First Affiliated Hospital of Jinan University

Neutrophil to Lymphocyte Ratio and Neurological Outcome in Ischemic Stroke at 4.5 to 24 Hours: A Post Hoc Analysis of TRACE-III Trial

Whether neutrophil to lymphocyte ratio (NLR), as a marker of increased inflammatory response, modifies the efficacy and safety of tenecteplase is uncertain in patients 4.5–24 h after stroke onset. We investigated this in the Tenecteplase Reperfusion Therapy in Acute Ischemic Cere...

Targeting MDA5 induces immunogenic cell death and promotes anti-tumor immunity

Identifying targets to enhance tumor immunity is an urgent need. Although nucleic acid sensors play critical roles in promoting tumor immune clearance, their exceptionally low mutation rate in cancers suggests potential unexplored roles in tumor progression. Here, we demonstrate...

Comparison and clinical validation of different centiloid processing methods in amyloid beta PET

The Centiloid (CL) scale has become a crucial quantitative metric for β-amyloid (Aβ) PET in Alzheimer's disease. However, variability in processing methods complicates its clinical adoption. This study systematically evaluated the reliability and clinical utility of different CL...

Development and application of a smartphone-based thermal contrast amplification reader for photothermal lateral flow immunoassays

The high cost and poor portability of external infrared thermal imagers have limited the widespread adoption of photothermal lateral flow immunoassays (PT-LFIAs) in on-site testing. To address this, we developed a smartphone-based handheld Thermal Contrast Amplification (TCA) Rea...

PCSK9 inhibitors usage in South China: A Multi-Center Real-World Study

Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are effective for lipid management in high-risk patients with atherosclerotic cardiovascular disease. Their inclusion in China’s National Reimbursement Drug List and the Hong Kong Hospital Authority Drug Formulary...

Single-cell and bulk transcriptomic integration identifies a high-CNV, dark-zone-enriched malignant cell state associated with adverse prognosis in GCB-DLBCL

Background Germinal centre B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL) generally has a better prognosis than activated B-cell-like DLBCL, yet a clinically significant subset of patients still develops aggressive disease, suggesting marked malignant cellular heterogeneit...

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72 hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

ABSTRACT Atherosclerotic cardiovascular disease (ASCVD) remains the leading global cause of mortality, with substantial residual inflammatory risk persisting despite statin therapy. We identify a c‐Rel‐driven CD72 hi macrophage subset markedly enriched in human and murine atheros...

High tibial osteotomy for proximal tibial osteonecrosis with medial tibial plateau fracture in a patient with prior knee arthroscopy: a case report

High tibial osteotomy (HTO) is a well-established joint-preserving procedure for unloading the medial compartment of the knee. It has been applied in selected cases of spontaneous osteonecrosis or subchondral insufficiency fracture of the knee. However, the coexistence of proxima...

Large language models for pneumonia detection in radiology reports via text analysis

Pneumonia is a common infection in critically ill patients with poor outcomes, and its identification relies heavily on radiological evidence. Most MIMIC-based pneumonia studies rely on structured codes rather than radiological text, which may limit the precision of pneumonia-rel...

ALKBH5-Dependent m 6 A Demethylation Promotes Cardiac Aging Through SLC38A3 Reduction and Glutamine Metabolic Alteration

BACKGROUND: N 6 -methyladenosine (m 6 A) modification has been linked to various types of physiological and pathological bioprocesses. However, the exact role of m 6 A mRNA methylation in cardiac aging is largely unknown. Here, we show that ALKBH5 (alpha-ketoglutarate-dependent d...

Parenting styles and fertility intention: Mediating effects of childbearing beliefs and psychological resilience

China's declining fertility rate is partly due to low fertility intention among childbearing population. To understand family influence on young people's fertility intention and its underlying mechanisms, this study examines how parenting styles (authoritarian vs. permissive) aff...

Nuciferine Ameliorates Ovariectomy-Induced Bone Loss via TFEB-Mediated Autophagy-Lysosomal Pathway

Background: Postmenopausal osteoporosis is a common metabolic bone disease that leads to reduced bone formation and increased fracture risk. Nuciferine, an aporphine alkaloid from the lotus leaf, can regulate the TFEB-mediated autophagy-lysosomal pathway. This pathway is critical...

Nitric oxide–regulated temporally staged milk exosome hydrogel for the treatment of skin photoaging

Ultraviolet (UV)–induced skin photodamage can lead to sunburn, photoaging, and, in severe cases, precancerous lesions or malignant skin tumors. Cutaneous responses to UV injury exhibit pronounced circadian rhythmicity; however, current strategies focusing solely on physical UV sh...

The abscopal effect and systemic immune reprogramming: from phenomenon to therapeutic design

The classical abscopal effect is defined here as objective regression of a verified non-irradiated tumor lesion following local radiotherapy. An immune abscopal phenomenon denotes a prespecified, reproducible immune change within such a lesion that is attributable to the local in...

Association Between Lithium Use and Suicide‐Related Behaviors in Bipolar Disorder: A Multicenter Study

BACKGROUND: Lithium has long been associated with reduced suicide risk in bipolar disorder; however, evidence from real-world clinical populations remains susceptible to confounding, and the behavioral correlates related to this association are not well characterized. METHODS: In...

Subgroup analysis of tirofiban's effect on early neurological deterioration in AIS-LVO patients undergoing endovascular treatment

Abstract Purpose This study aimed to investigate whether stroke subtype influences the association between tirofiban use and END risk in AIS-LVO patients undergoing endovascular treatment (EVT) . Methods This was a retrospective cohort study of 813 consecutive AIS-LVO patients tr...

Seminiferous Tubules‐Targeted Resveratrol Carbon Dots With Sertoli Cell Biomimetic Vesicles Fusion for Improving Spermatogenesis of Cryptorchidism

ABSTRACT Impaired blood‐testis barrier (BTB) integrity, induced by oxidative stress, is one of the primary factors leading to spermatogenic disorders in cryptorchidism. Therefore, the targeted elimination of testicular oxidative stress and repair of the BTB are promising strategi...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

Severe adhesive probability score (SAPS): an imaging scoring system for predicting adherent perinephric fat in patients with infectious nonfunctional kidney

To identify and validate clinical and radiological predictors of perirenal fat adherence and develop a prediction model for perirenal fat adhesions in infectious nonfunctioning kidneys. A retrospective study was conducted on 277 patients who underwent robotic-assisted or laparosc...

Label-free dynamic cell imaging of fresh ex vivo spinal meningiomas: a nine-case optical-pathological correlation study with specimen-level H&E references

Spinal meningioma subtype and grade still rest on haematoxylin and eosin (H&E) morphology, but permanent sections become available only after fixation and embedding, and intraoperative assessment of fresh tissue relies mainly on frozen section. Dynamic cell imaging (DCI), a label...