First Affiliated Hospital of Wenzhou Medical University

Determination of Chlorination Disinfection By-products on Healthcare Environmental Surfaces by Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry

Chlorine-based disinfectants are standard for environmental-surface disinfection in healthcare facilities, yet their reaction with organic residues generates disinfection by-products (DBPs) whose occurrence, levels, and occupational relevance on hospital surfaces remain uncharact...

Cardiomyocyte-enriched OTUD5 alleviates pathological myocardial hypertrophy by deubiquitinating STAT3 and modulating the STAT3–PGC-1α axis

Abstract Pathological cardiac hypertrophy presents a important public health challenge, particularly in aging populations, highlighting the urgent need for novel therapeutic targets. This study investigates the role and molecular mechanisms of OTUD5 in pathological cardiac hypert...

ATG16L2 as a prognostic biomarker and therapeutic target in kidney renal clear cell carcinoma

Kidney renal clear cell carcinoma (KIRC) carries substantial clinical challenges. This study examined ATG16L2 , an autophagy-related gene family member, across TCGA, CPTAC, GEO, and an independent cohort to assess its expression patterns, clinicopathological associations, and pro...

Association Between Preoperative Tea Drinking Habits and Postoperative Ileus in Colorectal Cancer Patients: A Propensity Score-Matched Study

Objective This study evaluated whether preoperative tea consumption reduces postoperative ileus risk after colorectal cancer surgery, given tea’s anti-inflammatory and antioxidant properties. Methods In this retrospective cohort of 681 patients, tea drinkers (≥1 cup/day, n = 191)...

Enteric-gated nano–probiotic living nanozyme for gut-directed redox–mitochondrial protection in cisplatin-induced acute kidney injury

Oral nano-biohybrid therapeutics provide opportunities for gut–organ axis intervention, but gastrointestinal transit often compromises both probiotic viability and nanozyme activity. Here, we developed CeO 2 @LP@EL, an enteric-gated nano–probiotic living nanozyme constructed by d...

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O ‐GlcNAcylation‐Induced m6A Demethylation of HRAS

ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is driven by nutrient stress through incompletely defined epigenetic mechanisms. This study demonstrates that lipid stress activates the hexosamine biosynthesis pathway (HBP), elevating O ‐linked β‐N‐acetylglucosami...

Coniferaldehyde Reverses PGK1–3-Phosphoglycerate–L-Serine Metabolic Reprogramming in Hindlimb Ischemia

Background/Objectives: Ischemic skeletal muscle undergoes metabolic remodeling that may influence vascular repair. We investigated whether coniferaldehyde (CA) regulates a phosphoglycerate kinase 1 (PGK1)–3-phosphoglycerate (3PG)–L-serine axis in mouse hindlimb ischemia (HLI). Me...

Mode‐Selective C═C and C─N Vibrational Coupling Modulates Nonradiative Decay in Regioisomeric Organic Phosphorescent Emission

ABSTRACT Structural isomerization has emerged as an effective strategy for improving the performance of organic room‐temperature phosphorescent materials, but reported explanations are mainly attributed to differences in molecular packing, spin‐orbit coupling, excited‐state elect...

A DNA Nanoplatform with Rolling Circle-DNAzyme Feedback Programming for Autonomous Exponential Amplification Enables Multiplexed Orthogonal miRNA Profiling toward Precise Diagnosis of Bladder Cancer

Abstract Simultaneous and sensitive detection of multiple microRNAs in complex biological and clinical serum samples is critical for early and accurate bladder cancer (BC) diagnosis. Here, by integrating I-R3-mediated self-cleavage-coupled feedback amplification into three indepe...

RSPO1–LGR4 axis drives cervical cancer progression via activation of the EGFR/Src/ERK/AKT signaling pathway

Cervical cancer (CCa) is a leading cause of cancer-associated mortality among women globally, posing a substantial health burden, particularly in low- and middle-income countries where HPV vaccination coverage remains limited. Therefore, identifying novel therapeutic targets to i...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Development and Analytical Validation of a Smartphone‐Based Quantitative Lateral Flow Immunoassay for Serum Cystatin‐C

ABSTRACT Background Cystatin‐C is an important renal function biomarker, but conventional quantification requires centralized laboratory analyzers, limiting timely testing in primary care and resource‐limited settings. Methods We developed and validated a quantitative smartphone‐...

Repurposing ritonavir to induce proteasomal degradation of IE1 for inhibition of human cytomegalovirus replication

Human cytomegalovirus (HCMV) is a major pathogen affecting immunocompromised individuals. Current antiviral drugs target the mid-to-late stages of viral replication but are limited by toxicity and drug resistance. The IE1 protein serves as a key early regulator of HCMV replicatio...

Chlorogenic Acid Derivative B11 Inhibits Glioma Proliferation by Targeting MST4 to Regulate Oxidative Stress

ABSTRACT This study focuses on the mechanism of action of chlorogenic acid derivative B11 on glioma. Although chlorogenic acid exhibits certain anti‐tumor activity, it has limitations such as low bioavailability, broad action targets, and insufficient specificity, which restrict...

Dissecting the associations of cardiovascular health, biological aging, and blood DNA methylation signatures with chronic respiratory disease risk

The interplay between cardiovascular health (CVH), biological aging, and underlying epigenetic mechanisms in relation to chronic respiratory diseases (CRDs) remains unclear. We conducted a large-scale prospective cohort study including 181,955 participants from the UK Biobank. Ca...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

ABSTRACT Nitric oxide (NO)‐based cancer therapy is fundamentally limited by poor intratumoral penetration of exogenous donors and their inability to sustain localized relevant flux. Here, a multistimuli‐activated Janus nanomotor was developed to interconnect nonenzymatic and enzy...

Association between life’s essential 8 and epilepsy

Epilepsy, a prevalent chronic neurological disorder, has significant neurobiological, cognitive, psychological, and social implications. The American Heart Association (AHA) introduced Life’s Essential 8 as a key metric for assessing cardiovascular health. This study aims to inve...

Development and validation of a machine learning model integrating clinical and structural brain morphometric features for predicting postherpetic neuralgia: a multicenter cohort study with retrospective development and prospective external validation in China

Postherpetic neuralgia (PHN) is a common and difficult-to-treat complication of herpes zoster (HZ). Early identification of patients at high risk may facilitate risk stratification and individualized intervention. This study aimed to integrate clinical variables with three-dimens...