metastases (ELM) and identifying patients who are most likely to benefit from neoadjuvant therapy (NAT) are critical for pancreatic ductal adenocarcinoma (PDAC). Here, we develop a Mamba-based predictive model that integrates imaging...

Heat stress enhances gut microbial arginine catabolism to amplify MyD88-dependent inflammatory responses

As global temperatures continue to rise, heat stress (HS) has emerged as a major health threat of growing concern. HS triggers systemic inflammation and multi-organ damage, but so far its molecular mechanisms remain unclear. In this study, we explored the potential mechanism by w...

Comparison of seven machine learning models for predicting prolonged PACU length of stay: performance evaluation and identification of key influencing factors

Abstract Background Prolonged stays in the post-anesthesia care unit (PACU) significantly increase healthcare resource utilization and delay postoperative recovery. Current research on PACU prolonged stays is mostly limited to univariate analyses, lacking multidimensional, high-a...

Systemic Coagulation-Inflammation Index Predicts Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage: Mediation by Delayed Cerebral Ischemia

The systemic coagulation-inflammation (SCI) index reflects both coagulopathic and inflammatory dynamics. We investigated its association with delayed cerebral ischemia (DCI) and functional outcome in aneurysmal subarachnoid hemorrhage (aSAH), explored the mediation effect of DCI...

USP10 mitigates Ang II–induced atrial remodeling and atrial fibrillation susceptibility by deubiquitinating NDUFS1

Atrial fibrillation (AF) contributes to cardiovascular morbidity and mortality. Ubiquitin-specific peptidase 10 (USP10) plays a crucial role in numerous cellular processes; however, its particular role in AF remains largely unexplored. In the present study, USP10 expression was a...

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

Associations of C-reactive protein-triglyceride-glucose index and cholesterol-high-density lipoprotein-glucose index with heart disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: a cohort study from CHARLS

Abstract Background Although the C-reactive protein-triglyceride-glucose index (CTI) and cholesterol-high-density lipoprotein-glucose index (CHG) have both been implicated in adverse cardiovascular outcomes, their comparative predictive performance for incident heart disease amon...

Prolonged growth hormone pretreatment is associated with improved embryo quality in women with poor quality embryos in previous IVF cycles

Abstract Background Approximately 10–15% of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles have most embryos of poor quality, often characterized by extensive anuclear cytoplasmic fragments. These cycles are usually associated with poor reproducti...