First Affiliated Hospital of Guangzhou Medical University

Causal association between plasma vascular endothelial growth factor family proteins and placenta previa

This study investigates associations between genetically proxied plasma vascular endothelial growth factor (VEGF) family proteins and placenta previa using 2-sample Mendelian randomization (MR). Exposure GWAS summary statistics were obtained from the UK Biobank and IEU resources,...

Nebulized lidocaine for preventing postoperative pulmonary complications in major abdominal surgery

Despite the lung-protective ventilation strategy, high incidence of postoperative pulmonary complications (PPCs) after major non-cardiac surgery remains a major concern in the perioperative care due to high morbidity and mortality. The study aimed to evaluate the efficacy and saf...

Comparison and clinical validation of different centiloid processing methods in amyloid beta PET

The Centiloid (CL) scale has become a crucial quantitative metric for β-amyloid (Aβ) PET in Alzheimer's disease. However, variability in processing methods complicates its clinical adoption. This study systematically evaluated the reliability and clinical utility of different CL...

Extracellular matrix–targeted TNC-scFv armoring enhances CAR T cell persistence and antitumor activity in solid tumors

Chimeric antigen receptor T cell (CAR T cell) therapy has shown limited efficacy in solid tumors, largely due to physical and immunosuppressive barriers imposed by the tumor microenvironment (TME). Tenascin-C (TNC), an extracellular matrix protein highly expressed in multiple sol...

Sulfur dioxide exposure is associated with kidney dysfunction and creatinine abnormalities in Chinese patients with cardiovascular disease or hypertension

This observational study examined the association between long-term ambient air pollution exposure and renal dysfunction among middle-aged and elderly Chinese individuals with hypertension or heart disease. Although previous studies have mainly focused on particulate matter and n...

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

ABSTRACT Coronaviruses have persistently triggered global pandemics in the 21 st century, featuring either high transmissibility or high pathogenicity. A hallmark of these infections is the delayed activation of innate immune responses, resulting in dysregulated antiviral signali...

Association between Airway Mucus Plugs on Computed Tomography and Respiratory Outcomes in Participants with COPD and with Preserved Spirometry: Findings from a Chinese Population

Abstract Rationale Airway mucus plugs are a prognostic marker in moderate-to-very severe chronic obstructive pulmonary disease (COPD), but their association with respiratory outcomes has been insufficiently evaluated among participants with preserved spirometry and asymptomatic C...

Phase 1 Dose-Escalation Study of the Rapid-Clearance Radioligand [ 177 Lu]Lu-P17-087 in Metastatic Castration-Resistant Prostate Cancer: Dosimetry, Safety, and Preliminary Efficacy

Given the rapid systemic clearance and favorable kinetic profile of the novel DOTA(GA)2-conjugated ligand [177Lu]Lu-P17-087, this phase 1 study aimed to systematically evaluate the safety, pharmacokinetics, dosimetry, and preliminary antitumor activity of escalating therapeutic a...

Causal inference maps the sex-dimorphic genetic architecture and inflammatory-metabolic networks underpinning perceived aging in UK Biobank

Self-perceived facial aging is an externally observable aging-related phenotype that may reflect both biological and psychosocial dimensions of aging. However, its genetic and molecular determinants, sex-specific heterogeneity, and relationship with systemic aging-related pathway...

Tolerogenic dendritic cells modulate macrophage inflammatory response in Ulcerative colitis: role of IL-1RN

Abstract Background Ulcerative colitis (UC) is a chronic, idiopathic inflammatory disease whose pathogenesis involves various immune cells. Measures that suppress the inflammatory responses of intestinal macrophages are considered crucial for improving ulcerative colitis. In rece...

A biomimetic multienzyme‑mimetic Prussian blue nanozyme for catalytic ROS neutralization and macrophage reprogramming in photoacoustic imaging‑guided immunotherapy of acute lung injury

Acute lung injury (ALI) is a life‑threatening respiratory disease that lacks precise diagnostic tools and specific therapeutic interventions, highlighting an urgent need for theranostic strategies. Here, we developed a biomimetic multienzyme‑mimetic Prussian blue nanozyme (MM@HMP...

Non-apnea electrical impedance tomography for bedside ventilation–perfusion assessment during spontaneous breathing: a prospective cross-over validation study

Conventional saline-contrast electrical impedance tomography (EIT) perfusion imaging typically requires a brief end-expiratory apnea during saline injection to reduce respiratory interference. However, this maneuver is often difficult or impractical in spontaneously breathing pat...

Ratio-preserved, spirometry-defined small airway dysfunction is associated with COPD: evidence from CT quantification and pathological assessments

This study investigated the radiologic and pathologic features of spirometry-defined small airway dysfunction (SAD) in patients with a preserved forced expiratory volume in one second to forced vital capacity ratio (FEV 1 /FVC > 0.7), providing evidence that SAD may be associated...

Interleukin-15-armed trivalent mRNA vaccine elicits robust and durable protection against lethal mpox and vaccinia virus challenges in mice

The global re-emergence of mpox virus (MPXV) poses a critical threat, particularly to vulnerable immunocompromised populations, thus highlighting an urgent need for effective and safe interventions. In this study, we developed and compared three mRNA-LNP candidates: a trivalent c...

Modulation of CD73 by Betulinic acid antagonizes nucleotide metabolic dysregulation in silica nanoparticle-induced pulmonary fibrosis

Silica nanoparticles (SiNPs) exposure presents a growing public-health concern. The mechanisms driving SiNPs-induced pulmonary fibrosis and effective interventions remain unclear. This study investigated the contribution of CD73 to SiNPs-induced pulmonary fibrosis and evaluated t...

The dual role of fibrinogen in vascular permeability and alveolar senescence reveals its potential as a pharmacological target for asthma

Fibrinogen (Fg), a critical mediator in vascular and inflammatory diseases, is poorly understood in asthma pathogenesis. Here, our data support a model in which Fg acts as a dual-function driver of asthma progression through distinct endothelial and epithelial mechanisms, and we...

Effect of Intracameral Air Injection on Corneal Endothelial Cell Loss After Phacoemulsification for Cataracts of LOCS III Nuclear Grade 4 or Higher: A Randomised Clinical Trial

BACKGROUND: To evaluate the effect of intracameral air injection on corneal endothelial cells in patients undergoing phacoemulsification for cataracts with LOCS III nuclear grade 4 or higher. METHODS: A prospective randomised clinical trial. Patients with cataracts of LOCS III nu...

PTK6 inhibition by tilfrinib hinders the proliferation and migration of ovarian cancer cells

Protein Tyrosine Kinase 6 (PTK6) has been implicated in the progression of multiple malignancies; however, its oncogenic role and therapeutic potential in ovarian cancer (OC) remain incompletely defined. This study systematically investigates the biological function and therapeut...

Disordered eating attitudes in hospitalized schizophrenia patients of Guangdong, China: prevalence, associated factors, and the exploratory mediating role of insight in the depression-eating attitude link

This study aimed to examine disordered eating attitudes and their associated factors among hospitalized patients with schizophrenia. The primary objective was to identify sociodemographic, clinical, and psychological factors associated with eating attitudes. The secondary objecti...

A Biomimetic cascade nanoreactor enabled by tumor microenvironment remodeling for precise CO release and enhanced cu-mediated chemodynamic therapy

Prostate cancer (PCa) is the most prevalent malignant tumor in the male genitourinary system. Carbon monoxide (CO) gas therapy and chemodynamic therapy (CDT) have emerged as alternative treatments for cancer. However, the therapeutic efficacy of both approaches is constrained by...