First Affiliated Hospital of Nanchang University

Novel therapeutics for platinum-resistant ovarian cancer: from biological mechanisms to emerging biomarker-guided strategies

For decades, platinum resistance has remained one of the major barriers to improving outcomes in ovarian cancer. Patients with platinum-resistant ovarian cancer (PROC) generally have shorter overall survival and lower response rates to second-line treatment than those with platin...

Probiotics modulate the interactions between gastric and intestinal microbiota after Helicobacter pylori eradication

Standard eradication therapy for Helicobacter pylori ( H. pylori ) induces substantial gastrointestinal dysbiosis. Here, we investigated whether probiotic supplementation mitigates these spatial microbial perturbations and facilitates ecological recovery post-eradication. C57BL/6...

Protein Glutamylation: From Cytoskeleton to Signaling

ABSTRACT Protein glutamylation is a reversible post‐translational modification (PTM) that involves the enzymatic addition of glutamate moieties to, and their removal from, target proteins, thereby modulating their activity, stability, localization, and molecular interactions. Ini...

Constitutional mismatch repair deficiency presenting with six primary malignancies over nearly 8 years: a case report

Constitutional mismatch repair deficiency (CMMRD) is a rare cancer predisposition syndrome typically manifesting in early childhood. We report an atypical, adult-onset case of CMMRD in a 26-year-old female harboring a homozygous PMS2 germline nonsense mutation (NM_000535.7:c.1738...

Ursolic acid ameliorates metabolic dysfunction-associated fatty liver disease by regulating the NOX4/ROS/NLRP3 pathway

Ursolic acid (UA) is a monomeric traditional Chinese medicine with unique anti-inflammatory properties. Metabolic fatty liver (MAFL)/metabolic steatohepatitis (MASH) is an early/progressive stage of metabolic dysfunction-associated fatty liver disease (MAFLD). Whether UA affects...

Emerging frontiers in targeted and immunotherapeutic strategies for marginal zone lymphoma

Marginal zone lymphoma (MZL) comprises a heterogeneous group of indolent B-cell non-Hodgkin lymphomas. Most patients have favorable outcomes, but approximately 20% develop early relapse or progression within 24 months. Advances in molecular profiling have identified recurrent alt...

Identification and Experimental Validation of PANoptosis Key Genes for Constructing a PANoptosis Risk Diagnostic Model in Intervertebral Disc Degeneration

BACKGROUND: Intervertebral disc degeneration (IDD) represents a significant health concern globally. This study aimed to identify the PANoptosis key genes (PKGs) associated with IDD and construct a risk diagnosis model METHODS: Single-cell sequencing, machine learning algorithms,...

Distinct neuronal subpopulations in the anterior pretectal nucleus contribute to nitroglycerin-induced cephalic and extracephalic mechanical hypersensitivity

Abstract Background Chronic migraine is characterized by recurrent headache and persistent pain hypersensitivity, often accompanied by sensory symptoms such as photophobia. Although central sensitization within thalamic and brainstem circuits is thought to contribute to migraine...

Rimegepant for vestibular and cochlear symptoms associated with vertigo in a real-world retrospective study

Vertigo commonly co-occurs with cochlear symptoms, yet evidence for calcitonin gene-related peptide (CGRP) receptor antagonists across audiovestibular disorders remains limited. We retrospectively evaluated 54 adults with vertigo who received rimegepant 75 mg daily or every other...

Construction of an m5Cscore based on m5C modification patterns to predict prognosis and personalized treatment outcomes in breast cancer

Accumulating evidence links 5-methylcytosine (m 5 C) modifications to tumor progression and gene regulation. This study aimed to systematically characterize m 5 C modification patterns in breast cancer, elucidate their associations with prognosis and tumor heterogeneity, and prov...

Endocrine adverse events related to immune checkpoint inhibitors in gastric cancer

This study aimed to systematically assess the endocrine adverse reactions associated with Immune checkpoint inhibitors (ICIs) in the treatment of gastric cancer. Data from the FDA Adverse Event Reporting System (FAERS) spanning from Q1 2013 to Q3 2024 were analyzed. The associati...

Machine Learning-Guided Discovery of Natural BACE1 Inhibitors with Enzymatic and Cellular Validation

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by excessive accumulation of β-amyloid (Aβ) peptides in the brain. Beta-secretase 1 (BACE1), the rate-limiting enzyme in the amyloidogenic processing pathway of amyloid precursor protein (A...

A study protocol of multicenter randomized controlled trial comparing three cannulated screws and dynamic condylar screw with medial anatomical buttress plate in treating old femoral neck fracture

Currently, there is no standardized consensus regarding hip preservation strategies for managing old femoral neck fractures. Our previously developed technique, utilizing a dynamic condylar screw (DCS), medial anatomical buttress plate (MABP), and iliac bone grafting (IBG), has b...

Deubiquitinase USP48 Promotes Gastric Cancer Peritoneal Metastasis by Stabilizing S100A9 to Drive Neutrophil Extracellular Traps Formation

ABSTRACT Peritoneal metastasis (PM) represents the primary cause of death in patients with advanced gastric cancer (GC), yet its underlying mechanisms remain poorly understood. Neutrophil extracellular traps (NETs) have emerged as key mediators of tumor progression, but how cance...

An interpretable fecal microbiota-based GBM-SHAP machine-learning model for distinguishing ankylosing spondylitis from healthy controls

Previous studies have identified associations between ankylosing spondylitis (AS) and the gut microbiota. This retrospective secondary analysis aimed to develop and interpret a fecal microbiota-based machine-learning model for distinguishing AS samples from healthy-control sample...

Endoscopic Retrograde Appendicitis Therapy Versus Laparoscopic Appendectomy for Acute Appendicitis: A 10-Year Single-Center Retrospective Cohort Study

INTRODUCTION: Endoscopic retrograde appendicitis therapy (ERAT) is a minimally invasive, organ-preserving treatment for acute appendicitis (AA), but comparative evidence with laparoscopic appendectomy (LA) remains limited.​. METHODS: We retrospectively analyzed 450 patients with...

An interpretable deep learning model based on enhanced CT predicts the recurrence of non-muscle-invasive bladder cancer within 2 years

Accurate risk stratification for non-muscle-invasive bladder cancer (NMIBC) recurrence is essential for personalized treatment. This study aimed to develop and validate a contrast-enhanced computed tomography (CT)-based model for predicting postoperative NMIBC recurrence within t...

Multi‐Omics Genome‐Wide to Explore the Formation and Development Targets for Intracranial Aneurysms

Intracranial aneurysms (IAs) represent a significant and potentially life-threatening category of disease, and there is currently a lack of effective treatment options aimed at preventing the progression of the disease. Accordingly, this study is dedicated to exploring and identi...

Intergenerational support and risk of incident visual impairment among middle-aged and older Chinese adults: a national longitudinal cohort study

Abstract Background Visual impairment is a major contributor to functional decline and reduced quality of life among older adults. While biological and demographic factors are well established, the role of family-based social support remains unclear. In China, intergenerational s...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...