First Affiliated Hospital of Wenzhou Medical University

The global cardiovascular-kidney-liver-metabolic burden from 1990 to 2023

Background The cardiovascular-kidney-liver-metabolic (CKLM) framework represents the multi-organ interplay of systemic metabolic disorders that drive the global burden of cardiovascular diseases (CVD). Methods This study is a descriptive epidemiological analysis of the Global Bur...

Associations of C-reactive protein-triglyceride-glucose index and cholesterol-high-density lipoprotein-glucose index with heart disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: a cohort study from CHARLS

Abstract Background Although the C-reactive protein-triglyceride-glucose index (CTI) and cholesterol-high-density lipoprotein-glucose index (CHG) have both been implicated in adverse cardiovascular outcomes, their comparative predictive performance for incident heart disease amon...

Prolonged growth hormone pretreatment is associated with improved embryo quality in women with poor quality embryos in previous IVF cycles

Abstract Background Approximately 10–15% of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles have most embryos of poor quality, often characterized by extensive anuclear cytoplasmic fragments. These cycles are usually associated with poor reproducti...

Longitudinal Associations Among Maternal Health Literacy, Psychological Empowerment and Health‐Promoting Behaviours in Rural Pregnant Women: A Cross‐Lagged Panel Study

AIMS: To examine longitudinal associations among maternal health literacy, psychological empowerment and health-promoting behaviours across pregnancy among rural pregnant women. DESIGN: Prospective cohort study. METHODS: Between 1 May 2023 and 15 January 2024, 694 rural pregnant...

A unified mechano-ionic skin for resolving native electromechanical coupling

The beat-to-beat electromechanical coupling between cardiac excitation and arterial pulse propagation encodes vital cardiovascular insights, but resolving this coherence in wearables is hindered by the spatial decoupling of sensors and attenuated epidermal signals. Here, we repor...

Ultrasmall PolymericMicelles Enable Noninvasive TransdermalRosiglitazone Delivery via Lipid Fluidization and Transcytosis

Abstract Noninvasive transdermal drug delivery (TDD) offers sustained therapeutic release but is hindered by the stratum corneum (SC) barrier. Herein, we report ultrasmall polymeric micelles (PMs) embedded in poly(vinyl alcohol) hydrogels for the passive TDD of rosiglitazone (RGT...

Macrophage RIPK3 facilitates TRAF6 K63-linked ubiquitination and exacerbates acute pancreatitis

Abstract Acute pancreatitis (AP) is characterized by acinar cell injury and death triggered by multiple etiologies, culminating in local and systemic inflammatory responses. Current therapeutic options for AP, particularly severe AP, remain limited. While RIPK3-mediated necroptos...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

Oral anticoagulation therapy in nonagenarian patients with atrial fibrillation: usage patterns, predictors, and in-hospital outcomes from a single-center retrospective study

Abstract Background Atrial fibrillation (AF) is highly prevalent in nonagenarians (≥ 90 years). However, this group is often excluded from clinical trials, leaving limited real-world evidence on oral anticoagulant (OAC) use, safety, and efficacy. This study sought to investigate...

A Metabo‐Reprogramming Niche Remodeling System Halts Osteoarthritis by Restoring the FGF21‐Arginine Axis

Osteoarthritis (OA), a global leading cause of chronic pain and disability, lacks disease-modifying osteoarthritis drugs (DMOADs) targeting its core pathogenesis. scRNA-seq of human OA cartilage showed marked depletion of a high-arginine-metabolism chondrocyte subpopulation drivi...

Stromal Cells Recruitment by Sono‐Piezoelectric/Pyroelectric Peptide Hydrogels Promotes Bone Regeneration After Postsurgical Osteosarcoma Recession: A Real‐World‐Matched Study

ABSTRACT Currently, the elimination of postsurgical osteosarcoma (OS) and defect repair are still separately explored, which is unlike real‐world clinical scenarios. Inadequate bone marrow stromal cells (BMSCs) compromise their repair and antitumor efficiencies. Here, PFSSTKT (PF...

Derivation of a novel risk assessment model of venous thromboembolism in hospitalized patients

Background Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), significantly contributes to morbidity and mortality among hospitalized patients. Despite the existence of various VTE risk assessment models (RAMs), their performance...

Predictors of falls efficacy among community-dwelling older adults with ischemic stroke in Wenzhou, China: a cross-sectional study

Purpose This study aimed to examine the level of falls efficacy and identify its predictors among community-dwelling older adults with ischemic stroke in Wenzhou, China. Design/methodology/approach A cross-sectional descriptive study was conducted with 335 participants aged 60–75...

Dose-response relationship of prophylactic norepinephrine infusion for prevention of spinal anesthesia-induced hypotension during caesarean delivery: A comparative study of normal weight and obese parturients.

Obese parturients are at increased risk of spinal anesthesia-induced hypotension during cesarean delivery, but optimal prophylactic norepinephrine dosing remains unclear. In this randomized, double-blind, dose-response study, 200 parturients undergoing elective cesarean delivery...