First Affiliated Hospital of Guangzhou Medical University

Tozorakimab to Prevent COPD Exacerbations

BACKGROUND: Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled maintenance therapy. Dysregulated interleukin-33 signaling is implicated in the pathogenesis of COPD. Tozorakimab is a monoclonal antibody tha...

Mutations in EnvZ, KPC, and OmpK36 contribute to the evolution from ceftazidime-avibactam heteroresistance to stable resistance in carbapenem-resistant Klebsiella pneumoniae

Antibiotic heteroresistance, an unstable phenotype wherein a minority-resistant subpopulation coexists with a majority-susceptible population, can evolve to stable resistance following in vivo antibiotic exposure, thereby substantially increasing the risk of treatment failure. Ho...

CD9 + B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

ABSTRACT Adenoid hypertrophy (AH) is associated with excessive proliferation of germinal center B (GC‐B) cells, yet the mechanisms underlying GC regression and termination remain poorly understood. This study used single‐cell RNA sequencing (scRNA‐seq) to profile the cellular com...

IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis

ABSTRACT Induction of pyroptosis is a novel strategy for multiple myeloma (MM) treatment, but the underlying mechanism remains elusive. In the analysis of the transcriptomic profile in pyroptotic MM cells, we find the interferon‐alpha inducible protein IFI27 is strikingly upregul...

Results reporting and primary endpoint achievement in interventional therapeutic trials for pleural mesothelioma, 2005–2025: a cross-sectional analysis

Pleural mesothelioma (PM) is a rare and aggressive malignancy in which therapeutic progress depends on a limited clinical trial evidence base. Although trial registration has improved transparency, the extent to which registered trials generate publicly available and clinically i...

Plasma metabolomic signatures enable the diagnosis and prognosis of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a progressive heterogeneous lung disease driving global illness and death, yet reliable biomarkers for its early diagnosis, molecular subtyping and prognosis are lacking. Here, we conduct targeted plasma metabolomic profiling in two...

P1.059. Calcium-Channel Blocker Use and Survival After Neoadjuvant Therapy for Locally Advanced ESCC

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Calcium-channel blockers (CCBs) are commonly prescribed for cardiovascular disease. Beyond hemodynamic effects, experimental studies suggest that CCBs may modulate tumor biology through interference...

Epithelial–mesenchymal transition in carcinoma: navigating phenotypic states to target resistance and metastasis

Epithelial–mesenchymal transition (EMT), historically described as a binary morphological change from an epithelium to a mesenchymal state, no longer adequately accounts for carcinoma cell phenotypes observed in patients. Single-cell sequencing, spatial-omics, and lineage tracing...

P1.057. Early Recurrence After Neoadjuvant Therapy and Esophagectomy for Locally Advanced ESCC

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Despite improved interventions with radical esophagectomy accompanied by perioperative systematic therapy, recurrence remains frequent in locally advanced esophageal squamous cell carcinoma (ESCC). A...

P1.058. Angiotensin System Inhibitors and Outcomes After Neoadjuvant Therapy for Locally Advanced ESCC

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Renin angiotensin system signaling has been implicated in tumor growth, angiogenesis, immune modulation, and responses to cytotoxic and radiation-based therapies, yet clinical effects appear heteroge...

P1.073. The Evaluative Value of Quality of Life in Neoadjuvant Treatment for Esophageal Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background While neoadjuvant therapy contribute to tumor downstaging and improves resectability rates, effective tools for predicting treatment response remain limited. This study investigated quality of life b...

Single-cell transcriptomics and functional validation reveal a TUBB4B-associated malignant epithelial state in nasopharyngeal carcinoma

Intratumoral heterogeneity of malignant epithelial cells limits prognostic stratification and therapeutic development in NPC, yet transcriptionally distinct malignant epithelial states and their associated molecular programs remain poorly characterized. We aimed to identify clini...

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Ventilator-induced lung injury (VILI), an iatrogenic complication of mechanical ventilation, remains poorly understood due to the absence of physiologically relevant in vitro models, impeding targeted therapy development. Here, we engineer a bioinspired acinus-on-a-chip model rec...

Blocking AGEs reduces airway epithelial viral susceptibility in diabetes-exacerbated COPD

Abstract Although diabetic complications are well-established in multiple organs, their impact on the respiratory system remains unclear. Clinical evidence indicates accelerated chronic obstructive pulmonary disease (COPD) progression in individuals with diabetes, yet the underly...

Palliative care knowledge and attitudes toward end-of-life care among clinical nurses across healthcare settings in Guangzhou, China: a cross-sectional study

Despite growing global recognition of palliative care’s importance, access to adequately trained professionals and high-quality services remains highly unequal across countries. Nurses’ knowledge and attitudes are critical determinants of end-of-life care quality, yet evidence fr...

Association between calling and work engagement, and the mediating role of psychological capital and organizational commitment: a structural equation modeling study in China

Abstract Purpose This research aimed to examine the association between calling and work engagement, as well as the mediating roles of psychological capital and organizational commitment. The findings may inform the development of targeted interventions to enhance work engagement...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Procalcitonin for diagnosing infected pancreatic necrosis: a systematic review and meta-analysis

Abstract Background Infected pancreatic necrosis (IPN) ranks among the most severe local complications of acute pancreatitis (AP) and plays a central role in driving AP-related death. Procalcitonin (PCT), a serum biomarker that responds preferentially to bacterial infection, has...

Ambient nitrogen dioxide and composition-specific risk of urolithiasis: a multicenter time-stratified case-crossover study

Background: Emerging evidence suggests that ambient air pollution and meteorological variation may trigger urolithiasis, but stone-composition–specific and lagged associations are poorly characterized.Methods: We conducted a multicenter, time-stratified case-crossover study in Gu...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...