First Affiliated Hospital of Wenzhou Medical University

Coniferaldehyde Reverses PGK1–3-Phosphoglycerate–L-Serine Metabolic Reprogramming in Hindlimb Ischemia

Background/Objectives: Ischemic skeletal muscle undergoes metabolic remodeling that may influence vascular repair. We investigated whether coniferaldehyde (CA) regulates a phosphoglycerate kinase 1 (PGK1)–3-phosphoglycerate (3PG)–L-serine axis in mouse hindlimb ischemia (HLI). Me...

A DNA Nanoplatform with Rolling Circle-DNAzyme Feedback Programming for Autonomous Exponential Amplification Enables Multiplexed Orthogonal miRNA Profiling toward Precise Diagnosis of Bladder Cancer

Abstract Simultaneous and sensitive detection of multiple microRNAs in complex biological and clinical serum samples is critical for early and accurate bladder cancer (BC) diagnosis. Here, by integrating I-R3-mediated self-cleavage-coupled feedback amplification into three indepe...

Mode‐Selective C═C and C─N Vibrational Coupling Modulates Nonradiative Decay in Regioisomeric Organic Phosphorescent Emission

ABSTRACT Structural isomerization has emerged as an effective strategy for improving the performance of organic room‐temperature phosphorescent materials, but reported explanations are mainly attributed to differences in molecular packing, spin‐orbit coupling, excited‐state elect...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

RSPO1–LGR4 axis drives cervical cancer progression via activation of the EGFR/Src/ERK/AKT signaling pathway

Cervical cancer (CCa) is a leading cause of cancer-associated mortality among women globally, posing a substantial health burden, particularly in low- and middle-income countries where HPV vaccination coverage remains limited. Therefore, identifying novel therapeutic targets to i...

Development and Analytical Validation of a Smartphone‐Based Quantitative Lateral Flow Immunoassay for Serum Cystatin‐C

ABSTRACT Background Cystatin‐C is an important renal function biomarker, but conventional quantification requires centralized laboratory analyzers, limiting timely testing in primary care and resource‐limited settings. Methods We developed and validated a quantitative smartphone‐...

Repurposing ritonavir to induce proteasomal degradation of IE1 for inhibition of human cytomegalovirus replication

Human cytomegalovirus (HCMV) is a major pathogen affecting immunocompromised individuals. Current antiviral drugs target the mid-to-late stages of viral replication but are limited by toxicity and drug resistance. The IE1 protein serves as a key early regulator of HCMV replicatio...

Chlorogenic Acid Derivative B11 Inhibits Glioma Proliferation by Targeting MST4 to Regulate Oxidative Stress

ABSTRACT This study focuses on the mechanism of action of chlorogenic acid derivative B11 on glioma. Although chlorogenic acid exhibits certain anti‐tumor activity, it has limitations such as low bioavailability, broad action targets, and insufficient specificity, which restrict...

Dissecting the associations of cardiovascular health, biological aging, and blood DNA methylation signatures with chronic respiratory disease risk

The interplay between cardiovascular health (CVH), biological aging, and underlying epigenetic mechanisms in relation to chronic respiratory diseases (CRDs) remains unclear. We conducted a large-scale prospective cohort study including 181,955 participants from the UK Biobank. Ca...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

Pola-R-CHP in previously untreated DLBCL with international prognostic index score 0–1: a multicenter real-world retrospective study in China

Abstract Purpose Approximately 30% of newly diagnosed diffuse large B-cell lymphoma (DLBCL) cases are categorized as low-risk by the international prognostic index (IPI). Polatuzumab vedotin, rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) has demonstrated e...

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

ABSTRACT Nitric oxide (NO)‐based cancer therapy is fundamentally limited by poor intratumoral penetration of exogenous donors and their inability to sustain localized relevant flux. Here, a multistimuli‐activated Janus nanomotor was developed to interconnect nonenzymatic and enzy...

Association between life’s essential 8 and epilepsy

Epilepsy, a prevalent chronic neurological disorder, has significant neurobiological, cognitive, psychological, and social implications. The American Heart Association (AHA) introduced Life’s Essential 8 as a key metric for assessing cardiovascular health. This study aims to inve...

Development and validation of a machine learning model integrating clinical and structural brain morphometric features for predicting postherpetic neuralgia: a multicenter cohort study with retrospective development and prospective external validation in China

Postherpetic neuralgia (PHN) is a common and difficult-to-treat complication of herpes zoster (HZ). Early identification of patients at high risk may facilitate risk stratification and individualized intervention. This study aimed to integrate clinical variables with three-dimens...

XPR1 Promotes the Malignant Phenotypes of Thyroid Carcinoma Cells Partly Through NF-κB-Related Signaling

Background: Xenotropic and polytropic retrovirus receptor 1 (XPR1) is highly expressed in human thyroid carcinoma (TC), yet its functional role remains unclear. In this study, we sought to determine whether XPR1 participates in the progression of thyroid carcinoma and to further...

Associations between patient safety culture, occupational exposure behaviours and patient safety behaviours among operating theatre nurses: a multicentre cross-sectional study

Patient safety in operating theatres is influenced by organisational safety culture and nurses’ safety-related behaviours. Occupational exposure remains a frequent hazard in perioperative settings; however, its relationship with patient safety culture (PSC) and patient safety beh...

An electronic health record-derived glycemic variability-enhanced triglyceride-glucose index for early mortality risk stratification in critically ill patients with acute myocardial infarction: a derivation and external validation study

Electronic health records (EHRs) contain repeated glucose measurements routinely collected during critical care, yet these data are rarely incorporated into early risk-stratification tools for acute myocardial infarction (AMI). The conventional triglyceride-glucose (TyG) index re...

Multi-Scale MRI, Radiology Reports, and Blood Biomarker–Guided Multimodal Deep Learning for Predicting Postoperative Recurrence in Cervical Cancer: A Multicenter Study

Objectives: Cervical cancer (CC) remains a leading cause of cancer-related morbidity and mortality among women worldwide, with postoperative recurrence posing a major challenge to long-term survival. Multimodal data integration, including imaging, textual, and clinical informatio...

Development and validation of a nomogram for predicting disease outcomes in elderly females with lung cancer metastatic to the bone

The incidence of lung cancer in elderly women is gradually increasing and the prognosis is even more worrying. Notably, approximately one-third of these patients develop bone metastases. The main objective of this study is to develop and validate a tool to achieve accurate progno...

Interpretable multimodal fusion of 18F-PSMA-1007 PET/CT and mpMRI for preoperative ISUP grade prediction in primary prostate cancer

Accurate preoperative International Society of Urological Pathology (ISUP) grading of prostate cancer (PCa) is critical for clinical decision-making. While multi-parametric MRI (mpMRI) is routine, it struggles with occult high-risk lesions due to limited metabolic insights. PET/C...