First Affiliated Hospital of Nanchang University

Prevalence and characteristics of colonic diverticulosis: a retrospective cross-sectional study in Southern China

Abstract Background Recent literature indicated that the prevalence of colonic diverticulosis in China is increasing. However, there is limited information on colonic diverticulosis in China. Our study aims to determine the prevalence and characteristics of colonic diverticulosis...

Beyond the Meta‐Analysis: Reconsidering Class Effects, Resistance Surveillance, and Dosing Optimization in Tegoprazan–Amoxicillin Dual Therapy

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

PSMD14 reduced microglial M2 polarization to promote ferroptosis and aggravate traumatic brain injury through the induction of BMP6/SMAD3 pathway

The present study aimed to investigate the functional role of proteasome 26S subunit non-ATPase 14 (PSMD14) in traumatic brain injury (TBI) and further elucidate its molecular mechanisms linking ferroptosis to microglial M2 polarization. A total of 52 clinical samples from TBI pa...

Development and internal validation of an explainable machine learning model for predicting functional disability trajectories in hospitalized older patients with chronic low back pain

Functional disability poses a critical challenge to healthy aging in older patients with chronic low back pain (CLBP). However, understanding of heterogeneous functional disability trajectories in this population remains limited, and effective risk stratification tools are lackin...

A Cross-Sectional Study of Short-Video Viewing and Young Adult Health: Dose–Response Relationships with Sleep, Dream Anxiety, Ocular Surface, and Quality of Life

Background: Short-video platforms (e.g., Douyin, TikTok) have gained immense popularity among young adults, yet their addictive potential and health consequences remain understudied. Unlike gaming addiction, which has been linked to myopia and mental distress, short-video viewing...

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

ABSTRACT Butyrate (BA) is essential for intestinal health, but its intestinal therapeutic applications are hindered by its malodorous nature, premature gastric absorption, and rapid intestinal metabolism. To address these challenges, an inodorous macromolecule β‐glucan‐BA (GLU‐BA...

Vaccinia-related kinase 2 confers pancreatic cancer with gemcitabine resistance through TPI1-driven aerobic glycolysis

Abstract Gemcitabine(GEM)-based chemotherapy is considered the first-line regimen for pancreatic cancer(PC), but the poor responsiveness and chemoresistance greatly limit its application. Metabolic reprogramming, especially aerobic glycolysis, which is regulated by glycolytic enz...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

HE-referenced eosinophil assessment and cutoff estimation using Congo red and Chromotrope 2R staining in chronic rhinosinusitis with nasal polyps

Abstract This cross-sectional histopathological study aimed to compare eosinophil visualization and quantification using Congo red, Chromotrope 2R, and conventional hematoxylin–eosin (HE) staining in chronic rhinosinusitis with nasal polyps (CRSwNP), and to explore HE-referenced...

Identification of pyroptosis-related hub genes and construction of a diagnostic model for acute liver failure based on integrated bioinformatics and machine learning

Acute liver failure (ALF) is a life-threatening syndrome marked by massive hepatocyte loss and dysregulated inflammation. Although pyroptosis, an inflammatory mode of programmed cell death, is thought to contribute to ALF pathogenesis, its exact role has yet to be fully defined....